[Term]
id: PR:000019828
name: coagulation factor XII, signal peptide removed form
def: "A coagulation factor XII that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "F12/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000007296 ! coagulation factor XII
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000019829
name: coagulation factor XII proteolytic cleavage product
def: "A coagulation factor XII that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "F12/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000007296 ! coagulation factor XII

[Term]
id: PR:000051242
name: coagulation factor XII O-glycosylated 6 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-328 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P00748-1, Thr-328, MOD:00005~GNO:G29068FM." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-328, MOD:00005~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051237
name: coagulation factor XII O-glycosylated 1 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Ser-335 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P00748-1, Ser-335, MOD:00002~GNO:G29068FM." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Ser-335, MOD:00002~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051239
name: coagulation factor XII O-glycosylated 3 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-299 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P00748-1, Thr-299, MOD:00005~GNO:G29068FM." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-299, MOD:00005~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051238
name: coagulation factor XII O-glycosylated 2 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Ser-335 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00748-1, Ser-335, MOD:00002~GNO:G43417UB." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Ser-335, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000007296
name: coagulation factor XII
def: "A protein that is a translation product of the human F12 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "F12" EXACT PRO-short-label [PRO:DNx]
synonym: "HAF" EXACT []
synonym: "hageman factor" EXACT []
xref: IUPHARobj:2361
is_a: PR:000000001 ! protein

[Term]
id: PR:Q80YC5
name: coagulation factor XII (mouse)
def: "A coagulation factor XII that is encoded in the genome of mouse." [OMA:Q80YC5, PANTHER:PTHR24265:SF32, PRO:DNx]
comment: Category=organism-gene.
synonym: "F12" RELATED Gene-based [UniProtKB:Q80YC5]
synonym: "mF12" EXACT PRO-short-label [PRO:DNx]
synonym: "HAF (mouse)" EXACT [UniProtKB:Q80YC5]
synonym: "hageman factor (mouse)" EXACT [UniProtKB:Q80YC5]
xref: UniProtKB:Q80YC5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007296 ! coagulation factor XII
relationship: has_gene_template MGI:1891012 ! F12 (mouse)

[Term]
id: PR:000051244
name: coagulation factor XII O-glycosylated 8 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-328 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P00748-1, Thr-328, MOD:00005~GNO:G58001LT." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:8" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-328, MOD:00005~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G58001LT ! G58001LT
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051245
name: coagulation factor XII O-glycosylated 9 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-337 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P00748-1, Thr-337, MOD:00005~GNO:G29068FM." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:9" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-337, MOD:00005~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051246
name: coagulation factor XII O-glycosylated 10 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-337 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00748-1, Thr-337, MOD:00005~GNO:G43417UB." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:10" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-337, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051247
name: coagulation factor XII O-glycosylated 11 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-43 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00748-1, Thr-43, MOD:00005~GNO:G43417UB." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:11" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-43, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051240
name: coagulation factor XII O-glycosylated 4 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-299 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P00748-1, Thr-299, MOD:00005~GNO:G53434XO." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-299, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051241
name: coagulation factor XII O-glycosylated 5 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-299 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P00748-1, Thr-299, MOD:00005~GNO:G58001LT." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-299, MOD:00005~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G58001LT ! G58001LT
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047348
name: coagulation factor XII, signal peptide removed form (human)
def: "A coagulation factor XII (human) that has had the signal peptide removed. UniProtKB:P00748, 20-615." [PRO:DNx, Reactome:R-HSA-158214]
comment: Category=organism-modification.
synonym: "hF12/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748, 20-615" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-158214 "PR:000047348 located_in GO:0005886"
intersection_of: PR:P00748 ! coagulation factor XII (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051243
name: coagulation factor XII O-glycosylated 7 (human)
def: "A coagulation factor XII (human) that has been O-glycosylated at the residue equivalent to Thr-328 of the amino acid sequence represented by UniProtKB:P00748-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P00748-1, Thr-328, MOD:00005~GNO:G53434XO." [GlyGen:P00748-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hF12/OGlyco:7" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00748-1, Thr-328, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00748 ! coagulation factor XII (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00748
name: coagulation factor XII (human)
def: "A coagulation factor XII that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00748]
comment: Category=organism-gene.
synonym: "F12" RELATED Gene-based [UniProtKB:P00748]
synonym: "hF12" EXACT PRO-short-label [PRO:DNx]
synonym: "HAF (human)" EXACT [UniProtKB:P00748]
synonym: "hageman factor (human)" EXACT [UniProtKB:P00748]
xref: UniProtKB:P00748
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007296 ! coagulation factor XII
relationship: has_gene_template HGNC:3530 ! F12 (human)

[Term]
id: PR:D3ZTE0
name: coagulation factor XII (rat)
def: "A coagulation factor XII that is encoded in the genome of rat." [OMA:D3ZTE0, PANTHER:PTHR24265:SF32, PRO:DNx]
comment: Category=organism-gene.
synonym: "F12" RELATED Gene-based [UniProtKB:D3ZTE0]
synonym: "rF12" EXACT PRO-short-label [PRO:DNx]
synonym: "HAF (rat)" EXACT [UniProtKB:D3ZTE0]
synonym: "hageman factor (rat)" EXACT [UniProtKB:D3ZTE0]
xref: UniProtKB:D3ZTE0
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007296 ! coagulation factor XII
relationship: has_gene_template RGD:1359175 ! F12 (rat)