[Term]
id: PR:Q63699-1
name: cyclin-dependent kinase 2 isoform rCDK2-alpha (rat)
def: "A cyclin-dependent kinase 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63699-1." [PRO:DNx, UniProtKB:Q63699]
comment: Category=organism-sequence.
synonym: "rCDK2/iso:rCDK2-alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q63699-1
is_a: PR:Q63699 ! cyclin-dependent kinase 2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q63699
name: cyclin-dependent kinase 2 (rat)
def: "A cyclin-dependent kinase 2 that is encoded in the genome of rat." [OMA:Q63699, PRO:DAN]
comment: Category=organism-gene.
synonym: "Cdk2" RELATED Gene-based [UniProtKB:Q63699]
synonym: "Cdkn2" RELATED Gene-based [UniProtKB:Q63699]
synonym: "rCDK2" EXACT PRO-short-label [PRO:DNx]
synonym: "cell division protein kinase 2 (rat)" EXACT [UniProtKB:Q63699]
xref: UniProtKB:Q63699
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000005253 ! cyclin-dependent kinase 2
relationship: has_gene_template RGD:70486 ! Cdk2 (rat)

[Term]
id: PR:000043632
name: cyclin-dependent kinase 2 phosphorylated form (human)
def: "A cyclin-dependent kinase 2 phosphorylated form in human. UniProtKB:P24941, MOD:00696." [PRO:DAN]
comment: Category=organism-modification.
synonym: "hCDK2/PhosRes+" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P24941, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-68370 "PR:000043632 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000045380 ! cyclin-dependent kinase 2 phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000005253
name: cyclin-dependent kinase 2
def: "A CDK2-related kinase that is a translation product of the human CDK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CDK2" EXACT PRO-short-label [PRO:DNx]
synonym: "CDKN2" RELATED Gene-based []
synonym: "p33 protein kinase" RELATED []
synonym: "cell division protein kinase 2" EXACT []
xref: IUPHARobj:1973
is_a: PR:000003270 ! CDK2-related kinase

[Term]
id: PR:000045724
name: cyclin-dependent kinase 2 phosphorylated 1 (human)
def: "A cyclin-dependent kinase 2 (human) that has been phosphorylated at the position equivalent to Thr-160 of the amino acid sequence represented by UniProtKB:P24941-1. Example: UniProtKB:P24941-1, Thr-160, MOD:00047." [PMID:12359725, PMID:14597612, PMID:17361108, PMID:8443411, iPTMnet:P24941]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12359725, PMID:14597612, PMID:17361108, PMID:8443411). Status=unreviewed.
synonym: "hCDK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P24941-1, Thr-160, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-187967 "PR:000045724 located_in GO:0005654"
is_a: PR:P24941 ! cyclin-dependent kinase 2 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045380
name: cyclin-dependent kinase 2 phosphorylated form
def: "A cyclin-dependent kinase 2 that includes at least one phosphorylated residue." [PRO:DAN]
comment: Category=modification.
synonym: "CDK2/PhosRes+" EXACT PRO-short-label [PRO:DAN]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000005253 ! cyclin-dependent kinase 2

[Term]
id: PR:P24941-1
name: cyclin-dependent kinase 2 isoform h1 (human)
def: "A cyclin-dependent kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24941-1." [PRO:DNx, UniProtKB:P24941]
comment: Category=organism-sequence.
synonym: "hCDK2/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P24941-1
is_a: PR:P24941 ! cyclin-dependent kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P97377-1
name: cyclin-dependent kinase 2 isoform 1 (mouse)
def: "A cyclin-dependent kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "mCDK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97377-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000028800 ! cyclin-dependent kinase 2 isoform 1

[Term]
id: PR:P23573
name: cyclin-dependent kinase 2 (fruit fly)
def: "A cyclin-dependent kinase 2 that is encoded in the genome of fruit fly." [PRO:DNx]
comment: Category=organism-gene.
synonym: "Cdk2" RELATED Gene-based [UniProtKB:P23573]
synonym: "cdc2c" RELATED Gene-based [UniProtKB:P23573]
synonym: "CG10498" RELATED Gene-based [UniProtKB:P23573]
synonym: "fly-CDK2" EXACT PRO-short-label [PRO:DNx]
synonym: "cell division control protein 2 cognate (fruit fly)" EXACT [UniProtKB:P23573]
xref: UniProtKB:P23573
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000005253 ! cyclin-dependent kinase 2
relationship: has_gene_template FlyBase:FBgn0004107 ! Cdk2 (fruit fly)

[Term]
id: PR:Q63699-2
name: cyclin-dependent kinase 2 isoform rCDK2-beta (rat)
def: "A cyclin-dependent kinase 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63699-2." [PRO:DNx, UniProtKB:Q63699]
comment: Category=organism-sequence.
synonym: "rCDK2/iso:rCDK2-beta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q63699-2
is_a: PR:Q63699 ! cyclin-dependent kinase 2 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P97377-2
name: cyclin-dependent kinase 2 isoform mCDK2-alpha (mouse)
def: "A cyclin-dependent kinase 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97377-2." [PRO:DNx, UniProtKB:P97377]
comment: Category=organism-sequence.
synonym: "mCDK2/iso:mCDK2-alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97377-2
is_a: PR:P97377 ! cyclin-dependent kinase 2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P24941-2
name: cyclin-dependent kinase 2 isoform h2 (human)
def: "A cyclin-dependent kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24941-2." [PRO:DNx, UniProtKB:P24941]
comment: Category=organism-sequence.
synonym: "hCDK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase 2 isoform CDK2deltaT (human)" EXACT [UniProtKB:P24941]
xref: UniProtKB:P24941-2
is_a: PR:P24941 ! cyclin-dependent kinase 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046674
name: cyclin-dependent kinase 2 phosphorylated 2 (human)
def: "A cyclin-dependent kinase 2 (human) that has been post-translationally modified to include phosphotyrosine at position 15 of the amino acid sequence represented by UniProtKB:P24941. UniProtKB:P24941, Tyr-15, MOD:00048." [PRO:DNx, Reactome:R-HSA-187905]
comment: Category=organism-modification.
synonym: "hCDK2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P24941, Tyr-15, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-187905 "PR:000046674 located_in GO:0005654"
is_a: PR:P24941 ! cyclin-dependent kinase 2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028802
name: cyclin-dependent kinase 2 isoform 1 acetylated 1
def: "A cyclin-dependent kinase 2 isoform 1 that has been acetylated on a Lys residue within the catalytic pocket. Example: UniProtKB:P97377-1, Lys-33, MOD:00064." [PMID:19773423, PRO:PD]
comment: Category=modification.
synonym: "CDK2/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028800 ! cyclin-dependent kinase 2 isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028803
name: cyclin-dependent kinase 2 isoform 1 acetylated 1 (human)
def: "A cyclin-dependent kinase 2 isoform 1 acetylated 1 in human. Acetylation inhibits CDK2 activity. UniProtKB:P24941-1, Lys-33, MOD:00064." [PMID:19773423, PRO:PD]
comment: Category=organism-modification. Acetylase=("KAT2B"; PR:000012332).
synonym: "hCDK2/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P24941-1, Lys-33, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028802 ! cyclin-dependent kinase 2 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000028800
name: cyclin-dependent kinase 2 isoform 1
def: "A cyclin-dependent kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97377-1 or a 1:1 ortholog thereof." [PMID:19773423, PRO:PD]
comment: Category=sequence.
synonym: "CDK2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005253 ! cyclin-dependent kinase 2

[Term]
id: PR:P97377
name: cyclin-dependent kinase 2 (mouse)
def: "A cyclin-dependent kinase 2 that is encoded in the genome of mouse." [OMA:P97377, PRO:DAN]
comment: Category=organism-gene.
synonym: "Cdk2" RELATED Gene-based [UniProtKB:P97377]
synonym: "Cdkn2" RELATED Gene-based [UniProtKB:P97377]
synonym: "mCDK2" EXACT PRO-short-label [PRO:DNx]
synonym: "cell division protein kinase 2 (mouse)" EXACT [UniProtKB:P97377]
xref: UniProtKB:P97377
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005253 ! cyclin-dependent kinase 2
relationship: has_gene_template MGI:104772 ! Cdk2 (mouse)

[Term]
id: PR:P24941
name: cyclin-dependent kinase 2 (human)
def: "A cyclin-dependent kinase 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "CDK2" RELATED Gene-based [UniProtKB:P24941]
synonym: "CDKN2" RELATED Gene-based [UniProtKB:P24941]
synonym: "hCDK2" EXACT PRO-short-label [PRO:DNx]
synonym: "p33 protein kinase (human)" EXACT [UniProtKB:P24941]
synonym: "cell division protein kinase 2 (human)" EXACT []
xref: Reactome:R-HSA-68365 "PR:P24941 located_in GO:0005654"
xref: Reactome:R-HSA-157440 "PR:P24941 located_in GO:0005829"
xref: DTO:03100068
xref: UniProtKB:P24941
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005253 ! cyclin-dependent kinase 2
relationship: has_gene_template HGNC:1771 ! CDK2 (human)