[Term]
id: PR:000045300
name: histone H3.3, initiator methionine removed ADP-ribosylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-38 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-38, MOD:01399." [HIstome_var_Hs:Histone_H3.3, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K37ar" BROAD [HIstome_ptm_Hs:H3K37ar]
synonym: "hH3.3/InitMet-/ADPrib:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-38, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045301
name: histone H3.3, initiator methionine removed trimethylated 4 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-37 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-37, MOD:00083." [HIstome_var_Hs:Histone_H3.3, PMID:19483677, PMID:20018718, PMID:21239496, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K36me3" BROAD [HIstome_ptm_Hs:H3K36me3]
synonym: "hH3.3/InitMet-/Me3:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-37, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045302
name: histone H3.3, initiator methionine removed dimethylated 5 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-28 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-28, MOD:00084." [HIstome_var_Hs:Histone_H3.3, PMID:18172012, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K27me2" BROAD [HIstome_ptm_Hs:H3K27me2]
synonym: "hH3.3/InitMet-/Me2:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-28, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:13022
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045303
name: histone H3.3, initiator methionine removed acetylated 7 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-57 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-57, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:19270680, PMID:19625767, PMID:20587414, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K56ac" BROAD [HIstome_ptm_Hs:H3K56ac]
synonym: "hH3.3/InitMet-/Ac:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-57, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045304
name: histone H3.3, initiator methionine removed citrullinated 4 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-3 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-3, MOD:00219." [HIstome_var_Hs:Histone_H3.3, PMID:15339660, PMID:17079667, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R2ci" BROAD [HIstome_ptm_Hs:H3R2ci]
synonym: "hH3.3/InitMet-/Cit:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-3, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045305
name: histone H3.3, initiator methionine removed phosphorylated 7 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Ser-29, MOD:00046." [HIstome_var_Hs:Histone_H3.3, PMID:11856369, PMID:21282660, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3S28ph" BROAD [HIstome_ptm_Hs:H3S28ph]
synonym: "hH3.3/InitMet-/Phos:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Ser-29, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:13207
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045269
name: histone H3.3, initiator methionine removed phosphorylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Thr-12 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Thr-12, MOD:00047." [HIstome_var_Hs:Histone_H3.3, PMID:12560483, PMID:18066052, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3T11ph" BROAD [HIstome_ptm_Hs:H3T11ph]
synonym: "hH3.3/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Thr-12, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5625878 "PR:000045269 located_in GO:0005654"
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000008425
name: histone H3.3
def: "A histone H3 that is a translation product of the human H3F3A or H3F3B genes, 1:1 orthologs thereof, a semi-ortholog thereof, or pro-orthologs thereof." [PRO:DNx]
comment: Category=family. Note: The number of genes encoding histone H3.3 varies in different organisms. Humans, for example, have two, while zebrafish have five.
synonym: "H3.3" EXACT PRO-short-label [PRO:DNx]
synonym: "H3F3" RELATED Gene-based []
synonym: "H3-3A" RELATED Gene-based []
synonym: "H3-3B" RELATED Gene-based []
synonym: "H3.3A" RELATED Gene-based []
synonym: "H3.3B" RELATED Gene-based []
synonym: "H3F3A" RELATED Gene-based []
synonym: "H3F3B" RELATED Gene-based [PRO:DNx]
synonym: "PP781" RELATED Gene-based []
is_a: PR:000027594 ! histone H3

[Term]
id: PR:000045308
name: histone H3.3, initiator methionine removed dimethylated 6 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-10, MOD:00084." [HIstome_var_Hs:Histone_H3.3, PMID:12232854, PMID:15153943, PMID:16861263, PMID:17314394, PMID:17901401, PMID:18552846, PMID:18776137, PMID:18850007, PMID:19349354, PMID:19349354, PMID:19739128, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K9me2" BROAD [HIstome_ptm_Hs:H3K9me2]
synonym: "hH3.3/InitMet-/Me2:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-10, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-427324 "PR:000045308 located_in GO:0005654"
xref: TDR:5808
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045309
name: histone H3.3, initiator methionine removed trimethylated 5 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-10, MOD:00083." [HIstome_var_Hs:Histone_H3.3, PMID:16061184, PMID:16861263, PMID:17403718, PMID:17478518, PMID:17968314, PMID:18579779, PMID:19593370, PMID:19739128, PMID:20404089, PMID:20498303, PMID:20843831, PMID:21062507, PMID:21430779, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K9me3" BROAD [HIstome_ptm_Hs:H3K9me3]
synonym: "hH3.3/InitMet-/Me3:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-10, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5625747 "PR:000045309 located_in GO:0005654"
xref: TDR:12361
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045306
name: histone H3.3, initiator methionine removed phosphorylated 8 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Tyr-42 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Tyr-42, MOD:00048." [HIstome_var_Hs:Histone_H3.3, PMID:19783980, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3Y41ph" BROAD [HIstome_ptm_Hs:H3Y41ph]
synonym: "hH3.3/InitMet-/Phos:8" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Tyr-42, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000036800
name: histone H3.3 acetylated and methylated 1 (human)
def: "A histone H3.3 that has been acetylated on the N-terminal Met and methylated and acetylated on several Lys residues in human. UniProtKB:P84243, Met-1, MOD:00058|Lys-10, MOD:00083|Lys-28, MOD:00084|Lys-80, MOD:00064." [TDR:7224]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hH3.3/AcMe:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P84243, Met-1, MOD:00058|Lys-10, MOD:00083|Lys-28, MOD:00084|Lys-80, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:7224
is_a: PR:000008425 ! histone H3.3
relationship: has_part MOD:00058 ! N-acetyl-L-methionine
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P84243
name: histone H3.3 (human)
def: "A histone H3.3 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene. Note: The H3F3A and H3F3B genes encode identical proteins.
synonym: "H3F3" RELATED Gene-based [UniProtKB:P84243]
synonym: "H3-3A" RELATED Gene-based [UniProtKB:P84243]
synonym: "H3-3B" RELATED Gene-based [UniProtKB:P84243]
synonym: "H3.3A" NARROW Gene-based [PRO:DAN, UniProtKB:P84243]
synonym: "H3.3B" NARROW Gene-based [PRO:DAN, UniProtKB:P84243]
synonym: "H3F3A" NARROW Gene-based [PRO:DAN, UniProtKB:P84243]
synonym: "H3F3B" NARROW Gene-based [PRO:DAN, UniProtKB:P84243]
synonym: "PP781" RELATED Gene-based [UniProtKB:P84243]
synonym: "hH3.3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P84243
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008425 ! histone H3.3
relationship: has_gene_template HGNC:4764 ! H3F3A (human)
relationship: has_gene_template HGNC:4765 ! H3F3B (human)

[Term]
id: PR:000045296
name: histone H3.3, initiator methionine removed trimethylated 3 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-80 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-80, MOD:00083." [HIstome_var_Hs:Histone_H3.3, PMID:12628190, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K79me3" BROAD [HIstome_ptm_Hs:H3K79me3]
synonym: "hH3.3/InitMet-/Me3:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-80, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045297
name: histone H3.3, initiator methionine removed acetylated 5 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:12419248, PMID:16544193, PMID:17403718, PMID:17478518, PMID:17906200, PMID:18337721, PMID:19135889, PMID:20816089, PMID:20972224, PMID:21453398, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K9ac" BROAD [HIstome_ptm_Hs:H3K9ac]
synonym: "hH3.3/InitMet-/Ac:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-10, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5250654 "PR:000045297 located_in GO:0005654"
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045294
name: histone H3.3, initiator methionine removed monomethylated 6 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-80 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-80, MOD:00085." [HIstome_var_Hs:Histone_H3.3, PMID:20699226, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K79me1" BROAD [HIstome_ptm_Hs:H3K79me1]
synonym: "hH3.3/InitMet-/Me1:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-80, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045295
name: histone H3.3, initiator methionine removed dimethylated 4 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-80 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-80, MOD:00084." [HIstome_var_Hs:Histone_H3.3, PMID:12123582, PMID:16307923, PMID:20699226, PMID:21741597, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K79me2" BROAD [HIstome_ptm_Hs:H3K79me2]
synonym: "hH3.3/InitMet-/Me2:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-80, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:12831
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045292
name: histone H3.3, initiator methionine removed acetylated 4 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-5 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-5, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K4ac" BROAD [HIstome_ptm_Hs:H3K4ac]
synonym: "hH3.3/InitMet-/Ac:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-5, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045293
name: histone H3.3, initiator methionine removed monomethylated 5 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-28 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-28, MOD:00085." [HIstome_var_Hs:Histone_H3.3, PMID:17030614, PMID:17512414, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K27me1" BROAD [HIstome_ptm_Hs:H3K27me1]
synonym: "hH3.3/InitMet-/Me1:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-28, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045290
name: histone H3.3, initiator methionine removed phosphorylated 6 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Thr-46 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Thr-46, MOD:00047." [HIstome_var_Hs:Histone_H3.3, PMID:19363025, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3T45ph" BROAD [HIstome_ptm_Hs:H3T45ph]
synonym: "hH3.3/InitMet-/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Thr-46, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045291
name: histone H3.3, initiator methionine removed trimethylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-28 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-28, MOD:00083." [HIstome_var_Hs:Histone_H3.3, PMID:12351676, PMID:12649488, PMID:16630819, PMID:17200670, PMID:17314394, PMID:18318442, PMID:18628788, PMID:18632628, PMID:18716661, PMID:19340297, PMID:19557159, PMID:19887624, PMID:21115743, PMID:21228036, PMID:21242977, PMID:21512140, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K27me3" BROAD [HIstome_ptm_Hs:H3K27me3]
synonym: "hH3.3/InitMet-/Me3:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-28, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-212282 "PR:000045291 located_in GO:0005654"
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045307
name: histone H3.3, initiator methionine removed monomethylated 7 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-10, MOD:00085." [HIstome_var_Hs:Histone_H3.3, PMID:16079795, PMID:16517599, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K9Me1" BROAD [HIstome_ptm_Hs:H3K9Me1]
synonym: "hH3.3/InitMet-/Me1:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-10, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-427369 "PR:000045307 located_in GO:0005654"
xref: TDR:14858
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045298
name: histone H3.3, initiator methionine removed acetylated 6 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-19 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-19, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:15988529, PMID:18552846, PMID:18953329, PMID:19349354, PMID:19349354, PMID:20841388, PMID:20978174, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K18ac" BROAD [HIstome_ptm_Hs:H3K18ac]
synonym: "hH3.3/InitMet-/Ac:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-19, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045299
name: histone H3.3, initiator methionine removed citrullinated 3 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-18 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-18, MOD:00219." [HIstome_var_Hs:Histone_H3.3, PMID:15339660, PMID:15345777, PMID:17079667, PMID:18209087, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R17ci" BROAD [HIstome_ptm_Hs:H3R17ci]
synonym: "hH3.3/InitMet-/Cit:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-18, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045313
name: histone H3.3, initiator methionine removed dimethylated 8 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-37 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-37, MOD:00084." [HIstome_var_Hs:Histone_H3.3, PMID:16861263, PMID:21187428, PMID:21239496, PMID:21310926, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K36me2" BROAD [HIstome_ptm_Hs:H3K36me2]
synonym: "hH3.3/InitMet-/Me2:8" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-37, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045312
name: histone H3.3, initiator methionine removed acetylated 8 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-15 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-15, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:12419248, PMID:16678094, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K14ac" BROAD [HIstome_ptm_Hs:H3K14ac]
synonym: "hH3.3/InitMet-/Ac:8" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-15, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045311
name: histone H3.3, initiator methionine removed monomethylated 8 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-18 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-18, MOD:00414." [HIstome_var_Hs:Histone_H3.3, PMID:15186775, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R17me1" BROAD [HIstome_ptm_Hs:H3R17me1]
synonym: "hH3.3/InitMet-/Me1:8" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-18, MOD:00414" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00414 ! monomethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045310
name: histone H3.3, initiator methionine removed dimethylated 7 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-18 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-18, MOD:00783." [HIstome_var_Hs:Histone_H3.3, PMID:16705743, PMID:17478518, PMID:18172323, PMID:18172323, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R17me2" BROAD [HIstome_ptm_Hs:H3R17me2]
synonym: "hH3.3/InitMet-/Me2:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-18, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045278
name: histone H3.3, initiator methionine removed acetylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-24 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-24, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:21164480, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K23ac" BROAD [HIstome_ptm_Hs:H3K23ac]
synonym: "hH3.3/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-24, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045279
name: histone H3.3, initiator methionine removed biotinylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-10, MOD:00126." [HIstome_var_Hs:Histone_H3.3, PMID:20688500, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K9bio" BROAD [HIstome_ptm_Hs:H3K9bio]
synonym: "hH3.3/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-10, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045274
name: histone H3.3, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-28 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-28, MOD:01399." [HIstome_var_Hs:Histone_H3.3, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K27ar" BROAD [HIstome_ptm_Hs:H3K27ar]
synonym: "hH3.3/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-28, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045275
name: histone H3.3, initiator methionine removed trimethylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been trimethylated at the position equivalent to Lys-5 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-5, MOD:00083." [HIstome_var_Hs:Histone_H3.3, PMID:12453418, PMID:16307923, PMID:16510874, PMID:16630819, PMID:16731913, PMID:17478518, PMID:18033247, PMID:18850007, PMID:20035052, PMID:21060806, PMID:21922516, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K4me3" BROAD [HIstome_ptm_Hs:H3K4me3]
synonym: "hH3.3/InitMet-/Me3:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-5, MOD:00083" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1214216 "PR:000045275 located_in GO:0005654"
xref: TDR:12549
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00083 ! N6,N6,N6-trimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045276
name: histone H3.3, initiator methionine removed dimethylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Lys-5 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-5, MOD:00084." [HIstome_var_Hs:Histone_H3.3, PMID:11498594, PMID:12232854, PMID:12453418, PMID:15123803, PMID:15988529, PMID:17906200, PMID:18632628, PMID:19349354, PMID:19349354, PMID:20841388, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K4me2" BROAD [HIstome_ptm_Hs:H3K4me2]
synonym: "hH3.3/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-5, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1214206 "PR:000045276 located_in GO:0005654"
xref: TDR:13320
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045277
name: histone H3.3, initiator methionine removed monomethylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-5 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-5, MOD:00085." [HIstome_var_Hs:Histone_H3.3, PMID:11498594, PMID:12453418, PMID:15123803, PMID:18809715, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K4me1" BROAD [HIstome_ptm_Hs:H3K4me1]
synonym: "hH3.3/InitMet-/Me1:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-5, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:2755
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045270
name: histone H3.3, initiator methionine removed citrullinated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-9 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-9, MOD:00219." [HIstome_var_Hs:Histone_H3.3, PMID:15339660, PMID:15345777, PMID:17079667, PMID:18209087, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R8ci" BROAD [HIstome_ptm_Hs:H3R8ci]
synonym: "hH3.3/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-9, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045271
name: histone H3.3, initiator methionine removed monomethylated 1 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-37 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-37, MOD:00085." [HIstome_var_Hs:Histone_H3.3, PMID:17544230, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K36me1" BROAD [HIstome_ptm_Hs:H3K36me1]
synonym: "hH3.3/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-37, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045272
name: histone H3.3, initiator methionine removed phosphorylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Thr-4 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Thr-4, MOD:00047." [HIstome_var_Hs:Histone_H3.3, PMID:15681610, PMID:19622635, PMID:20705812, PMID:20929775, PMID:20953165, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3T3ph" BROAD [HIstome_ptm_Hs:H3T3ph]
synonym: "hH3.3/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Thr-4, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:13799
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045273
name: histone H3.3, initiator methionine removed citrullinated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-27 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-27, MOD:00219." [HIstome_var_Hs:Histone_H3.3, PMID:15339660, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R26ci" BROAD [HIstome_ptm_Hs:H3R26ci]
synonym: "hH3.3/InitMet-/Cit:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-27, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P84243-1
name: histone H3.3 isoform 1 (human)
def: "A histone H3.3 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hH3.3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P84243-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040180 ! histone H3.3 isoform 1

[Term]
id: PR:000045281
name: histone H3.3, initiator methionine removed monomethylated 3 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-27 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-27, MOD:00414." [HIstome_var_Hs:Histone_H3.3, PMID:15186775, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R26me1" BROAD [HIstome_ptm_Hs:H3R26me1]
synonym: "hH3.3/InitMet-/Me1:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-27, MOD:00414" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00414 ! monomethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045280
name: histone H3.3, initiator methionine removed acetylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-37 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-37, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K36ac" BROAD [HIstome_ptm_Hs:H3K36ac]
synonym: "hH3.3/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-37, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045283
name: histone H3.3, initiator methionine removed phosphorylated 4 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-32 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Ser-32, MOD:00046." [HIstome_var_Hs:Histone_H3.3, PMID:15851689, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3S31ph" BROAD [HIstome_ptm_Hs:H3S31ph]
synonym: "hH3.3/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Ser-32, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045282
name: histone H3.3, initiator methionine removed phosphorylated 3 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Thr-7 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Thr-7, MOD:00047." [HIstome_var_Hs:Histone_H3.3, PMID:20228790, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3T6ph" BROAD [HIstome_ptm_Hs:H3T6ph]
synonym: "hH3.3/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Thr-7, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045285
name: histone H3.3, initiator methionine removed monomethylated 4 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Arg-3 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-3, MOD:00414." [HIstome_var_Hs:Histone_H3.3, PMID:15186775, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R2me1" BROAD [HIstome_ptm_Hs:H3R2me1]
synonym: "hH3.3/InitMet-/Me1:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-3, MOD:00414" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00414 ! monomethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045284
name: histone H3.3, initiator methionine removed phosphorylated 5 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-11 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Ser-11, MOD:00046." [HIstome_var_Hs:Histone_H3.3, PMID:10436156, PMID:12677454, PMID:14583461, PMID:16651411, PMID:18256527, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3S10ph" BROAD [HIstome_ptm_Hs:H3S10ph]
synonym: "hH3.3/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Ser-11, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:14482
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045287
name: histone H3.3, initiator methionine removed dimethylated 3 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-9 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-9, MOD:00783." [HIstome_var_Hs:Histone_H3.3, PMID:19998411, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R8me2" BROAD [HIstome_ptm_Hs:H3R8me2]
synonym: "hH3.3/InitMet-/Me2:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-9, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045286
name: histone H3.3, initiator methionine removed dimethylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-3 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Arg-3, MOD:00783." [HIstome_var_Hs:Histone_H3.3, PMID:17898714, PMID:18079182, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3R2me2" BROAD [HIstome_ptm_Hs:H3R2me2]
synonym: "hH3.3/InitMet-/Me2:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Arg-3, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045289
name: histone H3.3, initiator methionine removed acetylated 3 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-28 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-28, MOD:00064." [HIstome_var_Hs:Histone_H3.3, PMID:18552846, PMID:20385584, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K27ac" BROAD [HIstome_ptm_Hs:H3K27ac]
synonym: "hH3.3/InitMet-/Ac:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-28, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045288
name: histone H3.3, initiator methionine removed biotinylated 2 (human)
def: "A histone H3.3 (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-19 of the amino acid sequence represented by UniProtKB:P84243. UniProtKB:P84243, 2-136, Lys-19, MOD:00126." [HIstome_var_Hs:Histone_H3.3, PMID:20688500, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H3.3:H3K18bio" BROAD [HIstome_ptm_Hs:H3K18bio]
synonym: "hH3.3/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, 2-136, Lys-19, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P84243 ! histone H3.3 (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000036266
name: histone H3.3 acetylated 1 (human)
def: "A histone H3.3 that is N-terminal Met acetylated in human. UniProtKB:P84243, Met-1, MOD:00058." [TDR:2154]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hH3.3/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84243, Met-1, MOD:00058" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:2154
xref: TDR:16791
is_a: PR:000008425 ! histone H3.3
relationship: has_part MOD:00058 ! N-acetyl-L-methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens