[Term]
id: PR:000050026
name: hemoglobin subunit beta
def: "A beta-globin that is a translation product of the human HBB gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "HBB" EXACT PRO-short-label [PRO:DNx]
synonym: "hemoglobin beta chain" RELATED []
is_a: PR:000008457 ! beta-globin

[Term]
id: PR:P04443
name: hemoglobin subunit beta-H0 (mouse)
def: "A hemoglobin subunit beta-H0 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P04443]
comment: Category=organism-gene.
synonym: "Hbb-bh0" RELATED Gene-based [UniProtKB:P04443]
synonym: "mHbb-bh0" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-H0-globin (mouse)" EXACT [UniProtKB:P04443]
synonym: "hemoglobin beta-H0 chain (mouse)" EXACT [UniProtKB:P04443]
xref: UniProtKB:P04443
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008859 ! hemoglobin subunit beta-H0
relationship: has_gene_template MGI:96023 ! Hbb-bh0 (mouse)

[Term]
id: PR:000020114
name: hemoglobin subunit beta, initiator methionine removed form
def: "A hemoglobin subunit beta that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "HBB/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:000050026 ! hemoglobin subunit beta

[Term]
id: PR:000020115
name: hemoglobin subunit beta proteolytic cleavage product
def: "A hemoglobin subunit beta that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "HBB/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000050026 ! hemoglobin subunit beta

[Term]
id: PR:000008857
name: hemoglobin subunit beta-1
def: "A beta-globin that is a translation product of the mouse Hbb-b1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=CL.
synonym: "Hbb-b1" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-1-globin" EXACT []
synonym: "hemoglobin beta-1 chain" EXACT []
synonym: "hemoglobin beta-major chain" EXACT []
is_a: PR:000008457 ! beta-globin

[Term]
id: PR:000047681
name: hemoglobin subunit beta, initiator methionine removed form (human)
def: "A hemoglobin subunit beta (human) that has had the initiator methionine removed. UniProtKB:P68871, 2-147." [PRO:DNx, Reactome:R-HSA-1008196, Reactome:R-HSA-2168872, Reactome:R-HSA-2230936]
comment: Category=organism-modification.
synonym: "hHBB/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000052976" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P68871, 2-147" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1008196 "PR:000047681 located_in GO:0005829"
xref: Reactome:R-HSA-2168872 "PR:000047681 located_in GO:0005576"
xref: Reactome:R-HSA-2230936 "PR:000047681 located_in GO:0071682"
xref: Reactome:R-HSA-6800191 "PR:000047681 located_in GO:1904724"
xref: Reactome:R-HSA-6801015 "PR:000047681 located_in GO:1904813"
xref: Reactome:R-HSA-9625193 "PR:000047681 located_in GO:0043202"
xref: Reactome:R-HSA-9631108 "PR:000047681 located_in GO:0031906"
xref: TDR:5507
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P68871 ! hemoglobin subunit beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04444
name: hemoglobin subunit beta-H1 (mouse)
def: "A hemoglobin subunit beta-H1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P04444]
comment: Category=organism-gene.
synonym: "Hbb-bh1" RELATED Gene-based [UniProtKB:P04444]
synonym: "mHbb-bh1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Z (mouse)" EXACT [UniProtKB:P04444]
synonym: "beta-H1-globin (mouse)" EXACT [UniProtKB:P04444]
synonym: "hemoglobin beta-H1 chain (mouse)" EXACT [UniProtKB:P04444]
xref: UniProtKB:P04444
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008860 ! hemoglobin subunit beta-H1
relationship: has_gene_template MGI:96024 ! Hbb-bh1 (mouse)

[Term]
id: PR:P02091
name: hemoglobin subunit beta-1 (rat)
def: "A beta-globin that is a translation product of the Hbb gene in rat." [PRO:DAN, UniProtKB:P02091]
comment: Category=organism-gene.
synonym: "Hbb" RELATED Gene-based [UniProtKB:P02091]
synonym: "rHbb-b1" EXACT PRO-short-label [PRO:DAN]
synonym: "beta-1-globin (rat)" EXACT [UniProtKB:P02091]
synonym: "hemoglobin beta-1 chain (rat)" EXACT [UniProtKB:P02091]
synonym: "hemoglobin beta chain, major-form (rat)" EXACT [UniProtKB:P02091]
xref: UniProtKB:P02091
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008457 ! beta-globin
intersection_of: has_gene_template RGD:2783 ! Hbb (rat)

[Term]
id: PR:P11517
name: hemoglobin subunit beta-2 (rat)
def: "A hemoglobin subunit beta-2 that is encoded in the genome of rat." [PRO:DAN, UniProtKB:P11517]
comment: Category=organism-gene. Note: The LOC689064 and rCG_39884 genes encode identical proteins.
synonym: "Hbb-bs" RELATED Gene-based [UniProtKB:P11517]
synonym: "rHbb-b2" EXACT PRO-short-label [PRO:DAN]
synonym: "LOC100134871" RELATED Gene-based [UniProtKB:P11517]
synonym: "LOC103694857" RELATED Gene-based [UniProtKB:P11517]
synonym: "beta-2-globin (rat)" EXACT [UniProtKB:P11517]
synonym: "hemoglobin beta-2 chain (rat)" EXACT [UniProtKB:P11517]
synonym: "hemoglobin beta chain, minor-form (rat)" EXACT [UniProtKB:P11517]
xref: UniProtKB:P11517
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008858 ! hemoglobin subunit beta-2
relationship: has_gene_template RGD:1597422 ! LOC689064 (rat)
relationship: has_gene_template RGD:2290038 ! rCG_39884 (rat)

[Term]
id: PR:P02112
name: hemoglobin subunit beta (chicken)
def: "A hemoglobin subunit beta that is a translation product of the HBB gene in chicken." [PRO:DAN, UniProtKB:P02112]
comment: Category=organism-gene.
synonym: "HBB" RELATED Gene-based [UniProtKB:P02112]
synonym: "chick-HBB" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-globin (chicken)" EXACT [UniProtKB:P02112]
synonym: "hemoglobin beta chain (chicken)" EXACT [UniProtKB:P02112]
xref: UniProtKB:P02112
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000050026 ! hemoglobin subunit beta
relationship: has_gene_template NCBIGene:396485 ! HBB (chicken)

[Term]
id: PR:000008859
name: hemoglobin subunit beta-H0
def: "A beta-globin that is a translation product of the mouse Hbb-bh0 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Hbb-bh0" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-H0-globin" EXACT []
synonym: "hemoglobin beta-H0 chain" EXACT []
is_a: PR:000008457 ! beta-globin

[Term]
id: PR:000008858
name: hemoglobin subunit beta-2
def: "A beta-globin that is a translation product of the mouse Hbb-b2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Hbb-b2" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-2-globin" EXACT []
synonym: "hemoglobin beta-2 chain" EXACT []
synonym: "hemoglobin beta-minor chain" EXACT []
is_a: PR:000008457 ! beta-globin

[Term]
id: PR:000008457
name: beta-globin
def: "A hemoglobin subunit that is a translation product of the human HBB gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:DAN]
comment: Category=gene.
synonym: "b-globin" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000050467 ! hemoglobin subunit

[Term]
id: PR:000056675
name: hemoglobin subunit beta O-glycosylated 1 (human)
def: "A hemoglobin subunit beta (human) that has been O-glycosylated at the residue equivalent to Ser-45 of the amino acid sequence represented by UniProtKB:P68871-1, in which the glycan composition is represented by GlyTouCan:G27391WQ. Example: UniProtKB:P68871-1, Ser-45, MOD:00002~GNO:G27391WQ." [GlyGen:P68871-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hHBB/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P68871-1, Ser-45, MOD:00002~GNO:G27391WQ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P68871 ! hemoglobin subunit beta (human)
relationship: has_part GNO:G27391WQ ! G27391WQ
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050468
name: hemoglobin subunit beta N-1-deoxyfructosylated 1
def: "A hemoglobin subunit beta, initiator methionine removed form that has been N-1-deoxyfructosylated at the position equivalent to Val-2 of the sequence represented by UniProtKB:P68871-1 or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=modification.
synonym: "HBB/InitMet-/dFruc:1" EXACT PRO-short-label [PRO:DAN]
synonym: "beta-N-1-deoxy fructosyl hemoglobin subunit" BROAD [PRO:DAN]
is_a: PR:000020114 ! hemoglobin subunit beta, initiator methionine removed form

[Term]
id: PR:P68871
name: hemoglobin subunit beta (human)
def: "A hemoglobin subunit beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P68871]
comment: Category=organism-gene.
synonym: "HBB" RELATED Gene-based [UniProtKB:P68871]
synonym: "hHBB" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-globin (human)" EXACT [UniProtKB:P68871]
synonym: "hemoglobin beta chain (human)" EXACT [UniProtKB:P68871]
xref: UniProtKB:P68871
intersection_of: has_gene_template HGNC:4827 ! HBB (human)
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000050026 ! hemoglobin subunit beta

[Term]
id: PR:000008860
name: hemoglobin subunit beta-H1
def: "A beta-globin that is a translation product of the mouse Hbb-bh1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Hbb-bh1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Z" EXACT []
synonym: "beta-H1-globin" EXACT []
synonym: "hemoglobin beta-H1 chain" EXACT []
is_a: PR:000008457 ! beta-globin

[Term]
id: PR:P02089
name: hemoglobin subunit beta-2 (mouse)
def: "A hemoglobin subunit beta-2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P02089]
comment: Category=organism-gene.
synonym: "Hbb-b2" RELATED Gene-based [UniProtKB:P02089]
synonym: "mHbb-b2" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-2-globin (mouse)" EXACT [UniProtKB:P02089]
synonym: "hemoglobin beta-2 chain (mouse)" EXACT [UniProtKB:P02089]
synonym: "hemoglobin beta-minor chain (mouse)" EXACT [UniProtKB:P02089]
xref: UniProtKB:P02089
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008858 ! hemoglobin subunit beta-2
relationship: has_gene_template MGI:96022 ! Hbb-b2 (mouse)

[Term]
id: PR:P02088
name: hemoglobin subunit beta-1 (mouse)
def: "A hemoglobin subunit beta-1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P02088]
comment: Category=organism-gene.
synonym: "Hbb-b1" RELATED Gene-based [UniProtKB:P02088]
synonym: "mHbb-b1" EXACT PRO-short-label [PRO:DNx]
synonym: "beta-1-globin (mouse)" EXACT [UniProtKB:P02088]
synonym: "hemoglobin beta-1 chain (mouse)" EXACT [UniProtKB:P02088]
synonym: "hemoglobin beta-major chain (mouse)" EXACT [UniProtKB:P02088]
xref: UniProtKB:P02088
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008857 ! hemoglobin subunit beta-1
relationship: has_gene_template MGI:96021 ! Hbb-b1 (mouse)

[Term]
id: PR:000020224
name: hemoglobin subunit beta-H0, initiator methionine removed form
def: "A hemoglobin subunit beta-H0 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "Hbb-bh0/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008859 ! hemoglobin subunit beta-H0
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000020225
name: hemoglobin subunit beta-H1, initiator methionine removed form
def: "A hemoglobin subunit beta-H1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "Hbb-bh1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008860 ! hemoglobin subunit beta-H1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000020222
name: hemoglobin subunit beta-1, initiator methionine removed form
def: "A hemoglobin subunit beta-1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "Hbb-b1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008857 ! hemoglobin subunit beta-1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000020223
name: hemoglobin subunit beta-2, initiator methionine removed form
def: "A hemoglobin subunit beta-2 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "Hbb-b2/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008858 ! hemoglobin subunit beta-2
intersection_of: lacks_part PR:000021937 ! initiator methionine