[Term]
id: PR:P43405
name: tyrosine-protein kinase SYK (human)
def: "A tyrosine-protein kinase SYK that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43405]
comment: Category=organism-gene.
synonym: "SYK" RELATED Gene-based [UniProtKB:P43405]
synonym: "hSYK" EXACT PRO-short-label [PRO:DNx]
synonym: "p72-Syk (human)" EXACT [UniProtKB:P43405]
synonym: "spleen tyrosine kinase (human)" EXACT [UniProtKB:P43405]
xref: Reactome:R-HSA-58268 "PR:P43405 located_in GO:0005829"
xref: DTO:03100262
xref: UniProtKB:P43405
xref: Reactome:R-HSA-139844 "PR:P43405 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003065 ! tyrosine-protein kinase SYK
relationship: has_gene_template HGNC:11491 ! SYK (human)

[Term]
id: PR:P43405-1
name: tyrosine-protein kinase SYK isoform Long (human)
def: "A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hSYK/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43405-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025832 ! tyrosine-protein kinase SYK isoform 1

[Term]
id: PR:P43405-2
name: tyrosine-protein kinase SYK isoform Short (human)
def: "A tyrosine-protein kinase SYK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43405-2." [PRO:DNx, UniProtKB:P43405]
comment: Category=organism-sequence.
synonym: "hSYK/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43405-2
is_a: PR:P43405 ! tyrosine-protein kinase SYK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003065
name: tyrosine-protein kinase SYK
def: "A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human SYK gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "SYK" EXACT PRO-short-label [PRO:DNx]
synonym: "spleen tyrosine kinase" EXACT []
xref: IUPHARobj:2230
is_a: PR:000003063 ! SYK/ZAP-70 family tyrosine-protein kinase

[Term]
id: PR:000049392
name: tyrosine-protein kinase SYK phosphotyrosine form (human)
def: "A tyrosine-protein kinase SYK (human) that includes at least one phosphorylated tyrosine. UniProtKB:P43405, MOD:00048." [PRO:DNx, Reactome:R-HSA-429432]
comment: Category=organism-modification.
synonym: "hSYK/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43405, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-429432 "PR:000049392 located_in GO:0005886"
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:P43405 ! tyrosine-protein kinase SYK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049391
name: tyrosine-protein kinase SYK phosphorylated 3 (human)
def: "A tyrosine-protein kinase SYK (human) that has been post-translationally modified to include phosphotyrosine at positions 131, 323, 348, 352, 525 and 526 of the amino acid sequence represented by UniProtKB:P43405. UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048." [PRO:DNx, Reactome:R-HSA-1861712, Reactome:R-HSA-983586]
comment: Category=organism-modification.
synonym: "hSYK/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43405, Tyr-131/Tyr-323/Tyr-348/Tyr-352/Tyr-525/Tyr-526, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-983586 "PR:000049391 located_in GO:0005886"
xref: Reactome:R-HSA-1861712 "PR:000049391 located_in GO:0005829"
is_a: PR:P43405 ! tyrosine-protein kinase SYK (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026221
name: tyrosine-protein kinase SYK phosphorylated 2 (human)
def: "A tyrosine-protein kinase SYK phosphorylated 2 in human. UniProtKB:P43405, Tyr-348, MOD:00048." [PRO:CNx, Reactome:R-HSA-437953]
comment: Category=organism-modification.
synonym: "hSYK/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43405, Tyr-348, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-437953 "PR:000026221 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026193 ! tyrosine-protein kinase SYK phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine