[Term]
id: PR:000003283
name: dual specificity mitogen-activated protein kinase kinase 4
def: "A protein that is a translation product of the human MAP2K4 gene or a 1:1 ortholog thereof." [TLR:AMM]
comment: Category=gene. Requested by=TLR.
synonym: "JNKK" EXACT []
synonym: "MEK4" RELATED Gene-based []
synonym: "MKK4" RELATED Gene-based []
synonym: "SEK1" RELATED Gene-based []
synonym: "SKK1" RELATED Gene-based []
synonym: "JNKK1" RELATED Gene-based []
synonym: "MEK 4" EXACT []
synonym: "SERK1" RELATED Gene-based []
synonym: "JNKK 1" EXACT []
synonym: "MAP2K4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKMK4" RELATED Gene-based []
synonym: "MAPKK 4" EXACT []
synonym: "JNK kinase 1" EXACT []
synonym: "MAPK/ERK kinase 4" EXACT []
synonym: "SAPK/ERK kinase 1" EXACT []
synonym: "MAP kinase kinase 4" EXACT []
synonym: "JNK-activating kinase 1" EXACT []
synonym: "c-Jun N-terminal kinase kinase 1" EXACT []
xref: IUPHARobj:2065
is_a: PR:000000001 ! protein

[Term]
id: PR:000021996
name: dual specificity mitogen-activated protein kinase kinase 4 phosphorylated 1
def: "A dual specificity mitogen-activated protein kinase kinase 4 phosphorylated form in which the phosphorylation occurs on Ser/Thr residues within the activation loop by MAP kinase kinase kinases." [PMID:10785355, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "MKK4 active" EXACT []
synonym: "MAP2K4/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000021995 ! dual specificity mitogen-activated protein kinase kinase 4 phosphorylated form

[Term]
id: PR:000021995
name: dual specificity mitogen-activated protein kinase kinase 4 phosphorylated form
def: "A dual specificity mitogen-activated protein kinase kinase 4 that includes at least one phosphorylated residue." [TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "MAP2K4/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003283 ! dual specificity mitogen-activated protein kinase kinase 4

[Term]
id: PR:P45985
name: dual specificity mitogen-activated protein kinase kinase 4 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human." [TLR:AMM, UniProtKB:P45985]
comment: Category=organism-gene.
synonym: "MEK4" RELATED Gene-based [UniProtKB:P45985]
synonym: "MKK4" RELATED Gene-based [UniProtKB:P45985]
synonym: "SEK1" RELATED Gene-based [UniProtKB:P45985]
synonym: "SKK1" RELATED Gene-based [UniProtKB:P45985]
synonym: "JNKK1" RELATED Gene-based [UniProtKB:P45985]
synonym: "SERK1" RELATED Gene-based [UniProtKB:P45985]
synonym: "MAP2K4" RELATED Gene-based [UniProtKB:P45985]
synonym: "PRKMK4" RELATED Gene-based [UniProtKB:P45985]
synonym: "hMAP2K4" EXACT PRO-short-label [PRO:DNx]
synonym: "JNKK (human)" EXACT [UniProtKB:P45985]
synonym: "MEK 4 (human)" EXACT [UniProtKB:P45985]
synonym: "SAPKK1 (human)" EXACT [UniProtKB:P45985]
synonym: "MAPKK 4 (human)" EXACT [UniProtKB:P45985]
synonym: "SAPKK-1 (human)" EXACT [UniProtKB:P45985]
synonym: "SAPK kinase 1 (human)" EXACT [UniProtKB:P45985]
synonym: "MAPK/ERK kinase 4 (human)" EXACT [UniProtKB:P45985]
synonym: "SAPK/ERK kinase 1 (human)" EXACT [UniProtKB:P45985]
synonym: "MAP kinase kinase 4 (human)" EXACT [UniProtKB:P45985]
synonym: "JNK-activating kinase 1 (human)" EXACT [UniProtKB:P45985]
synonym: "c-Jun N-terminal kinase kinase 1 (human)" EXACT [UniProtKB:P45985]
synonym: "stress-activated protein kinase kinase 1 (human)" EXACT [UniProtKB:P45985]
xref: Reactome:R-HSA-168107 "PR:P45985 located_in GO:0005829"
xref: DTO:03100337
xref: UniProtKB:P45985
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003283 ! dual specificity mitogen-activated protein kinase kinase 4
relationship: has_gene_template HGNC:6844 ! MAP2K4 (human)

[Term]
id: PR:Q20347
name: MAP kinase kinase mkk-4 (worm)
def: "A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of worm." [OMA:Q20347, PRO:DNx]
comment: Category=organism-gene.
synonym: "mkk-4" RELATED Gene-based [UniProtKB:Q20347]
synonym: "F42G10.2" RELATED Gene-based [UniProtKB:Q20347]
synonym: "MAP2K4 (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q20347
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000003283 ! dual specificity mitogen-activated protein kinase kinase 4
relationship: has_gene_template WormBase:WBGene00003368 ! mkk-4 (worm)

[Term]
id: PR:000018804
name: dual specificity mitogen-activated protein kinase kinase 4, initiator methionine removed form
def: "A dual specificity mitogen-activated protein kinase kinase 4 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "MAP2K4/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003283 ! dual specificity mitogen-activated protein kinase kinase 4
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P47809
name: dual specificity mitogen-activated protein kinase kinase 4 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of mouse." [OMA:P47809, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mek4" RELATED Gene-based [UniProtKB:P47809]
synonym: "Mkk4" RELATED Gene-based [UniProtKB:P47809]
synonym: "Sek1" RELATED Gene-based [UniProtKB:P47809]
synonym: "Skk1" RELATED Gene-based [UniProtKB:P47809]
synonym: "Jnkk1" RELATED Gene-based [UniProtKB:P47809]
synonym: "Serk1" RELATED Gene-based [UniProtKB:P47809]
synonym: "Map2k4" RELATED Gene-based [UniProtKB:P47809]
synonym: "Prkmk4" RELATED Gene-based [UniProtKB:P47809]
synonym: "mMAP2K4" EXACT PRO-short-label [PRO:DNx]
synonym: "SEK1 (mouse)" EXACT [UniProtKB:P47809]
synonym: "MEK 4 (mouse)" EXACT [UniProtKB:P47809]
synonym: "JNKK 1 (mouse)" EXACT [UniProtKB:P47809]
synonym: "MAPKK 4 (mouse)" EXACT [UniProtKB:P47809]
synonym: "JNK kinase 1 (mouse)" EXACT [UniProtKB:P47809]
synonym: "MAPK/ERK kinase 4 (mouse)" EXACT [UniProtKB:P47809]
synonym: "SAPK/ERK kinase 1 (mouse)" EXACT [UniProtKB:P47809]
synonym: "MAP kinase kinase 4 (mouse)" EXACT [UniProtKB:P47809]
synonym: "JNK-activating kinase 1 (mouse)" EXACT [UniProtKB:P47809]
synonym: "C-JUN N-terminal kinase kinase 1 (mouse)" EXACT [UniProtKB:P47809]
xref: UniProtKB:P47809
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003283 ! dual specificity mitogen-activated protein kinase kinase 4
relationship: has_gene_template MGI:1346869 ! Map2k4 (mouse)

[Term]
id: PR:000048298
name: dual specificity mitogen-activated protein kinase kinase 4 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 4 (human) that has been post-translationally modified to include phosphoserine at position 257, and phosphothreonine at position 261 of the amino acid sequence represented by UniProtKB:P45985. UniProtKB:P45985, Ser-257, MOD:00046|Thr-261, MOD:00047." [PRO:DNx, Reactome:R-HSA-168170]
comment: Category=organism-modification.
synonym: "hMAP2K4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P45985, Ser-257, MOD:00046|Thr-261, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-168170 "PR:000048298 located_in GO:0005829"
is_a: PR:P45985 ! dual specificity mitogen-activated protein kinase kinase 4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P45985-2
name: dual specificity mitogen-activated protein kinase kinase 4 isoform h2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P45985-2." [PRO:DNx, UniProtKB:P45985]
comment: Category=organism-sequence.
synonym: "hMAP2K4/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P45985-2
is_a: PR:P45985 ! dual specificity mitogen-activated protein kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P45985-1
name: dual specificity mitogen-activated protein kinase kinase 4 isoform h1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P45985-1." [PRO:DNx, UniProtKB:P45985]
comment: Category=organism-sequence.
synonym: "hMAP2K4/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P45985-1
is_a: PR:P45985 ! dual specificity mitogen-activated protein kinase kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens