[Term]
id: PR:P48506
name: glutamate--cysteine ligase catalytic subunit (human)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "GCLC" RELATED Gene-based [UniProtKB:P48506]
synonym: "GLCL" RELATED Gene-based [UniProtKB:P48506]
synonym: "GLCLC" RELATED Gene-based [UniProtKB:P48506]
synonym: "hGCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "gamma-ECS (human)" EXACT [UniProtKB:P48506]
synonym: "GCS heavy chain (human)" EXACT [UniProtKB:P48506]
synonym: "gamma-glutamylcysteine synthetase (human)" EXACT [UniProtKB:P48506]
xref: Reactome:R-HSA-174385 "PR:P48506 located_in GO:0005829"
xref: UniProtKB:P48506
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template HGNC:4311 ! GCLC (human)

[Term]
id: PR:Q09768
name: glutamate--cysteine ligase (Schizosaccharomyces pombe 972h-)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09768, PANTHER:PTHR11164:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "gcs1" RELATED Gene-based [UniProtKB:Q09768]
synonym: "SPAC22F3.10c" RELATED Gene-based [UniProtKB:Q09768]
synonym: "Spom972h-GCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "GCS (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09768]
synonym: "gamma-ECS (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09768]
synonym: "gamma-glutamylcysteine synthetase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09768]
xref: UniProtKB:Q09768
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template PomBase:SPAC22F3.10c ! gcs1 (Schizosaccharomyces pombe)

[Term]
id: PR:Q9W3K5
name: glutamate--cysteine ligase (fruit fly)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of fruit fly." [OMA:Q9W3K5, PANTHER:PTHR11164:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "GCSh" RELATED Gene-based [UniProtKB:Q9W3K5]
synonym: "Gclc" RELATED Gene-based [UniProtKB:Q9W3K5]
synonym: "CG2259" RELATED Gene-based [UniProtKB:Q9W3K5]
synonym: "fly-GCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "GCS (fruit fly)" EXACT [UniProtKB:Q9W3K5]
synonym: "gamma-ECS (fruit fly)" EXACT [UniProtKB:Q9W3K5]
synonym: "gamma-glutamylcysteine synthetase (fruit fly)" EXACT [UniProtKB:Q9W3K5]
xref: UniProtKB:Q9W3K5
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template FlyBase:FBgn0040319 ! Gclc (fruit fly)

[Term]
id: PR:Q20117
name: glutamate--cysteine ligase (worm)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of worm." [OMA:Q20117, PANTHER:PTHR11164:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "gcs-1" RELATED Gene-based [UniProtKB:Q20117]
synonym: "F37B12.2" RELATED Gene-based [UniProtKB:Q20117]
synonym: "GCS (worm)" EXACT [UniProtKB:Q20117]
synonym: "GCLC (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "gamma-ECS (worm)" EXACT [UniProtKB:Q20117]
synonym: "gamma-glutamylcysteine synthetase (worm)" EXACT [UniProtKB:Q20117]
xref: UniProtKB:Q20117
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template WormBase:WBGene00001527 ! gcs-1 (worm)

[Term]
id: PR:P32477
name: glutamate--cysteine ligase (yeast)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of yeast." [OMA:P32477, PANTHER:PTHR11164:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "GSH1" RELATED Gene-based [UniProtKB:P32477]
synonym: "J0832" RELATED Gene-based [UniProtKB:P32477]
synonym: "yGCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "YJL101C" RELATED Gene-based [UniProtKB:P32477]
synonym: "GCS (yeast)" EXACT [UniProtKB:P32477]
synonym: "gamma-ECS (yeast)" EXACT [UniProtKB:P32477]
synonym: "gamma-glutamylcysteine synthetase (yeast)" EXACT [UniProtKB:P32477]
xref: UniProtKB:P32477
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template SGD:S000003637 ! GSH1 (yeast)

[Term]
id: PR:000039544
name: glutamate--cysteine ligase catalytic subunit isoform 1
def: "A glutamate--cysteine ligase catalytic subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48506-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "GCLC/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007897 ! glutamate--cysteine ligase catalytic subunit

[Term]
id: PR:Q54PC2
name: glutamate--cysteine ligase (Dictyostelium discoideum)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54PC2, PANTHER:PTHR11164:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "gcsA" RELATED Gene-based [UniProtKB:Q54PC2]
synonym: "gshA" RELATED Gene-based [UniProtKB:Q54PC2]
synonym: "Dicty-GCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0284651" RELATED Gene-based [UniProtKB:Q54PC2]
synonym: "GCS (Dictyostelium discoideum)" EXACT [UniProtKB:Q54PC2]
synonym: "gamma-ECS (Dictyostelium discoideum)" EXACT [UniProtKB:Q54PC2]
synonym: "gamma-glutamylcysteine synthetase (Dictyostelium discoideum)" EXACT [UniProtKB:Q54PC2]
xref: UniProtKB:Q54PC2
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template dictyBase:DDB_G0284651 ! gcsA (Dictyostelium discoideum)

[Term]
id: PR:P19468-1
name: glutamate--cysteine ligase catalytic subunit isoform 1 (rat)
def: "A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rGCLC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19468-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039544 ! glutamate--cysteine ligase catalytic subunit isoform 1

[Term]
id: PR:P19468
name: glutamate--cysteine ligase catalytic subunit (rat)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of rat." [OMA:P19468, PANTHER:PTHR11164:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Gclc" RELATED Gene-based [UniProtKB:P19468]
synonym: "Glclc" RELATED Gene-based [UniProtKB:P19468]
synonym: "rGCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "gamma-ECS (rat)" EXACT [UniProtKB:P19468]
synonym: "GCS heavy chain (rat)" EXACT [UniProtKB:P19468]
synonym: "gamma-glutamylcysteine synthetase (rat)" EXACT [UniProtKB:P19468]
xref: UniProtKB:P19468
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template RGD:619868 ! Gclc (rat)

[Term]
id: PR:P97494-1
name: glutamate--cysteine ligase catalytic subunit isoform 1 (mouse)
def: "A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mGCLC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97494-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039544 ! glutamate--cysteine ligase catalytic subunit isoform 1

[Term]
id: PR:P97494
name: glutamate--cysteine ligase catalytic subunit (mouse)
def: "A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of mouse." [OMA:P97494, PRO:DNx]
comment: Category=organism-gene.
synonym: "Gclc" RELATED Gene-based [UniProtKB:P97494]
synonym: "Glclc" RELATED Gene-based [UniProtKB:P97494]
synonym: "mGCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "gamma-ECS (mouse)" EXACT [UniProtKB:P97494]
synonym: "GCS heavy chain (mouse)" EXACT [UniProtKB:P97494]
synonym: "gamma-glutamylcysteine synthetase (mouse)" EXACT [UniProtKB:P97494]
xref: UniProtKB:P97494
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007897 ! glutamate--cysteine ligase catalytic subunit
relationship: has_gene_template MGI:104990 ! Gclc (mouse)

[Term]
id: PR:000007897
name: glutamate--cysteine ligase catalytic subunit
def: "A protein that is a translation product of the human GCLC gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GCLC" EXACT PRO-short-label [PRO:DNx]
synonym: "GLCL" RELATED Gene-based []
synonym: "GLCLC" RELATED Gene-based []
synonym: "gamma-ECS" RELATED []
synonym: "GCS heavy chain" EXACT []
synonym: "gamma-glutamylcysteine synthetase" RELATED []
is_a: PR:000000001 ! protein

[Term]
id: PR:P48506-1
name: glutamate--cysteine ligase catalytic subunit isoform 1 (human)
def: "A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hGCLC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P48506-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039544 ! glutamate--cysteine ligase catalytic subunit isoform 1