[Term]
id: PR:000038855
name: angiotensinogen isoform 1
def: "An angiotensinogen that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11859-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "AGT/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003847 ! angiotensinogen

[Term]
id: PR:P11859
name: angiotensinogen (mouse)
def: "An angiotensinogen that is encoded in the genome of mouse." [OMA:P11859, PRO:DNx]
comment: Category=organism-gene.
synonym: "Agt" RELATED Gene-based [UniProtKB:P11859]
synonym: "mAGT" EXACT PRO-short-label [PRO:DNx]
synonym: "Serpina8" RELATED Gene-based [UniProtKB:P11859]
synonym: "serpin A8 (mouse)" EXACT [UniProtKB:P11859]
xref: UniProtKB:P11859
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003847 ! angiotensinogen
relationship: has_gene_template MGI:87963 ! Agt (mouse)

[Term]
id: PR:000051448
name: angiotensinogen O-glycosylated 1 (human)
def: "An angiotensinogen (human) that has been O-glycosylated at the residue equivalent to Thr-440 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01019-1, Thr-440, MOD:00005~GNO:G43417UB." [GlyGen:P01019-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Thr-440, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036009
name: angiotensin II
def: "An angiotensinogen proteolytic cleavage product that is formed via the action of angiotensin converting enzyme on angiotensin I." [PMID:18793332, PRO:DAN]
comment: Category=modification. In humans and other mammals, the sequence is DRVYIHPF. This is the active hormone, the mature peptide.
synonym: "ang II" EXACT PRO-short-label [PRO:DAN]
synonym: "angiotensin 2" EXACT []
synonym: "angiotensin 1-8" EXACT []
synonym: "mature angiotensin" EXACT []
is_a: PR:000018932 ! angiotensinogen proteolytic cleavage product
relationship: derives_from PR:000036008 ! angiotensin I

[Term]
id: PR:000036008
name: angiotensin I
def: "An angiotensinogen proteolytic cleavage product that is formed via the action of renin on angiotensinogen, signal peptide removed form." [PMID:18793332, PRO:DAN]
comment: Category=modification. In humans and other mammals, the sequence is DRVYIHPFHL.
synonym: "ang I" EXACT PRO-short-label [PRO:DAN]
synonym: "angiotensin 1-10" EXACT []
is_a: PR:000018932 ! angiotensinogen proteolytic cleavage product
relationship: derives_from PR:000018931 ! angiotensinogen, signal peptide removed form

[Term]
id: PR:000051442
name: angiotensinogen N-glycosylated 1 (human)
def: "An angiotensinogen (human) that has been N-glycosylated at the residue equivalent to Asn-47 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G00912UN." [GlyGen:P01019-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G00912UN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G00912UN ! G00912UN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051443
name: angiotensinogen N-glycosylated 2 (human)
def: "An angiotensinogen (human) that has been N-glycosylated at the residue equivalent to Asn-47 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G08293MJ." [GlyGen:P01019-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G08293MJ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G08293MJ ! G08293MJ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051446
name: angiotensinogen N-glycosylated 5 (human)
def: "An angiotensinogen (human) that has been N-glycosylated at the residue equivalent to Asn-47 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G40926MX. Example: UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G40926MX." [GlyGen:P01019-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/NGlyco:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G40926MX" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G40926MX ! G40926MX
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051447
name: angiotensinogen N-glycosylated 6 (human)
def: "An angiotensinogen (human) that has been N-glycosylated at the residue equivalent to Asn-47 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G59626AS." [GlyGen:P01019-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/NGlyco:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G59626AS" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G59626AS ! G59626AS
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051444
name: angiotensinogen N-glycosylated 3 (human)
def: "An angiotensinogen (human) that has been N-glycosylated at the residue equivalent to Asn-47 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G10486CT." [GlyGen:P01019-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/NGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G10486CT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G10486CT ! G10486CT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000051445
name: angiotensinogen N-glycosylated 4 (human)
def: "An angiotensinogen (human) that has been N-glycosylated at the residue equivalent to Asn-47 of the amino acid sequence represented by UniProtKB:P01019-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G27947YN." [GlyGen:P01019-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hAGT/NGlyco:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01019-1, Asn-47, MOD:00160~GNO:G27947YN" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01019 ! angiotensinogen (human)
relationship: has_part GNO:G27947YN ! G27947YN
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046285
name: angiotensinogen, signal peptide removed form (human)
def: "An angiotensinogen (human) that has had the signal peptide removed. UniProtKB:P01019, 34-485." [PRO:DNx, Reactome:R-HSA-1998759]
comment: Category=organism-modification.
synonym: "hAGT/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000032456" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P01019, 34-485" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1998759 "PR:000046285 located_in GO:0005576"
intersection_of: PR:P01019 ! angiotensinogen (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01019
name: angiotensinogen (human)
def: "An angiotensinogen that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01019]
comment: Category=organism-gene.
synonym: "AGT" RELATED Gene-based [UniProtKB:P01019]
synonym: "hAGT" EXACT PRO-short-label [PRO:DNx]
synonym: "SERPINA8" RELATED Gene-based [UniProtKB:P01019]
synonym: "serpin A8 (human)" EXACT [UniProtKB:P01019]
xref: UniProtKB:P01019
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003847 ! angiotensinogen
relationship: has_gene_template HGNC:333 ! AGT (human)

[Term]
id: PR:P11859-1
name: angiotensinogen isoform 1 (mouse)
def: "An angiotensinogen isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mAGT/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11859-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038855 ! angiotensinogen isoform 1

[Term]
id: PR:P01015
name: angiotensinogen (rat)
def: "An angiotensinogen that is encoded in the genome of rat." [OMA:P01015, PANTHER:PTHR11461:SF13, PRO:DNx]
comment: Category=organism-gene.
synonym: "Agt" RELATED Gene-based [UniProtKB:P01015]
synonym: "rAGT" EXACT PRO-short-label [PRO:DNx]
synonym: "Serpina8" RELATED Gene-based [UniProtKB:P01015]
synonym: "serpin A8 (rat)" EXACT [UniProtKB:P01015]
xref: UniProtKB:P01015
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003847 ! angiotensinogen
relationship: has_gene_template RGD:2069 ! Agt (rat)

[Term]
id: PR:P01015-1
name: angiotensinogen isoform 1 (rat)
def: "An angiotensinogen isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rAGT/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01015-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038855 ! angiotensinogen isoform 1

[Term]
id: PR:000018931
name: angiotensinogen, signal peptide removed form
def: "An angiotensinogen that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "AGT/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "angiotensinogen" RELATED []
intersection_of: PR:000003847 ! angiotensinogen
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000003847
name: angiotensinogen
def: "A serpin that is a translation product of the human AGT gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "AGT" EXACT PRO-short-label [PRO:DNx]
synonym: "SERPINA8" RELATED Gene-based []
synonym: "serpin A8" EXACT []
synonym: "preangiotensinogen" RELATED []
is_a: PR:000025875 ! serpin

[Term]
id: PR:000018932
name: angiotensinogen proteolytic cleavage product
def: "An angiotensinogen, signal peptide removed form that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "AGT/ClvPrd" EXACT PRO-short-label [PRO:DAN]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000018931 ! angiotensinogen, signal peptide removed form

[Term]
id: PR:000036012
name: angiotensin 1-9
def: "An angiotensinogen proteolytic cleavage product that is formed via the action of angiotensin converting enzyme 2 on angiotensin I." [PMID:18793332, PRO:DAN]
comment: Category=modification. In humans and other mammals, the sequence is DRVYIHPFH.
synonym: "ang 1-9" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000018932 ! angiotensinogen proteolytic cleavage product
relationship: derives_from PR:000036008 ! angiotensin I

[Term]
id: PR:000036013
name: angiotensin 1-7
def: "An angiotensinogen proteolytic cleavage product that is formed via the action of angiotensin converting enzyme 2 on angiotensin II." [PMID:18793332, PRO:DAN]
comment: Category=modification. In humans and other mammals, the sequence is DRVYIHP.
synonym: "ang 1-7" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000018932 ! angiotensinogen proteolytic cleavage product
relationship: derives_from PR:000036009 ! angiotensin II

[Term]
id: PR:000036010
name: angiotensin III
def: "An angiotensinogen proteolytic cleavage product that is formed via the action of aminopeptidase A on angiotensin II." [PMID:18793332, PRO:DAN]
comment: Category=modification. In humans and other mammals, the sequence is RVYIHPF.
synonym: "ang III" EXACT PRO-short-label [PRO:DAN]
synonym: "angiotensin 3" EXACT []
synonym: "angiotensin 2-8" EXACT []
is_a: PR:000018932 ! angiotensinogen proteolytic cleavage product
relationship: derives_from PR:000036009 ! angiotensin II

[Term]
id: PR:000036011
name: angiotensin IV
def: "An angiotensinogen proteolytic cleavage product that is formed via the action of aminopeptidase M on angiotensin III." [PMID:18793332, PRO:DAN]
comment: Category=modification. In humans and other mammals, the sequence is VYIHPF.
synonym: "ang IV" EXACT PRO-short-label [PRO:DAN]
synonym: "angiotensin 4" EXACT []
synonym: "angiotensin 3-8" EXACT []
is_a: PR:000018932 ! angiotensinogen proteolytic cleavage product
relationship: derives_from PR:000036010 ! angiotensin III