[Term]
id: PR:O96017-2
name: serine/threonine-protein kinase Chk2 isoform h2 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-2." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform ins2 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-2
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-3
name: serine/threonine-protein kinase Chk2 isoform h3 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-3." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform del2-12 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-3
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-1
name: serine/threonine-protein kinase Chk2 isoform h1 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-1." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O96017-1
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-10
name: serine/threonine-protein kinase Chk2 isoform h10 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-10." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h10" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform iso2 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-10
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-11
name: serine/threonine-protein kinase Chk2 isoform h11 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-11." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h11" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform iso1 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-11
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-12
name: serine/threonine-protein kinase Chk2 isoform h12 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-12." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h12" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform del9 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-12
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-13
name: serine/threonine-protein kinase Chk2 isoform h13 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-13." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h13" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O96017-13
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045624
name: serine/threonine-protein kinase Chk2 phosphorylated 1 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that has been phosphorylated at the position equivalent to Thr-68 of the amino acid sequence represented by UniProtKB:O96017-1. Example: UniProtKB:O96017-1, Thr-68, MOD:00047." [PMID:11085506, PMID:11668173, PMID:11901158, PMID:15342622, PMID:15533933, PMID:16311512, iPTMnet:O96017]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11085506, PMID:11668173, PMID:11901158, PMID:15342622, PMID:15533933, PMID:16311512). Status=unreviewed.
synonym: "hCHEK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O96017-1, Thr-68, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-113825 "PR:000045624 located_in GO:0005654"
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-5
name: serine/threonine-protein kinase Chk2 isoform h5 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-5." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform del4 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-5
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000005418
name: serine/threonine-protein kinase Chk2
def: "A protein that is a translation product of the human CHEK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CDS1" RELATED Gene-based []
synonym: "CHK2" RELATED Gene-based []
synonym: "cds1" EXACT []
synonym: "CHEK2" EXACT PRO-short-label [PRO:DNx]
synonym: "RAD53" RELATED Gene-based []
synonym: "checkpoint kinase 2" EXACT []
synonym: "CHK2 checkpoint homolog" EXACT []
xref: IUPHARobj:1988
is_a: PR:000000001 ! protein

[Term]
id: PR:000046702
name: serine/threonine-protein kinase Chk2 phosphorylated 2 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that has been post-translationally modified to include phosphothreonine at positions 68, 383 and 387, and phosphoserine at position 379 of the amino acid sequence represented by UniProtKB:O96017. UniProtKB:O96017, Thr-68/Thr-383/Thr-387, MOD:00047|Ser-379, MOD:00046." [PRO:DNx, Reactome:R-HSA-5683784]
comment: Category=organism-modification.
synonym: "hCHEK2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O96017, Thr-68/Thr-383/Thr-387, MOD:00047|Ser-379, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5683784 "PR:000046702 located_in GO:0005654"
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017
name: serine/threonine-protein kinase Chk2 (human)
def: "A serine/threonine-protein kinase Chk2 that is encoded in the genome of human." [OMA:O96017, PRO:DNx]
comment: Category=organism-gene.
synonym: "CDS1" RELATED Gene-based [UniProtKB:O96017]
synonym: "CHK2" RELATED Gene-based [UniProtKB:O96017]
synonym: "CHEK2" RELATED Gene-based [UniProtKB:O96017]
synonym: "RAD53" RELATED Gene-based [UniProtKB:O96017]
synonym: "hCds1" EXACT [UniProtKB:O96017]
synonym: "hCHEK2" EXACT PRO-short-label [PRO:DNx]
synonym: "Hucds1 (human)" EXACT [UniProtKB:O96017]
synonym: "Cds1 homolog (human)" EXACT [UniProtKB:O96017]
synonym: "checkpoint kinase 2 (human)" EXACT [UniProtKB:O96017]
synonym: "CHK2 checkpoint homolog (human)" EXACT [UniProtKB:O96017]
xref: DTO:03100083
xref: UniProtKB:O96017
xref: Reactome:R-HSA-113824 "PR:O96017 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005418 ! serine/threonine-protein kinase Chk2
relationship: has_gene_template HGNC:16627 ! CHEK2 (human)

[Term]
id: PR:O96017-6
name: serine/threonine-protein kinase Chk2 isoform h6 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-6." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform sub3 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-6
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-9
name: serine/threonine-protein kinase Chk2 isoform h9 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-9." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h9" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform insx (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-9
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-4
name: serine/threonine-protein kinase Chk2 isoform h4 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-4." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform del2-3 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-4
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-8
name: serine/threonine-protein kinase Chk2 isoform h8 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-8." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h8" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform del7 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-8
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O96017-7
name: serine/threonine-protein kinase Chk2 isoform h7 (human)
def: "A serine/threonine-protein kinase Chk2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96017-7." [PRO:DNx, UniProtKB:O96017]
comment: Category=organism-sequence.
synonym: "hCHEK2/iso:h7" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk2 isoform del9-12 (human)" EXACT [UniProtKB:O96017]
xref: UniProtKB:O96017-7
is_a: PR:O96017 ! serine/threonine-protein kinase Chk2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens