[Term]
id: PR:000008776
name: very-long-chain 3-oxoacyl-CoA reductase
def: "A protein that is a translation product of the human HSD17B12 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "KAR" EXACT []
synonym: "Kik1" RELATED Gene-based []
synonym: "KIK-I" EXACT []
synonym: "SDR12C1" RELATED Gene-based []
synonym: "HSD17B12" EXACT PRO-short-label [PRO:DNx]
synonym: "17-beta-HSD 12" EXACT []
synonym: "3-ketoacyl-CoA reductase" EXACT []
synonym: "estradiol 17-beta-dehydrogenase 12" EXACT []
synonym: "17-beta-hydroxysteroid dehydrogenase 12" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q53GQ0
name: very-long-chain 3-oxoacyl-CoA reductase (human)
def: "A very-long-chain 3-oxoacyl-CoA reductase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q53GQ0]
comment: Category=organism-gene.
synonym: "SDR12C1" RELATED Gene-based [UniProtKB:Q53GQ0]
synonym: "HSD17B12" RELATED Gene-based [UniProtKB:Q53GQ0]
synonym: "hHSD17B12" EXACT PRO-short-label [PRO:DNx]
synonym: "KAR (human)" EXACT [UniProtKB:Q53GQ0]
synonym: "17-beta-HSD 12 (human)" EXACT [UniProtKB:Q53GQ0]
synonym: "3-ketoacyl-CoA reductase (human)" EXACT [UniProtKB:Q53GQ0]
synonym: "estradiol 17-beta-dehydrogenase 12 (human)" EXACT [PRO:DNx]
synonym: "17-beta-hydroxysteroid dehydrogenase 12 (human)" EXACT [UniProtKB:Q53GQ0]
synonym: "short chain dehydrogenase/reductase family 12C member 1 (human)" EXACT [UniProtKB:Q53GQ0]
xref: Reactome:R-HSA-548766 "PR:Q53GQ0 located_in GO:0005789"
xref: UniProtKB:Q53GQ0
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008776 ! very-long-chain 3-oxoacyl-CoA reductase
relationship: has_gene_template HGNC:18646 ! HSD17B12 (human)

[Term]
id: PR:Q53GQ0-2
name: very-long-chain 3-oxoacyl-CoA reductase isoform h2 (human)
def: "A very-long-chain 3-oxoacyl-CoA reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q53GQ0-2." [PRO:DNx, UniProtKB:Q53GQ0]
comment: Category=organism-sequence.
synonym: "hHSD17B12/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q53GQ0-2
is_a: PR:Q53GQ0 ! very-long-chain 3-oxoacyl-CoA reductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q53GQ0-1
name: very-long-chain 3-oxoacyl-CoA reductase isoform 1 (human)
def: "A very-long-chain 3-oxoacyl-CoA reductase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hHSD17B12/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q53GQ0-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040886 ! very-long-chain 3-oxoacyl-CoA reductase isoform 1