[Term]
id: PR:O75460
name: serine/threonine-protein kinase/endoribonuclease IRE1 (human)
def: "A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75460]
comment: Category=organism-gene.
synonym: "ERN1" RELATED Gene-based [UniProtKB:O75460]
synonym: "IRE1" RELATED Gene-based [UniProtKB:O75460]
synonym: "hERN1" EXACT PRO-short-label [PRO:DNx]
synonym: "hIRE1p" EXACT [UniProtKB:O75460]
synonym: "IRE1a (human)" EXACT [UniProtKB:O75460]
synonym: "Ire1-alpha (human)" EXACT [UniProtKB:O75460]
synonym: "inositol-requiring protein 1 (human)" EXACT [UniProtKB:O75460]
synonym: "endoplasmic reticulum-to-nucleus signaling 1 (human)" EXACT [UniProtKB:O75460]
xref: DTO:03100142
xref: UniProtKB:O75460
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007185 ! serine/threonine-protein kinase/endoribonuclease IRE1
relationship: has_gene_template HGNC:3449 ! ERN1 (human)

[Term]
id: PR:Q9EQY0
name: serine/threonine-protein kinase/endoribonuclease IRE1 (mouse)
def: "A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of mouse." [OMA:Q9EQY0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ern1" RELATED Gene-based [UniProtKB:Q9EQY0]
synonym: "Ire1" RELATED Gene-based [UniProtKB:Q9EQY0]
synonym: "mERN1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRE1a (mouse)" EXACT [UniProtKB:Q9EQY0]
synonym: "Ire1-alpha (mouse)" EXACT [UniProtKB:Q9EQY0]
synonym: "inositol-requiring protein 1 (mouse)" EXACT [UniProtKB:Q9EQY0]
synonym: "endoplasmic reticulum-to-nucleus signaling 1 (mouse)" EXACT [UniProtKB:Q9EQY0]
xref: UniProtKB:Q9EQY0
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007185 ! serine/threonine-protein kinase/endoribonuclease IRE1
relationship: has_gene_template MGI:1930134 ! Ern1 (mouse)

[Term]
id: PR:000007185
name: serine/threonine-protein kinase/endoribonuclease IRE1
def: "A protein that is a translation product of the human ERN1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ERN1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRE1" RELATED Gene-based []
synonym: "IRE1a" EXACT []
synonym: "IRE1p" EXACT []
synonym: "ire1-alpha" EXACT []
synonym: "inositol-requiring protein 1" EXACT []
synonym: "endoplasmic reticulum-to-nucleus signaling 1" EXACT []
xref: IUPHARobj:2020
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9EQY0-2
name: serine/threonine-protein kinase/endoribonuclease IRE1 isoform m2 (mouse)
def: "A serine/threonine-protein kinase/endoribonuclease IRE1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EQY0-2." [PRO:DNx, UniProtKB:Q9EQY0]
comment: Category=organism-sequence.
synonym: "mERN1/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EQY0-2
is_a: PR:Q9EQY0 ! serine/threonine-protein kinase/endoribonuclease IRE1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O75460-2
name: serine/threonine-protein kinase/endoribonuclease IRE1 isoform h2 (human)
def: "A serine/threonine-protein kinase/endoribonuclease IRE1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75460-2." [PRO:DNx, UniProtKB:O75460]
comment: Category=organism-sequence.
synonym: "hERN1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75460-2
is_a: PR:O75460 ! serine/threonine-protein kinase/endoribonuclease IRE1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O75460-1
name: serine/threonine-protein kinase/endoribonuclease IRE1 isoform h1 (human)
def: "A serine/threonine-protein kinase/endoribonuclease IRE1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75460-1." [PRO:DNx, UniProtKB:O75460]
comment: Category=organism-sequence.
synonym: "hERN1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75460-1
is_a: PR:O75460 ! serine/threonine-protein kinase/endoribonuclease IRE1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9EQY0-1
name: serine/threonine-protein kinase/endoribonuclease IRE1 isoform m1 (mouse)
def: "A serine/threonine-protein kinase/endoribonuclease IRE1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EQY0-1." [PRO:DNx, UniProtKB:Q9EQY0]
comment: Category=organism-sequence.
synonym: "mERN1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9EQY0-1
is_a: PR:Q9EQY0 ! serine/threonine-protein kinase/endoribonuclease IRE1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus