[Term]
id: PR:Q6GPC9
name: mitotic checkpoint serine/threonine-protein kinase BUB1 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of frog." [PRO:DNx, UniProtKB:Q6GPC9]
comment: Category=organism-gene.
synonym: "bub1" RELATED Gene-based [UniProtKB:Q6GPC9]
synonym: "bub1.L" RELATED Gene-based [PRO:DAN]
synonym: "LOC398234" RELATED Gene-based [UniProtKB:Q6GPC9]
synonym: "frog-bub1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q6GPC9
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template NCBIGene:398234 ! bub1 (frog)

[Term]
id: PR:000029917
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in frog." [PRO:CNA]
comment: Category=organism-modification.
synonym: "frog-BUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

[Term]
id: PR:Q98UH3
name: mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q98UH3." [PMID:11231148, PRO:DAN, PRO:KER]
comment: Category=organism-sequence. Note: There are multiple positions of variation with respect to the reference sequence (UniProtKB:Q6GPC9-1).
synonym: "frog-BUB1/var:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q98UH3
is_a: PR:Q6GPC9 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (frog)
relationship: only_in_taxon NCBITaxon:8355 ! Xenopus laevis

[Term]
id: PR:000029913
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in frog." [PMID:11231148, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1"; PR:Q98UH3).
synonym: "frog-BUB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "xBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000029912 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000029911
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER]
comment: Category=organism-modification. Kinase=("RPS6KA"; PR:P10665).
synonym: "frog-BUB1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "xBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000029910 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000004854
name: mitotic checkpoint serine/threonine-protein kinase BUB1
def: "A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]
comment: Category=gene.
synonym: "BUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1A" EXACT []
synonym: "BUB1L" RELATED Gene-based []
xref: IUPHARobj:1949
is_a: PR:000035665 ! BUB1/BUB1B protein

[Term]
id: PR:000035404
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]
comment: Category=organism-modification. Phosphorylation at Ser-500 is the most critical for checkpoint function. This form is observed during spindle disruption (nocodazole). Kinase=("MAPK"; PR:000000019).
synonym: "frog-BUB1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "xBUB1 hyperphosphorylated" RELATED []
synonym: "UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000035403 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine