[Term]
id: PR:000005374
name: complement factor B
def: "A protein that is a translation product of the human CFB gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BF" RELATED Gene-based []
synonym: "BFD" RELATED Gene-based []
synonym: "CFB" EXACT PRO-short-label [PRO:DNx]
synonym: "GBG" EXACT []
synonym: "PBF2" EXACT []
synonym: "H2-Bf" RELATED Gene-based []
synonym: "C3/C5 convertase" RELATED []
synonym: "properdin factor B" EXACT []
synonym: "glycine-rich beta glycoprotein" EXACT []
xref: IUPHARobj:2339
is_a: PR:000000001 ! protein

[Term]
id: PR:000051365
name: complement factor B O-glycosylated 2 (human)
def: "A complement factor B (human) that has been O-glycosylated at the residue equivalent to Thr-26 of the amino acid sequence represented by UniProtKB:P00751-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00751-1, Thr-26, MOD:00005~GNO:G43417UB." [GlyGen:P00751-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCFB/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00751-1, Thr-26, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00751 ! complement factor B (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046693
name: complement factor B, signal peptide removed form (human)
def: "A complement factor B (human) that has had the signal peptide removed. UniProtKB:P00751, 26-764." [PRO:DNx, Reactome:R-HSA-173738]
comment: Category=organism-modification.
synonym: "hCFB/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000027545" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P00751, 26-764" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-173738 "PR:000046693 located_in GO:0005576"
intersection_of: PR:P00751 ! complement factor B (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000019307
name: complement factor B, signal peptide removed form
def: "A complement factor B that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "CFB/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000005374 ! complement factor B
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000051364
name: complement factor B O-glycosylated 1 (human)
def: "A complement factor B (human) that has been O-glycosylated at the residue equivalent to Thr-25 of the amino acid sequence represented by UniProtKB:P00751-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P00751-1, Thr-25, MOD:00005~GNO:G53434XO." [GlyGen:P00751-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCFB/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00751-1, Thr-25, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00751 ! complement factor B (human)
relationship: has_part GNO:G53434XO ! G53434XO
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051363
name: complement factor B N-glycosylated 1 (human)
def: "A complement factor B (human) that has been N-glycosylated at the residue equivalent to Asn-285 of the amino acid sequence represented by UniProtKB:P00751-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00751-1, Asn-285, MOD:00160~GNO:G00912UN." [GlyGen:P00751-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCFB/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00751-1, Asn-285, MOD:00160~GNO:G00912UN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P00751 ! complement factor B (human)
relationship: has_part GNO:G00912UN ! G00912UN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00751-2
name: complement factor B isoform h2 (human)
def: "A complement factor B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00751-2." [PRO:DNx, UniProtKB:P00751]
comment: Category=organism-sequence.
synonym: "hCFB/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00751-2
is_a: PR:P00751 ! complement factor B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P00751
name: complement factor B (human)
def: "A complement factor B that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00751]
comment: Category=organism-gene.
synonym: "BF" RELATED Gene-based [UniProtKB:P00751]
synonym: "BFD" RELATED Gene-based [UniProtKB:P00751]
synonym: "CFB" RELATED Gene-based [UniProtKB:P00751]
synonym: "hCFB" EXACT PRO-short-label [PRO:DNx]
synonym: "GBG (human)" EXACT [UniProtKB:P00751]
synonym: "PBF2 (human)" EXACT [UniProtKB:P00751]
synonym: "C3/C5 convertase (human)" BROAD [UniProtKB:P00751]
synonym: "properdin factor B (human)" EXACT [UniProtKB:P00751]
synonym: "glycine-rich beta glycoprotein (human)" EXACT [UniProtKB:P00751]
xref: UniProtKB:P00751
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005374 ! complement factor B
relationship: has_gene_template HGNC:1037 ! CFB (human)

[Term]
id: PR:000019308
name: complement factor B proteolytic cleavage product
def: "A complement factor B that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "CFB/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000005374 ! complement factor B

[Term]
id: PR:P04186
name: complement factor B (mouse)
def: "A complement factor B that is encoded in the genome of mouse." [OMA:P04186, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bf" RELATED Gene-based [UniProtKB:P04186]
synonym: "Cfb" RELATED Gene-based [UniProtKB:P04186]
synonym: "mCFB" EXACT PRO-short-label [PRO:DNx]
synonym: "H2-Bf" RELATED Gene-based [UniProtKB:P04186]
synonym: "C3/C5 convertase (mouse)" RELATED [UniProtKB:P04186]
xref: UniProtKB:P04186
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005374 ! complement factor B
relationship: has_gene_template MGI:105975 ! Cfb (mouse)

[Term]
id: PR:P00751-1
name: complement factor B isoform h1 (human)
def: "A complement factor B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00751-1." [PRO:DNx, UniProtKB:P00751]
comment: Category=organism-sequence.
synonym: "hCFB/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P00751-1
is_a: PR:P00751 ! complement factor B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens