[Term]
id: PR:Q9UKV8-1
name: protein argonaute-2 isoform h1 (human)
def: "A protein argonaute-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKV8-1." [PRO:DNx, UniProtKB:Q9UKV8]
comment: Category=organism-sequence.
synonym: "hAGO2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UKV8-1
is_a: PR:Q9UKV8 ! protein argonaute-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9UKV8-2
name: protein argonaute-2 isoform h2 (human)
def: "A protein argonaute-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UKV8-2." [PRO:DNx, UniProtKB:Q9UKV8]
comment: Category=organism-sequence.
synonym: "hAGO2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UKV8-2
is_a: PR:Q9UKV8 ! protein argonaute-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9UKV8
name: protein argonaute-2 (human)
def: "A protein argonaute-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UKV8]
comment: Category=organism-gene.
synonym: "AGO2" RELATED Gene-based [UniProtKB:Q9UKV8]
synonym: "hAGO2" EXACT PRO-short-label [PRO:DNx]
synonym: "hAgo2" EXACT [UniProtKB:Q9UKV8]
synonym: "EIF2C2" RELATED Gene-based [UniProtKB:Q9UKV8]
synonym: "PPD (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "eIF2C 2 (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "eIF-2C 2 (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "Argonaute2 (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "protein slicer (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "PAZ Piwi domain protein (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "argonaute RISC catalytic component 2 (human)" EXACT [UniProtKB:Q9UKV8]
synonym: "eukaryotic translation initiation factor 2C 2 (human)" EXACT [UniProtKB:Q9UKV8]
xref: UniProtKB:Q9UKV8
xref: Reactome:R-HSA-209723 "PR:Q9UKV8 located_in GO:0005829"
xref: Reactome:R-HSA-5578701 "PR:Q9UKV8 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006968 ! protein argonaute-2
relationship: has_gene_template HGNC:3263 ! AGO2 (human)

[Term]
id: PR:Q9QZ81
name: protein argonaute-2 (rat)
def: "A protein argonaute-2 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-gene.
synonym: "Ago2" RELATED Gene-based [UniProtKB:Q9QZ81]
synonym: "rAGO2" EXACT PRO-short-label [PRO:DNx]
synonym: "Eif2c2" RELATED Gene-based [UniProtKB:Q9QZ81]
synonym: "GERp95 (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "eIF2C 2 (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "eIF-2C 2 (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "Argonaute2 (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "protein slicer (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "Golgi ER protein 95 kDa (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "argonaute RISC catalytic component 2 (rat)" EXACT [UniProtKB:Q9QZ81]
synonym: "eukaryotic translation initiation factor 2C 2 (rat)" EXACT [UniProtKB:Q9QZ81]
xref: UniProtKB:Q9QZ81
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006968 ! protein argonaute-2
relationship: has_gene_template RGD:621255 ! Ago2 (rat)

[Term]
id: PR:000006968
name: protein argonaute-2
def: "A protein that is a translation product of the human AGO2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PPD" EXACT []
synonym: "AGO2" EXACT PRO-short-label [PRO:DNx]
synonym: "Ago2" EXACT []
synonym: "EIF2C2" RELATED Gene-based []
synonym: "eIF2C 2" EXACT []
synonym: "Kiaa4215" RELATED Gene-based []
synonym: "eIF-2C 2" EXACT []
synonym: "Argonaute2" EXACT []
synonym: "protein slicer" EXACT []
synonym: "PAZ Piwi domain protein" EXACT []
synonym: "argonaute RISC catalytic component 2" EXACT []
synonym: "piwi/argonaute family protein meIF2C2" EXACT []
synonym: "eukaryotic translation initiation factor 2C 2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000046084
name: protein argonaute-2 phosphorylated 1 (human)
def: "A protein argonaute-2 (human) that has been phosphorylated at the position equivalent to Tyr-393 of the amino acid sequence represented by UniProtKB:Q9UKV8-1. Example: UniProtKB:Q9UKV8-1, Tyr-393, MOD:00048." [PMID:23636329, iPTMnet:Q9UKV8]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23636329). Status=unreviewed.
synonym: "hAGO2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9UKV8-1, Tyr-393, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9UKV8 ! protein argonaute-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8CJG0
name: protein argonaute-2 (mouse)
def: "A protein argonaute-2 that is encoded in the genome of mouse." [OMA:Q8CJG0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ago2" RELATED Gene-based [UniProtKB:Q8CJG0]
synonym: "mAGO2" EXACT PRO-short-label [PRO:DNx]
synonym: "mAgo2" EXACT [UniProtKB:Q8CJG0]
synonym: "Eif2c2" RELATED Gene-based [UniProtKB:Q8CJG0]
synonym: "Kiaa4215" RELATED Gene-based [UniProtKB:Q8CJG0]
synonym: "eIF2C 2 (mouse)" EXACT [UniProtKB:Q8CJG0]
synonym: "eIF-2C 2 (mouse)" EXACT [UniProtKB:Q8CJG0]
synonym: "Argonaute2 (mouse)" EXACT [UniProtKB:Q8CJG0]
synonym: "protein slicer (mouse)" EXACT [UniProtKB:Q8CJG0]
synonym: "argonaute RISC catalytic component 2 (mouse)" EXACT [UniProtKB:Q8CJG0]
synonym: "piwi/argonaute family protein meIF2C2 (mouse)" EXACT [UniProtKB:Q8CJG0]
synonym: "eukaryotic translation initiation factor 2C 2 (mouse)" EXACT [UniProtKB:Q8CJG0]
xref: UniProtKB:Q8CJG0
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006968 ! protein argonaute-2
relationship: has_gene_template MGI:2446632 ! Ago2 (mouse)