[Term]
id: PR:O00754
name: lysosomal alpha-mannosidase (human)
def: "A lysosomal alpha-mannosidase that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00754]
comment: Category=organism-gene.
synonym: "MANB" RELATED Gene-based [UniProtKB:O00754]
synonym: "LAMAN" RELATED Gene-based [UniProtKB:O00754]
synonym: "MAN2B1" RELATED Gene-based [UniProtKB:O00754]
synonym: "hMAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "mannosidase alpha-B (human)" EXACT [UniProtKB:O00754]
synonym: "lysosomal acid alpha-mannosidase (human)" EXACT [UniProtKB:O00754]
synonym: "mannosidase alpha class 2B member 1 (human)" EXACT [UniProtKB:O00754]
xref: UniProtKB:O00754
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase
relationship: has_gene_template HGNC:6826 ! MAN2B1 (human)

[Term]
id: PR:000050693
name: lysosomal alpha-mannosidase N-glycosylated 1 (human)
def: "A lysosomal alpha-mannosidase (human) that has been N-glycosylated at the residue equivalent to Asn-497 of the amino acid sequence represented by UniProtKB:O00754-1, in which the glycan composition is represented by GlyTouCan:G28681TP. Example: UniProtKB:O00754-1, Asn-497, MOD:00160~GNO:G28681TP." [GlyGen:O00754-1, PMID:23345538, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hMAN2B1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00754-1, Asn-497, MOD:00160~GNO:G28681TP" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O00754 ! lysosomal alpha-mannosidase (human)
relationship: has_part GNO:G28681TP ! G28681TP
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000010107
name: lysosomal alpha-mannosidase
def: "A protein that is a translation product of the human MAN2B1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MANB" RELATED Gene-based []
synonym: "LAMAN" RELATED Gene-based []
synonym: "Man2b" RELATED Gene-based []
synonym: "laman" EXACT []
synonym: "MAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "mannosidase alpha-B" EXACT []
synonym: "lysosomal acid alpha-mannosidase" EXACT []
synonym: "mannosidase alpha class 2B member 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O09159
name: lysosomal alpha-mannosidase (mouse)
def: "A lysosomal alpha-mannosidase that is encoded in the genome of mouse." [OMA:O09159, PRO:DNx]
comment: Category=organism-gene.
synonym: "Manb" RELATED Gene-based [UniProtKB:O09159]
synonym: "Laman" RELATED Gene-based [UniProtKB:O09159]
synonym: "Man2b" RELATED Gene-based [UniProtKB:O09159]
synonym: "Man2b1" RELATED Gene-based [UniProtKB:O09159]
synonym: "mMAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "laman (mouse)" EXACT [UniProtKB:O09159]
synonym: "mannosidase alpha-B (mouse)" EXACT [UniProtKB:O09159]
synonym: "lysosomal acid alpha-mannosidase (mouse)" EXACT [UniProtKB:O09159]
synonym: "mannosidase alpha class 2B member 1 (mouse)" EXACT [UniProtKB:O09159]
xref: UniProtKB:O09159
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase
relationship: has_gene_template MGI:107286 ! Man2b1 (mouse)

[Term]
id: PR:000048286
name: lysosomal alpha-mannosidase, signal peptide removed form (human)
def: "A lysosomal alpha-mannosidase (human) that has had the signal peptide removed. UniProtKB:O00754, 50-1011." [PRO:DNx, Reactome:R-HSA-8853696]
comment: Category=organism-modification.
synonym: "PRO_0000012069" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAN2B1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00754, 50-1011" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6799216 "PR:000048286 located_in GO:0035578"
xref: Reactome:R-HSA-6806175 "PR:000048286 located_in GO:0005576"
xref: Reactome:R-HSA-8853696 "PR:000048286 located_in GO:0043202"
intersection_of: PR:O00754 ! lysosomal alpha-mannosidase (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00754-1
name: lysosomal alpha-mannosidase isoform h1 (human)
def: "A lysosomal alpha-mannosidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00754-1." [PRO:DNx, UniProtKB:O00754]
comment: Category=organism-sequence.
synonym: "hMAN2B1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00754-1
is_a: PR:O00754 ! lysosomal alpha-mannosidase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P34098
name: lysosomal alpha-mannosidase (Dictyostelium discoideum)
def: "A lysosomal alpha-mannosidase that is encoded in the genome of Dictyostelium discoideum." [OMA:P34098, PANTHER:PTHR11607:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "manA" RELATED Gene-based [UniProtKB:P34098]
synonym: "DDB_G0292206" RELATED Gene-based [UniProtKB:P34098]
synonym: "Dicty-MAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "laman (Dictyostelium discoideum)" EXACT [UniProtKB:P34098]
synonym: "alpha-mannosidase A (Dictyostelium discoideum)" EXACT [UniProtKB:P34098]
synonym: "alpha-D-mannoside mannohydrolase (Dictyostelium discoideum)" EXACT [UniProtKB:P34098]
xref: UniProtKB:P34098
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase
relationship: has_gene_template dictyBase:DDB_G0292206 ! manA (Dictyostelium discoideum)

[Term]
id: PR:000020525
name: lysosomal alpha-mannosidase proteolytic cleavage product
def: "A lysosomal alpha-mannosidase that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "MAN2B1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase

[Term]
id: PR:000020524
name: lysosomal alpha-mannosidase, signal peptide removed form
def: "A lysosomal alpha-mannosidase that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "MAN2B1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:O00754-2
name: lysosomal alpha-mannosidase isoform h2 (human)
def: "A lysosomal alpha-mannosidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00754-2." [PRO:DNx, UniProtKB:O00754]
comment: Category=organism-sequence.
synonym: "hMAN2B1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00754-2
is_a: PR:O00754 ! lysosomal alpha-mannosidase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q29451
name: lysosomal alpha-mannosidase (cow)
def: "A lysosomal alpha-mannosidase that is encoded in the genome of cow." [OMA:Q29451, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "MANB" RELATED Gene-based [UniProtKB:Q29451]
synonym: "MAN2B1" RELATED Gene-based [UniProtKB:Q29451]
synonym: "cow-MAN2B1" EXACT PRO-short-label [PRO:DNx]
synonym: "laman (cow)" EXACT [UniProtKB:Q29451]
synonym: "mannosidase alpha-B (cow)" EXACT [UniProtKB:Q29451]
synonym: "lysosomal acid alpha-mannosidase (cow)" EXACT [UniProtKB:Q29451]
synonym: "mannosidase alpha class 2B member 1 (cow)" EXACT [UniProtKB:Q29451]
xref: UniProtKB:Q29451
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000010107 ! lysosomal alpha-mannosidase
relationship: has_gene_template NCBIGene:282272 ! MAN2B1 (cow)