[Term]
id: PR:000003118
name: proto-oncogene vav
def: "A protein that is a translation product of the human VAV1 gene or a 1:1 ortholog thereof. Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation." [PRO:CL, UniProtKB:P15498]
comment: Category=gene.
synonym: "VAV" RELATED Gene-based []
synonym: "VAV1" EXACT PRO-short-label [PRO:DNx]
synonym: "p95vav" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P15498-1
name: proto-oncogene vav isoform 1 (human)
def: "A proto-oncogene vav isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hVAV1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P15498-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038933 ! proto-oncogene vav isoform 1

[Term]
id: PR:P15498-2
name: proto-oncogene vav isoform h2 (human)
def: "A proto-oncogene vav (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15498-2." [PRO:DNx, UniProtKB:P15498]
comment: Category=organism-sequence.
synonym: "hVAV1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P15498-2
is_a: PR:P15498 ! proto-oncogene vav (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045684
name: proto-oncogene vav phosphorylated 1 (human)
def: "A proto-oncogene vav (human) that has been phosphorylated at the position equivalent to Tyr-267 of the amino acid sequence represented by UniProtKB:P15498-1. Example: UniProtKB:P15498-1, Tyr-267, MOD:00048." [PMID:23325923, iPTMnet:P15498]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23325923). Status=unreviewed.
synonym: "hVAV1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15498-1, Tyr-267, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P15498 ! proto-oncogene vav (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049643
name: proto-oncogene vav phosphorylated 3 (human)
def: "A proto-oncogene vav (human) that has been post-translationally modified to include phosphotyrosine at position 174 of the amino acid sequence represented by UniProtKB:P15498. UniProtKB:P15498, Tyr-174, MOD:00048." [PRO:DNx, Reactome:R-HSA-437946]
comment: Category=organism-modification.
synonym: "hVAV1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15498, Tyr-174, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-437946 "PR:000049643 located_in GO:0005829"
is_a: PR:P15498 ! proto-oncogene vav (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049642
name: proto-oncogene vav phosphorylated 2 (human)
def: "A proto-oncogene vav (human) that has been post-translationally modified to include phosphotyrosine at positions 142, 160 and 174 of the amino acid sequence represented by UniProtKB:P15498. UniProtKB:P15498, Tyr-142/Tyr-160/Tyr-174, MOD:00048." [PRO:DNx, Reactome:R-HSA-389323]
comment: Category=organism-modification.
synonym: "hVAV1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15498, Tyr-142/Tyr-160/Tyr-174, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-389323 "PR:000049642 located_in GO:0005886"
is_a: PR:P15498 ! proto-oncogene vav (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P15498
name: proto-oncogene vav (human)
def: "A proto-oncogene vav that is encoded in the genome of human." [PRO:CL, UniProtKB:P15498]
comment: Category=organism-gene.
synonym: "VAV" RELATED Gene-based [UniProtKB:P15498]
synonym: "VAV1" RELATED Gene-based [UniProtKB:P15498]
synonym: "hVAV1" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-195066 "PR:P15498 located_in GO:0005829"
xref: Reactome:R-HSA-1045153 "PR:P15498 located_in GO:0005886"
xref: UniProtKB:P15498
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003118 ! proto-oncogene vav
relationship: has_gene_template HGNC:12657 ! VAV1 (human)