[Term]
id: PR:000045630
name: estrogen receptor phosphorylated 1 (human)
def: "An estrogen receptor (human) that has been phosphorylated at the position equivalent to Tyr-537 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Tyr-537, MOD:00048." [PMID:7539106, iPTMnet:P03372]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:7539106). Status=unreviewed.
synonym: "hESR1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P03372-1, Tyr-537, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P03372 ! estrogen receptor (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19785
name: estrogen receptor (mouse)
def: "An estrogen receptor that is encoded in the genome of mouse." [OMA:P19785, PRO:DNx]
comment: Category=organism-gene.
synonym: "Esr" RELATED Gene-based [UniProtKB:P19785]
synonym: "Esr1" RELATED Gene-based [UniProtKB:P19785]
synonym: "Estr" RELATED Gene-based [UniProtKB:P19785]
synonym: "Estra" RELATED Gene-based [UniProtKB:P19785]
synonym: "Nr3a1" RELATED Gene-based [UniProtKB:P19785]
synonym: "mESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "ER (mouse)" EXACT [UniProtKB:P19785]
synonym: "ER-alpha (mouse)" EXACT [UniProtKB:P19785]
synonym: "estradiol receptor (mouse)" EXACT [UniProtKB:P19785]
synonym: "nuclear receptor subfamily 3 group A member 1 (mouse)" EXACT [UniProtKB:P19785]
xref: UniProtKB:P19785
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007204 ! estrogen receptor
relationship: has_gene_template MGI:1352467 ! Esr1 (mouse)

[Term]
id: PR:P57717
name: estrogen receptor (zebrafish)
def: "An estrogen receptor that is encoded in the genome of zebrafish." [PRO:DNx]
comment: Category=organism-gene.
synonym: "esr" RELATED Gene-based [UniProtKB:P57717]
synonym: "esr1" RELATED Gene-based [UniProtKB:P57717]
synonym: "nr3a1" RELATED Gene-based [UniProtKB:P57717]
synonym: "z-ESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "ER (zebrafish)" EXACT [UniProtKB:P57717]
synonym: "ER-alpha (zebrafish)" EXACT [UniProtKB:P57717]
synonym: "estradiol receptor (zebrafish)" EXACT [UniProtKB:P57717]
synonym: "nuclear receptor subfamily 3 group A member 1 (zebrafish)" EXACT [UniProtKB:P57717]
xref: UniProtKB:P57717
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000007204 ! estrogen receptor
relationship: has_gene_template ZFIN:ZDB-GENE-020806-5 ! esr1 (zebrafish)

[Term]
id: PR:000027775
name: estrogen receptor isoform 1 phosphorylated 4
def: "An estrogen receptor isoform 1 that has been phosphorylated on a Thr located in the helix 1 of the hormone binding domain. This highly conserved Thr residue is part of a leucine -rich nuclear export signal sequence and phosphorylation at this site blocks ERalpha nuclear export and promotes its transcriptional activation. Example: UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027777
name: estrogen receptor isoform 1 phosphorylated 5
def: "An estrogen receptor isoform 1 that has been phosphorylated at two Ser residues within the N-terminal activation function 1 (AF1) domain (Pfam:PF02159) in response to reactive oxygen species. Example: UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027776
name: estrogen receptor isoform 1 phosphorylated 4 (human)
def: "An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]
comment: Category=organism-modification. Kinase=("MAPK14"; PR:Q16539; Thr-311).
synonym: "pERalpha-Thr311" EXACT []
synonym: "hESR1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P03372-1, Thr-311, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027775 ! estrogen receptor isoform 1 phosphorylated 4
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027753
name: estrogen receptor isoform 1 phosphorylated 3
def: "An estrogen receptor isoform 1 that has been phosphorylated on a Ser residue in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This phosphorylation site is involved in modulating the expression of genes downregulated by 17-beta-estradiol and 4-Hydroxytamoxifen. Example: UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD, Pfam:PF02159]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027778
name: estrogen receptor isoform 1 phosphorylated 5 (human)
def: "An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]
comment: Category=organism-modification.
synonym: "hESR1/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "pERalpha-Ser118-Ser167" EXACT []
synonym: "UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027777 ! estrogen receptor isoform 1 phosphorylated 5
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027756
name: estrogen receptor isoform 1 acetylated 1 (human)
def: "An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]
comment: Category=organism-modification. Acetylase=("p300"; PR:000007102).
synonym: "hESR1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "AcK266/268-ERalpha (human)" EXACT []
synonym: "ERalpha acetylated (human)" RELATED []
synonym: "UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027755 ! estrogen receptor isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000027755
name: estrogen receptor isoform 1 acetylated 1
def: "An estrogen receptor isoform 1 that has been acetylated at two conserved lysine residues in the DNA- binding domain. Acetylation of these lysines increases the DNA- binding activity of estrogen receptor isoform 1. Example: UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]
comment: Category=modification.
synonym: "ESR1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "ERalpha acetylated" RELATED []
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000027754
name: estrogen receptor isoform 1 phosphorylated 3 (human)
def: "An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD]
comment: Category=organism-modification. Kinase=("MAPK"; PR:000000019).
synonym: "hESR1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P03372-1, Ser-118, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027753 ! estrogen receptor isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P03372-4
name: estrogen receptor isoform h4 (human)
def: "An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-4." [PRO:DNx, UniProtKB:P03372]
comment: Category=organism-sequence.
synonym: "hESR1/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "estrogen receptor isoform ER36 (human)" EXACT [UniProtKB:P03372]
synonym: "estrogen receptor isoform hER-alpha36 (human)" EXACT [UniProtKB:P03372]
xref: UniProtKB:P03372-4
xref: Reactome:R-HSA-9020981 "PR:P03372-4 located_in GO:0005829"
is_a: PR:P03372 ! estrogen receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000007204
name: estrogen receptor
def: "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ER" EXACT []
synonym: "ESR" RELATED Gene-based []
synonym: "ESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "Estr" RELATED Gene-based []
synonym: "Estra" RELATED Gene-based []
synonym: "NR3A1" RELATED Gene-based []
synonym: "ER-alpha" EXACT []
synonym: "estradiol receptor" EXACT []
synonym: "nuclear receptor subfamily 3 group A member 1" EXACT []
xref: IUPHARobj:620
is_a: PR:000000001 ! protein

[Term]
id: PR:P03372
name: estrogen receptor (human)
def: "An estrogen receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P03372]
comment: Category=organism-gene.
synonym: "ESR" RELATED Gene-based [UniProtKB:P03372]
synonym: "ESR1" RELATED Gene-based [UniProtKB:P03372]
synonym: "NR3A1" RELATED Gene-based [UniProtKB:P03372]
synonym: "hESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "ER (human)" EXACT [UniProtKB:P03372]
synonym: "ER-alpha (human)" EXACT [UniProtKB:P03372]
synonym: "estradiol receptor (human)" EXACT [UniProtKB:P03372]
synonym: "nuclear receptor subfamily 3 group A member 1 (human)" EXACT [UniProtKB:P03372]
xref: Reactome:R-HSA-446168 "PR:P03372 located_in GO:0005654"
xref: Reactome:R-HSA-9020968 "PR:P03372 located_in GO:0005829"
xref: DTO:00117511
xref: UniProtKB:P03372
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007204 ! estrogen receptor
relationship: has_gene_template HGNC:3467 ! ESR1 (human)

[Term]
id: PR:P03372-3
name: estrogen receptor isoform h3 (human)
def: "An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-3." [PRO:DNx, UniProtKB:P03372]
comment: Category=organism-sequence.
synonym: "hESR1/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "estrogen receptor isoform ER46 (human)" EXACT [UniProtKB:P03372]
synonym: "estrogen receptor isoform hER-alpha46 (human)" EXACT [UniProtKB:P03372]
xref: UniProtKB:P03372-3
xref: Reactome:R-HSA-9020984 "PR:P03372-3 located_in GO:0005829"
is_a: PR:P03372 ! estrogen receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P03372-2
name: estrogen receptor isoform h2 (human)
def: "An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-2." [PRO:DNx, UniProtKB:P03372]
comment: Category=organism-sequence.
synonym: "hESR1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "estrogen receptor isoform Short (human)" EXACT [UniProtKB:P03372]
xref: UniProtKB:P03372-2
is_a: PR:P03372 ! estrogen receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P03372-1
name: estrogen receptor isoform 1 (human)
def: "An estrogen receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hESR1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P03372-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027721 ! estrogen receptor isoform 1

[Term]
id: PR:P06212
name: estrogen receptor (chicken)
def: "An estrogen receptor that is encoded in the genome of chicken." [OMA:P06212, PANTHER:PTHR24084:SF217, PRO:DNx]
comment: Category=organism-gene.
synonym: "ESR" RELATED Gene-based [UniProtKB:P06212]
synonym: "ESR1" RELATED Gene-based [UniProtKB:P06212]
synonym: "NR3A1" RELATED Gene-based [UniProtKB:P06212]
synonym: "chick-ESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "ER (chicken)" EXACT [UniProtKB:P06212]
synonym: "ER-alpha (chicken)" EXACT [UniProtKB:P06212]
synonym: "estradiol receptor (chicken)" EXACT [UniProtKB:P06212]
synonym: "nuclear receptor subfamily 3 group A member 1 (chicken)" EXACT [UniProtKB:P06212]
xref: UniProtKB:P06212
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000007204 ! estrogen receptor
relationship: has_gene_template NCBIGene:396099 ! ESR1 (chicken)

[Term]
id: PR:P06211
name: estrogen receptor (rat)
def: "An estrogen receptor that is encoded in the genome of rat." [OMA:P06211, PANTHER:PTHR24084:SF217, PRO:DNx]
comment: Category=organism-gene.
synonym: "Esr" RELATED Gene-based [UniProtKB:P06211]
synonym: "Esr1" RELATED Gene-based [UniProtKB:P06211]
synonym: "Estr" RELATED Gene-based [UniProtKB:P06211]
synonym: "Nr3a1" RELATED Gene-based [UniProtKB:P06211]
synonym: "rESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "ER (rat)" EXACT [UniProtKB:P06211]
synonym: "ER-alpha (rat)" EXACT [UniProtKB:P06211]
synonym: "estradiol receptor (rat)" EXACT [UniProtKB:P06211]
synonym: "nuclear receptor subfamily 3 group A member 1 (rat)" EXACT [UniProtKB:P06211]
xref: UniProtKB:P06211
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007204 ! estrogen receptor
relationship: has_gene_template RGD:2581 ! Esr1 (rat)

[Term]
id: PR:P49884
name: estrogen receptor (cow)
def: "An estrogen receptor that is encoded in the genome of cow." [OMA:P49884, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "ESR" RELATED Gene-based [UniProtKB:P49884]
synonym: "ESR1" RELATED Gene-based [UniProtKB:P49884]
synonym: "NR3A1" RELATED Gene-based [UniProtKB:P49884]
synonym: "ER (cow)" EXACT [UniProtKB:P49884]
synonym: "cow-ESR1" EXACT PRO-short-label [PRO:DNx]
synonym: "ER-alpha (cow)" EXACT [UniProtKB:P49884]
synonym: "estradiol receptor (cow)" EXACT [UniProtKB:P49884]
synonym: "nuclear receptor subfamily 3 group A member 1 (cow)" EXACT [UniProtKB:P49884]
xref: UniProtKB:P49884
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000007204 ! estrogen receptor
relationship: has_gene_template NCBIGene:407238 ! ESR1 (cow)

[Term]
id: PR:000027723
name: estrogen receptor isoform 1 phosphorylated 1
def: "An estrogen receptor isoform 1 that has been phosphorylated at the Ser residue within the most C-terminal CK-2 phosphorylation consensus sequence S-x(2)-[DE] in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This is one of the major phosphorylation sites needed for activation of the receptor. Example: UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD, Pfam:PF02159]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027721
name: estrogen receptor isoform 1
def: "An estrogen receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-1 or a 1:1 ortholog thereof." [PMID:19940156, PRO:CNA]
comment: Category=sequence.
synonym: "ESR1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000007204 ! estrogen receptor

[Term]
id: PR:000027726
name: estrogen receptor isoform 1 phosphorylated 2 (human)
def: "An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]
comment: Category=organism-modification. Kinase=("ABL1"; PR:P00519).
synonym: "hESR1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027725 ! estrogen receptor isoform 1 phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000027724
name: estrogen receptor isoform 1 phosphorylated 1 (human)
def: "An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]
comment: Category=organism-modification. Kinase=("IKBKE"; PR:Q14164).
synonym: "hESR1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho-ERalpha-Ser-167" EXACT []
synonym: "UniProtKB:P03372-1, Ser-167, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027723 ! estrogen receptor isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027725
name: estrogen receptor isoform 1 phosphorylated 2
def: "An estrogen receptor isoform 1 that has been phosphorylated at the Tyr residue within the two YxxP motifs, on located in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159), the other in the zf-C4 (Pfam:PF00105) domain. Example: UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine