[Term]
id: PR:000008730
name: 4-hydroxyphenylpyruvate dioxygenase
def: "A protein that is a translation product of the human HPD gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HPD" EXACT PRO-short-label [PRO:DNx]
synonym: "PPD" RELATED Gene-based []
synonym: "4HPPD" EXACT []
synonym: "HPPDase" EXACT []
synonym: "F protein" EXACT []
synonym: "F Alloantigen" EXACT []
synonym: "4-hydroxyphenylpyruvic acid oxidase" EXACT []
xref: IUPHARobj:2621
is_a: PR:000000001 ! protein

[Term]
id: PR:P32754
name: 4-hydroxyphenylpyruvate dioxygenase (human)
def: "A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P32754]
comment: Category=organism-gene.
synonym: "HPD" RELATED Gene-based [UniProtKB:P32754]
synonym: "PPD" RELATED Gene-based [UniProtKB:P32754]
synonym: "hHPD" EXACT PRO-short-label [PRO:DNx]
synonym: "4HPPD (human)" EXACT [UniProtKB:P32754]
synonym: "HPPDase (human)" EXACT [UniProtKB:P32754]
synonym: "4-hydroxyphenylpyruvic acid oxidase (human)" EXACT [UniProtKB:P32754]
xref: UniProtKB:P32754
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008730 ! 4-hydroxyphenylpyruvate dioxygenase
relationship: has_gene_template HGNC:5147 ! HPD (human)

[Term]
id: PR:000050394
name: 4-hydroxyphenylpyruvate dioxygenase isoform 1 phosphorylated 1 (human)
def: "A 4-hydroxyphenylpyruvate dioxygenase isoform 1 (human) that has been post-translationally modified to include phosphothreonine at position 382 of the amino acid sequence represented by UniProtKB:P32754-1. UniProtKB:P32754-1, Thr-382, MOD:00047." [PMID:31537781, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:31537781).
synonym: "hHPD/iso:1/Phos:1" EXACT PRO-short-label [PRO:KER]
synonym: "UniProtKB:P32754-1, Thr-382, MOD:00047" EXACT PRO-proteoform-std [PRO:KER]
is_a: PR:P32754-1 ! 4-hydroxyphenylpyruvate dioxygenase isoform 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047891
name: 4-hydroxyphenylpyruvate dioxygenase, initiator methionine removed form (human)
def: "A 4-hydroxyphenylpyruvate dioxygenase (human) that has had the initiator methionine removed. UniProtKB:P32754, 2-393." [PRO:DNx, Reactome:R-HSA-71159]
comment: Category=organism-modification.
synonym: "hHPD/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088388" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P32754, 2-393" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-71159 "PR:000047891 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P32754 ! 4-hydroxyphenylpyruvate dioxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P32754-1
name: 4-hydroxyphenylpyruvate dioxygenase isoform 1 (human)
def: "A 4-hydroxyphenylpyruvate dioxygenase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hHPD/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32754-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039302 ! 4-hydroxyphenylpyruvate dioxygenase isoform 1

[Term]
id: PR:P32754-2
name: 4-hydroxyphenylpyruvate dioxygenase isoform h2 (human)
def: "A 4-hydroxyphenylpyruvate dioxygenase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32754-2." [PRO:DNx, UniProtKB:P32754]
comment: Category=organism-sequence.
synonym: "hHPD/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P32754-2
is_a: PR:P32754 ! 4-hydroxyphenylpyruvate dioxygenase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens