[Term]
id: PR:000044916
name: histone H2A type 1-B/E, initiator methionine removed biotinylated 3 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-10, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK9bio" BROAD [HIstome_ptm_Hs:H2AK9bio]
synonym: "hHIST1H2A[B/E]/InitMet-/Btn:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-10, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-10, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044917
name: histone H2A type 1-B/E, initiator methionine removed dimethylated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Arg-4, MOD:00783." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:18079182, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AR3me2" BROAD [HIstome_ptm_Hs:H2AR3me2]
synonym: "hHIST1H2A[B/E]/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Arg-4, MOD:00783" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Arg-4, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044914
name: histone H2A type 1-B/E, initiator methionine removed biotinylated 2 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-14, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK13bio" BROAD [HIstome_ptm_Hs:H2AK13bio]
synonym: "hHIST1H2A[B/E]/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-14, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-14, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044915
name: histone H2A type 1-B/E, initiator methionine removed acetylated 2 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:12937907, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK9ac" BROAD [HIstome_ptm_Hs:H2AK9ac]
synonym: "hHIST1H2A[B/E]/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-10, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-10, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044912
name: histone H2A type 1-B/E, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been ubiquitinated at the position equivalent to Lys-120 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-120, MOD:01148." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:15386022, PMID:18400894, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK119ub" BROAD [HIstome_ptm_Hs:H2AK119ub]
synonym: "hHIST1H2A[B/E]/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-120, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-120, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782483 "PR:000044912 located_in GO:0005654"
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044913
name: histone H2A type 1-B/E, initiator methionine removed phosphorylated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-2 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Ser-2, MOD:00046." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:15010469, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AS1ph" BROAD [HIstome_ptm_Hs:H2AS1ph]
synonym: "hHIST1H2A[B/E]/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Ser-2, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:13774
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044910
name: histone H2A type 1-B/E, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-14, MOD:01399." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK13ar" BROAD [HIstome_ptm_Hs:H2AK13ar]
synonym: "hHIST1H2A[B/E]/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-14, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-14, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044911
name: histone H2A type 1-B/E, initiator methionine removed acetylated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:17709392, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK5ac" BROAD [HIstome_ptm_Hs:H2AK5ac]
synonym: "hHIST1H2A[B/E]/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568598 "PR:000044911 located_in GO:0005654"
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044909
name: histone H2A type 1-B/E, initiator methionine removed citrullinated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Arg-4, MOD:00219." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:15823041, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AR3ci" BROAD [HIstome_ptm_Hs:H2AR3ci]
synonym: "hHIST1H2A[B/E]/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Arg-4, MOD:00219" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Arg-4, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:15984
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044908
name: histone H2A type 1-B/E, initiator methionine removed biotinylated 1 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-130 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-130, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK129bio" BROAD [HIstome_ptm_Hs:H2AK129bio]
synonym: "hHIST1H2A[B/E]/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-130, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-130, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044920
name: histone H2A type 1-B/E, initiator methionine removed phosphorylated 2 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Thr-121 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Thr-121, MOD:00047." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:19965387, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AT120ph" BROAD [HIstome_ptm_Hs:H2AT120ph]
synonym: "hHIST1H2A[B/E]/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Thr-121, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Thr-121, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044918
name: histone H2A type 1-B/E, initiator methionine removed biotinylated 4 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-126 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-126, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK125bio" BROAD [HIstome_ptm_Hs:H2AK125bio]
synonym: "hHIST1H2A[B/E]/InitMet-/Btn:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-126, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-126, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044919
name: histone H2A type 1-B/E, initiator methionine removed biotinylated 5 (human)
def: "A histone H2A type 1-B/E (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-128 of the amino acid sequence represented by UniProtKB:P04908. UniProtKB:P04908, 2-130, Lys-128, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1-B/E, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1-B/E:H2AK127bio" BROAD [HIstome_ptm_Hs:H2AK127bio]
synonym: "hHIST1H2A[B/E]/InitMet-/Btn:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055237, Lys-128, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04908, 2-130, Lys-128, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P04908 ! histone H2A type 1-B/E (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P04908
name: histone H2A type 1-B/E (human)
def: "A histone H2A type 1-B/E that is encoded in the genome of human." [PRO:DAN, UniProtKB:P04908]
comment: Category=organism-gene. Note: The HIST1H2AB and HIST1H2AE genes encode identical proteins.
synonym: "H2AC4" RELATED Gene-based [UniProtKB:P04908]
synonym: "H2AC8" RELATED Gene-based [UniProtKB:P04908]
synonym: "H2AFA" RELATED Gene-based [UniProtKB:P04908]
synonym: "H2AFM" RELATED Gene-based [UniProtKB:P04908]
synonym: "HIST1H2AB" RELATED Gene-based [UniProtKB:P04908]
synonym: "HIST1H2AE" RELATED Gene-based [UniProtKB:P04908]
synonym: "hHIST1H2A[B/E]" EXACT PRO-short-label [PRO:DNx]
synonym: "histone H2A.2 (human)" BROAD [UniProtKB:P04908]
synonym: "histone H2A/a (human)" EXACT [UniProtKB:P04908]
synonym: "histone H2A/m (human)" EXACT [UniProtKB:P04908]
xref: UniProtKB:P04908
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008583 ! histone H2A type 1-B/E
relationship: has_gene_template HGNC:4724 ! HIST1H2AE (human)
relationship: has_gene_template HGNC:4734 ! HIST1H2AB (human)

[Term]
id: PR:000008583
name: histone H2A type 1-B/E
def: "A histone H2A that is a translation product of the human HIST1H2AB or HIST1H2AE genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN]
comment: Category=gene. Note: The human HIST1H2AB and HIST1H2AE genes encode identical proteins.
synonym: "H2AC4" RELATED Gene-based []
synonym: "H2AC8" RELATED Gene-based []
synonym: "H2AFA" RELATED Gene-based []
synonym: "H2AFM" RELATED Gene-based []
synonym: "HIST1H2AB" RELATED Gene-based []
synonym: "HIST1H2AE" RELATED Gene-based []
synonym: "HIST1H2A[B/E]" EXACT PRO-short-label [PRO:DNx]
synonym: "histone H2A.2" BROAD [PRO:DNx]
synonym: "histone H2A/a" EXACT []
synonym: "histone H2A/m" EXACT []
is_a: PR:000027547 ! histone H2A