[Term]
id: PR:000045018
name: histone H2AX, initiator methionine removed acetylated 1 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2A.x, PMID:17709392, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A.x:H2AK5ac" BROAD [HIstome_ptm_Hs:H2AK5ac]
synonym: "hH2AFX/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045019
name: histone H2AX, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and that has been ubiquitinated at the position equivalent to Lys-120 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-120, MOD:01148." [HIstome_var_Hs:Histone_H2A.x, PMID:15386022, PMID:18400894, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A.x:H2AK119ub" BROAD [HIstome_ptm_Hs:H2AK119ub]
synonym: "hH2AFX/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143, Lys-120, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045022
name: histone H2AX, initiator methionine removed phosphorylated 2 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Ser-140 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Ser-140, MOD:00046." [HIstome_var_Hs:Histone_H2A.x, PMID:10734083, PMID:10959836, PMID:10959836, PMID:12660252, PMID:18370922, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A.x:H2AS139ph" BROAD [HIstome_ptm_Hs:H2AS139ph]
synonym: "hH2AFX/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143, Ser-140, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-75170 "PR:000045022 located_in GO:0005654"
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045020
name: histone H2AX, initiator methionine removed phosphorylated 1 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated at the position equivalent to Tyr-143 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Tyr-143, MOD:00048." [HIstome_var_Hs:Histone_H2A.x, PMID:19092802, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A.x:H2AY142ph" BROAD [HIstome_ptm_Hs:H2AY142ph]
synonym: "hH2AFX/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143, Tyr-143, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5683942 "PR:000045020 located_in GO:0005654"
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P16104-1
name: histone H2AX isoform 1 (human)
def: "A histone H2AX isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hH2AFX/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16104-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038946 ! histone H2AX isoform 1

[Term]
id: PR:000008418
name: histone H2AX
def: "A histone H2A that is a translation product of the human H2AFX gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "H2AX" RELATED Gene-based []
synonym: "H2AFX" EXACT PRO-short-label [PRO:DNx]
synonym: "H2a.x" RELATED []
synonym: "H2a/x" EXACT []
synonym: "Hist5-2ax" RELATED []
synonym: "histone H2A.X" EXACT []
is_a: PR:000027547 ! histone H2A

[Term]
id: PR:000047669
name: histone H2AX, initiator methionine removed dimethylated 1 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and has been post-translationally modified to include symmetric dimethyl-L-arginine at position 4 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Arg-4, MOD:00076." [PRO:DNx, Reactome:R-HSA-5218317]
comment: Category=organism-modification.
synonym: "hH2AFX/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143, Arg-4, MOD:00076" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218317 "PR:000047669 located_in GO:0005654"
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:00076 ! symmetric dimethyl-L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045021
name: histone H2AX, initiator methionine removed acetylated 2 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H2A.x, PMID:12937907, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A.x:H2AK9ac" BROAD [HIstome_ptm_Hs:H2AK9ac]
synonym: "hH2AFX/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143, Lys-10, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047668
name: histone H2AX, initiator methionine removed form (human)
def: "A histone H2AX (human) that has had the initiator methionine removed. UniProtKB:P16104, 2-143." [PRO:DNx, Reactome:R-HSA-56151, Reactome:R-HSA-977583]
comment: Category=organism-modification.
synonym: "PRO_0000055242" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hH2AFX/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P16104, 2-143" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-56151 "PR:000047668 located_in GO:0005654"
xref: Reactome:R-HSA-977583 "PR:000047668 located_in GO:0005576"
xref: TDR:13278
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P16104 ! histone H2AX (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P16104
name: histone H2AX (human)
def: "A histone H2AX that is encoded in the genome of human." [PRO:DNx, UniProtKB:P16104]
comment: Category=organism-gene.
synonym: "H2AX" RELATED Gene-based [UniProtKB:P16104]
synonym: "H2AFX" RELATED Gene-based [UniProtKB:P16104]
synonym: "hH2AFX" EXACT PRO-short-label [PRO:DNx]
synonym: "H2a/x (human)" EXACT [UniProtKB:P16104]
synonym: "histone H2A.X (human)" EXACT [UniProtKB:P16104]
synonym: "histone H2A.x (human)" EXACT [PRO:DAN, UniProtKB:P16104]
xref: UniProtKB:P16104
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008418 ! histone H2AX
relationship: has_gene_template HGNC:4739 ! H2AFX (human)