[Term]
id: PR:000003293
name: NF-kappa-B inhibitor alpha
def: "An NF-kappa-B inhibitor that is a translation product of the human NFKBIA gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM]
comment: Category=gene. Requested by=TLR.
synonym: "IKBA" RELATED Gene-based []
synonym: "MAD3" RELATED Gene-based []
synonym: "NFKBI" RELATED Gene-based []
synonym: "NFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "IKBalpha" EXACT []
synonym: "IkB-alpha" EXACT []
synonym: "IkappaBalpha" EXACT []
synonym: "I-kappa-B-alpha" EXACT []
synonym: "major histocompatibility complex enhancer-binding protein MAD3" EXACT []
is_a: PR:000003292 ! NF-kappa-B inhibitor

[Term]
id: PR:P25963
name: NF-kappa-B inhibitor alpha (human)
def: "An NF-kappa-B inhibitor alpha that is encoded in the genome of human." [TLR:AMM, UniProtKB:P25963]
comment: Category=organism-gene.
synonym: "IKBA" RELATED Gene-based [UniProtKB:P25963]
synonym: "MAD3" RELATED Gene-based [UniProtKB:P25963]
synonym: "NFKBI" RELATED Gene-based [UniProtKB:P25963]
synonym: "NFKBIA" RELATED Gene-based [UniProtKB:P25963]
synonym: "hNFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "IkB-alpha (human)" EXACT [UniProtKB:P25963]
synonym: "IkappaBalpha (human)" EXACT [UniProtKB:P25963]
synonym: "I-kappa-B-alpha (human)" EXACT [UniProtKB:P25963]
synonym: "major histocompatibility complex enhancer-binding protein MAD3 (human)" EXACT [UniProtKB:P25963]
xref: Reactome:R-HSA-168151 "PR:P25963 located_in GO:0005829"
xref: Reactome:R-HSA-4656929 "PR:P25963 located_in GO:0005654"
xref: UniProtKB:P25963
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003293 ! NF-kappa-B inhibitor alpha
relationship: has_gene_template HGNC:7797 ! NFKBIA (human)

[Term]
id: PR:000028546
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)
def: "An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]
comment: Category=organism-modification. Kinase=("IKK complex"; PR:000026457).
synonym: "hNFKBIA/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028545 ! NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000045728
name: NF-kappa-B inhibitor alpha phosphorylated 1 (human)
def: "An NF-kappa-B inhibitor alpha (human) that has been phosphorylated at Tyr-42. UniProtKB:P25963, Tyr-42, MOD:00048." [PMID:12429743, PMID:12432072, iPTMnet:P25963]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12429743, PMID:12432072). Status=unreviewed.
synonym: "hNFKBIA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25963, Tyr-42, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P25963 ! NF-kappa-B inhibitor alpha (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028548
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)
def: "An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]
comment: Category=organism-modification.
synonym: "hNFKBIA/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitinated phospho-IKb (human)" RELATED []
synonym: "UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028547 ! NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000048597
name: NF-kappa-B inhibitor alpha ubiquitinated form (human)
def: "An NF-kappa-B inhibitor alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P25963, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782960]
comment: Category=organism-modification.
synonym: "hNFKBIA/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25963, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782960 "PR:000048597 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P25963 ! NF-kappa-B inhibitor alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P25963-1
name: NF-kappa-B inhibitor alpha isoform 1 (human)
def: "An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNFKBIA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25963-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028543 ! NF-kappa-B inhibitor alpha isoform 1