[Term]
id: PR:000006910
name: elongation factor 2 kinase
def: "A protein that is a translation product of the human EEF2K gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "EEF2K" EXACT PRO-short-label [PRO:DNx]
synonym: "eEF-2K" EXACT []
synonym: "eEF-2 kinase" EXACT []
synonym: "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase" EXACT []
xref: IUPHARobj:2014
is_a: PR:000000001 ! protein

[Term]
id: PR:O08796-1
name: eukaryotic elongation factor 2 kinase isoform 1 (mouse)
def: "An elongation factor 2 kinase isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mEEF2K/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O08796-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000037959 ! elongation factor 2 kinase isoform 1

[Term]
id: PR:O01991
name: eukaryotic elongation factor 2 kinase (worm)
def: "An elongation factor 2 kinase that is encoded in the genome of worm." [OMA:O01991, PANTHER:PTHR14187:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "efk-1" RELATED Gene-based [UniProtKB:O01991]
synonym: "F42A10.4" RELATED Gene-based [UniProtKB:O01991]
synonym: "EEF2K (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "eEF-2K (worm)" EXACT [UniProtKB:O01991]
synonym: "eEF-2 kinase (worm)" EXACT [UniProtKB:O01991]
synonym: "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase (worm)" EXACT [UniProtKB:O01991]
xref: UniProtKB:O01991
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000006910 ! elongation factor 2 kinase
relationship: has_gene_template WormBase:WBGene00001160 ! efk-1 (worm)

[Term]
id: PR:O01991-2
name: eukaryotic elongation factor 2 kinase isoform b (worm)
def: "A eukaryotic elongation factor 2 kinase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O01991-2." [PRO:DNx, UniProtKB:O01991]
comment: Category=organism-sequence.
synonym: "EEF2K/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O01991-2
is_a: PR:O01991 ! eukaryotic elongation factor 2 kinase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P70531
name: eukaryotic elongation factor 2 kinase (rat)
def: "An elongation factor 2 kinase that is encoded in the genome of rat." [OMA:P70531, PANTHER:PTHR14187:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Eef2k" RELATED Gene-based [UniProtKB:P70531]
synonym: "rEEF2K" EXACT PRO-short-label [PRO:DNx]
synonym: "eEF-2K (rat)" EXACT [UniProtKB:P70531]
synonym: "eEF-2 kinase (rat)" EXACT [UniProtKB:P70531]
synonym: "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase (rat)" EXACT [UniProtKB:P70531]
xref: UniProtKB:P70531
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006910 ! elongation factor 2 kinase
relationship: has_gene_template RGD:2538 ! Eef2k (rat)

[Term]
id: PR:000037959
name: elongation factor 2 kinase isoform 1
def: "An elongation factor 2 kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08796-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "EEF2K/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000006910 ! elongation factor 2 kinase

[Term]
id: PR:000047251
name: eukaryotic elongation factor 2 kinase phosphorylated 2 (human)
def: "A eukaryotic elongation factor 2 kinase (human) that has been post-translationally modified to include phosphoserine at position 366 of the amino acid sequence represented by UniProtKB:O00418. UniProtKB:O00418, Ser-366, MOD:00046." [PRO:DNx, Reactome:R-HSA-165755]
comment: Category=organism-modification.
synonym: "hEEF2K/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00418, Ser-366, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-165755 "PR:000047251 located_in GO:0005829"
is_a: PR:O00418 ! eukaryotic elongation factor 2 kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00418
name: eukaryotic elongation factor 2 kinase (human)
def: "An elongation factor 2 kinase that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00418]
comment: Category=organism-gene.
synonym: "EEF2K" RELATED Gene-based [UniProtKB:O00418]
synonym: "hEEF2K" EXACT PRO-short-label [PRO:DNx]
synonym: "eEF-2K (human)" EXACT [UniProtKB:O00418]
synonym: "eEF-2 kinase (human)" EXACT [UniProtKB:O00418]
synonym: "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase (human)" EXACT [UniProtKB:O00418]
xref: Reactome:R-HSA-165745 "PR:O00418 located_in GO:0005829"
xref: DTO:03100122
xref: UniProtKB:O00418
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006910 ! elongation factor 2 kinase
relationship: has_gene_template HGNC:24615 ! EEF2K (human)

[Term]
id: PR:000045559
name: eukaryotic elongation factor 2 kinase phosphorylated 1 (human)
def: "A eukaryotic elongation factor 2 kinase (human) that has been phosphorylated at Ser-398. UniProtKB:O00418, Ser-398, MOD:00046." [PMID:23182879, iPTMnet:O00418]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23182879). Status=unreviewed.
synonym: "hEEF2K/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00418, Ser-398, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O00418 ! eukaryotic elongation factor 2 kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O01991-1
name: eukaryotic elongation factor 2 kinase isoform a (worm)
def: "A eukaryotic elongation factor 2 kinase (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O01991-1." [PRO:DNx, UniProtKB:O01991]
comment: Category=organism-sequence.
synonym: "EEF2K/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O01991-1
is_a: PR:O01991 ! eukaryotic elongation factor 2 kinase (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P70531-1
name: eukaryotic elongation factor 2 kinase isoform 1 (rat)
def: "An elongation factor 2 kinase isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rEEF2K/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70531-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000037959 ! elongation factor 2 kinase isoform 1

[Term]
id: PR:O08796
name: eukaryotic elongation factor 2 kinase (mouse)
def: "An elongation factor 2 kinase that is encoded in the genome of mouse." [OMA:O08796, PRO:DNx]
comment: Category=organism-gene.
synonym: "Eef2k" RELATED Gene-based [UniProtKB:O08796]
synonym: "mEEF2K" EXACT PRO-short-label [PRO:DNx]
synonym: "eEF-2K (mouse)" EXACT [UniProtKB:O08796]
synonym: "eEF-2 kinase (mouse)" EXACT [UniProtKB:O08796]
synonym: "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase (mouse)" EXACT [UniProtKB:O08796]
xref: UniProtKB:O08796
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006910 ! elongation factor 2 kinase
relationship: has_gene_template MGI:1195261 ! Eef2k (mouse)