[Term] id: PR:P43403-3 name: tyrosine-protein kinase ZAP-70 isoform h3 (human) def: "A tyrosine-protein kinase ZAP-70 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-3." [PRO:DNx, UniProtKB:P43403] comment: Category=organism-sequence. synonym: "hZAP70/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P43403-3 is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P43403 name: tyrosine-protein kinase ZAP-70 (human) def: "A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human." [PRO:CL, UniProtKB:P43403] comment: Category=organism-gene. synonym: "SRK" RELATED Gene-based [UniProtKB:P43403] synonym: "ZAP70" RELATED Gene-based [UniProtKB:P43403] synonym: "hZAP70" EXACT PRO-short-label [PRO:DNx] synonym: "Syk-related tyrosine kinase (human)" EXACT [UniProtKB:P43403] synonym: "70 kDa zeta-chain associated protein (human)" EXACT [UniProtKB:P43403] xref: Reactome:R-HSA-202397 "PR:P43403 located_in GO:0005829" xref: DTO:03100572 xref: UniProtKB:P43403 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003064 ! tyrosine-protein kinase ZAP-70 relationship: has_gene_template HGNC:12858 ! ZAP70 (human) [Term] id: PR:P43403-2 name: tyrosine-protein kinase ZAP-70 isoform 2 (human) def: "A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hZAP70/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "tyrosine-protein kinase ZAP-70 isoform TZK (human)" EXACT [UniProtKB:P43403] xref: UniProtKB:P43403-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039469 ! tyrosine-protein kinase ZAP-70 isoform 2 [Term] id: PR:000003064 name: tyrosine-protein kinase ZAP-70 def: "A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human ZAP70 gene or a 1:1 ortholog thereof." [PRO:CL] comment: Category=gene. synonym: "SRK" RELATED Gene-based [] synonym: "ZAP70" EXACT PRO-short-label [PRO:DNx] synonym: "Zap-70" RELATED Gene-based [] synonym: "Syk-related tyrosine kinase" EXACT [] synonym: "70 kDa zeta-associated protein" EXACT [] synonym: "70 kDa zeta-chain associated protein" EXACT [] xref: IUPHARobj:2285 is_a: PR:000003063 ! SYK/ZAP-70 family tyrosine-protein kinase [Term] id: PR:000049722 name: tyrosine-protein kinase ZAP-70 phosphorylated 2 (human) def: "A tyrosine-protein kinase ZAP-70 (human) that has been post-translationally modified to include phosphotyrosine at positions 315 and 493 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-315/Tyr-493, MOD:00048." [PRO:DNx, Reactome:R-HSA-202252] comment: Category=organism-modification. synonym: "hZAP70/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P43403-1, Tyr-315/Tyr-493, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-202252 "PR:000049722 located_in GO:0005829" is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049723 name: tyrosine-protein kinase ZAP-70 phosphorylated 3 (human) def: "A tyrosine-protein kinase ZAP-70 (human) that has been post-translationally modified to include phosphotyrosine at position 493 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-493, MOD:00048." [PRO:DNx, Reactome:R-HSA-202368] comment: Category=organism-modification. synonym: "hZAP70/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P43403-1, Tyr-493, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-202368 "PR:000049723 located_in GO:0005829" is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P43403-1 name: tyrosine-protein kinase ZAP-70 isoform 1 (human) def: "A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hZAP70/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P43403-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003066 ! tyrosine-protein kinase ZAP-70 isoform 1 [Term] id: PR:000045788 name: tyrosine-protein kinase ZAP-70 phosphorylated 1 (human) def: "A tyrosine-protein kinase ZAP-70 (human) that has been phosphorylated at the position equivalent to Tyr-319 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-319, MOD:00048." [PMID:10202147, PMID:10318843, PMID:15292262, iPTMnet:P43403] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10202147, PMID:10318843, PMID:15292262). Status=unreviewed. synonym: "hZAP70/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P43403-1, Tyr-319, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000036629 name: tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human) def: "A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 in human." [PMID:9269777, PRO:CL] comment: Category=organism-modification. synonym: "hZAP70/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003068 ! tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine