[Term]
id: PR:000025659
name: beta-2-microglobulin isoform 1
def: "A beta-2-microglobulin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61769-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "B2M/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004580 ! beta-2-microglobulin

[Term]
id: PR:000019110
name: beta-2-microglobulin proteolytic cleavage product
def: "A beta-2-microglobulin that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "B2M/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000004580 ! beta-2-microglobulin

[Term]
id: PR:P61769
name: beta-2-microglobulin (human)
def: "A beta-2-microglobulin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P61769]
comment: Category=organism-gene.
synonym: "B2M" RELATED Gene-based [UniProtKB:P61769]
synonym: "hB2M" EXACT PRO-short-label [PRO:DNx]
synonym: "HDCMA22P" RELATED Gene-based [UniProtKB:P61769]
synonym: "CDABP0092" RELATED Gene-based [UniProtKB:P61769]
xref: UniProtKB:P61769
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004580 ! beta-2-microglobulin
relationship: has_gene_template HGNC:914 ! B2M (human)

[Term]
id: PR:P01887
name: beta-2-microglobulin (mouse)
def: "A beta-2-microglobulin that is encoded in the genome of mouse." [OMA:P01887, PRO:DNx]
comment: Category=organism-gene.
synonym: "B2m" RELATED Gene-based [UniProtKB:P01887]
synonym: "mB2M" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01887
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000004580 ! beta-2-microglobulin
relationship: has_gene_template MGI:88127 ! B2m (mouse)

[Term]
id: PR:000026597
name: beta-2-microglobulin isoform 1, signal peptide removed form
def: "A beta-2-microglobulin isoform 1 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "B2M/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000025659 ! beta-2-microglobulin isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000019109
name: beta-2-microglobulin, signal peptide removed form
def: "A beta-2-microglobulin that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "B2M/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000004580 ! beta-2-microglobulin
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P07151
name: beta-2-microglobulin (rat)
def: "A beta-2-microglobulin that is encoded in the genome of rat." [OMA:P07151, PRO:DNx]
comment: Category=organism-gene.
synonym: "B2m" RELATED Gene-based [UniProtKB:P07151]
synonym: "rB2M" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07151
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000004580 ! beta-2-microglobulin
relationship: has_gene_template RGD:2189 ! B2m (rat)

[Term]
id: PR:P61769-1
name: beta-2-microglobulin isoform 1 (human)
def: "A beta-2-microglobulin isoform 1 that is encoded in the genome of human." [PMID:17968930, SALO:AJ]
comment: Category=organism-sequence. Salivary Sjogren's syndrome biomarker.
synonym: "hB2M/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P61769-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025659 ! beta-2-microglobulin isoform 1

[Term]
id: PR:000004580
name: beta-2-microglobulin
def: "A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "B2M" EXACT PRO-short-label [PRO:DNx]
synonym: "HDCMA22P" RELATED Gene-based []
synonym: "CDABP0092" RELATED Gene-based []
is_a: PR:000000001 ! protein

[Term]
id: PR:000036227
name: beta-2-microglobulin acetylated 1 (human)
def: "A beta-2-microglobulin that is N-terminal Met acetylated in human. UniProtKB:P61769, Met-1, MOD:00058." [TDR:1687]
comment: Category=organism-modification. Note: Top down proteomics. Evidence=(ECO:0000006).
synonym: "hB2M/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P61769, Met-1, MOD:00058" EXACT PRO-proteoform-std [PRO:DNx]
xref: TDR:1687
xref: TDR:16320
is_a: PR:000004580 ! beta-2-microglobulin
relationship: has_part MOD:00058 ! N-acetyl-L-methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q04475
name: beta-2-microglobulin (zebrafish)
def: "A beta-2-microglobulin that is encoded in the genome of zebrafish." [PRO:DNx]
comment: Category=organism-gene.
synonym: "b2m" RELATED Gene-based [UniProtKB:Q04475]
synonym: "z-B2M" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04475
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000004580 ! beta-2-microglobulin
relationship: has_gene_template ZFIN:ZDB-GENE-980526-88 ! b2m (zebrafish)

[Term]
id: PR:P21611
name: beta-2-microglobulin (chicken)
def: "A beta-2-microglobulin that is encoded in the genome of chicken." [OMA:P21611, PRO:DNx]
comment: Category=organism-gene.
synonym: "B2M" RELATED Gene-based [UniProtKB:P21611]
synonym: "chick-B2M" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21611
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000004580 ! beta-2-microglobulin
relationship: has_gene_template NCBIGene:414830 ! B2M (chicken)

[Term]
id: PR:000046452
name: beta-2-microglobulin, signal peptide removed form (human)
def: "A beta-2-microglobulin (human) that has had the signal peptide removed. UniProtKB:P61769, 21-119." [PRO:DNx, Reactome:R-HSA-1236827, Reactome:R-HSA-1236891, Reactome:R-HSA-1302721, Reactome:R-HSA-167743, Reactome:R-HSA-182298, Reactome:R-HSA-8863880, Reactome:R-HSA-983063, Reactome:R-HSA-983378, Reactome:R-HSA-983403]
comment: Category=organism-modification.
synonym: "hB2M/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000018779" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P61769, 21-119" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-182298 "PR:000046452 located_in GO:0031901"
xref: Reactome:R-HSA-167743 "PR:000046452 located_in GO:0005886"
xref: Reactome:R-HSA-983063 "PR:000046452 located_in GO:0005788"
xref: Reactome:R-HSA-983378 "PR:000046452 located_in GO:0012507"
xref: Reactome:R-HSA-983403 "PR:000046452 located_in GO:0000139"
xref: Reactome:R-HSA-1236827 "PR:000046452 located_in GO:0031905"
xref: Reactome:R-HSA-1236891 "PR:000046452 located_in GO:0030670"
xref: Reactome:R-HSA-1302721 "PR:000046452 located_in GO:0005576"
xref: Reactome:R-HSA-6800179 "PR:000046452 located_in GO:1904724"
xref: Reactome:R-HSA-6806144 "PR:000046452 located_in GO:0035580"
xref: Reactome:R-HSA-8863880 "PR:000046452 located_in GO:0055038"
xref: TDR:1015
intersection_of: PR:P61769 ! beta-2-microglobulin (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01887-1
name: beta-2-microglobulin isoform 1 (mouse)
def: "A beta-2-microglobulin isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mB2M/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01887-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000025659 ! beta-2-microglobulin isoform 1