[Term]
id: PR:000048286
name: lysosomal alpha-mannosidase, signal peptide removed form (human)
def: "A lysosomal alpha-mannosidase (human) that has had the signal peptide removed. UniProtKB:O00754, 50-1011." [PRO:DNx, Reactome:R-HSA-8853696]
comment: Category=organism-modification.
synonym: "PRO_0000012069" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAN2B1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00754, 50-1011" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6799216 "PR:000048286 located_in GO:0035578"
xref: Reactome:R-HSA-6806175 "PR:000048286 located_in GO:0005576"
xref: Reactome:R-HSA-8853696 "PR:000048286 located_in GO:0043202"
intersection_of: PR:O00754 ! lysosomal alpha-mannosidase (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00754
name: lysosomal alpha-mannosidase (human)
def: "A lysosomal alpha-mannosidase that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00754]
comment: Category=organism-gene.
synonym: "MANB" RELATED Gene-based [UniProtKB:O00754]
synonym: "LAMAN" RELATED Gene-based [UniProtKB:O00754]
synonym: "MAN2B1" RELATED Gene-based [UniProtKB:O00754]
synonym: "hMAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "mannosidase alpha-B (human)" EXACT [UniProtKB:O00754]
synonym: "lysosomal acid alpha-mannosidase (human)" EXACT [UniProtKB:O00754]
synonym: "mannosidase alpha class 2B member 1 (human)" EXACT [UniProtKB:O00754]
xref: UniProtKB:O00754
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase
relationship: has_gene_template HGNC:6826 ! MAN2B1 (human)

[Term]
id: PR:O00754-2
name: lysosomal alpha-mannosidase isoform h2 (human)
def: "A lysosomal alpha-mannosidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00754-2." [PRO:DNx, UniProtKB:O00754]
comment: Category=organism-sequence.
synonym: "hMAN2B1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00754-2
is_a: PR:O00754 ! lysosomal alpha-mannosidase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00754-1
name: lysosomal alpha-mannosidase isoform h1 (human)
def: "A lysosomal alpha-mannosidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00754-1." [PRO:DNx, UniProtKB:O00754]
comment: Category=organism-sequence.
synonym: "hMAN2B1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00754-1
is_a: PR:O00754 ! lysosomal alpha-mannosidase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000010107
name: lysosomal alpha-mannosidase
def: "A protein that is a translation product of the human MAN2B1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MANB" RELATED Gene-based []
synonym: "LAMAN" RELATED Gene-based []
synonym: "Man2b" RELATED Gene-based []
synonym: "laman" EXACT []
synonym: "MAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "mannosidase alpha-B" EXACT []
synonym: "lysosomal acid alpha-mannosidase" EXACT []
synonym: "mannosidase alpha class 2B member 1" EXACT []
is_a: PR:000000001 ! protein