[Term]
id: PR:P43404
name: tyrosine-protein kinase ZAP-70 (mouse)
def: "A tyrosine-protein kinase ZAP-70 that is encoded in the genome of mouse." [OMA:P43404, PRO:DNx]
comment: Category=organism-gene.
synonym: "Srk" RELATED Gene-based [UniProtKB:P43404]
synonym: "Zap70" RELATED Gene-based [UniProtKB:P43404]
synonym: "Zap-70" RELATED Gene-based [UniProtKB:P43404]
synonym: "mZAP70" EXACT PRO-short-label [PRO:DNx]
synonym: "Syk-related tyrosine kinase (mouse)" EXACT [UniProtKB:P43404]
synonym: "70 kDa zeta-chain associated protein (mouse)" EXACT [UniProtKB:P43404]
xref: UniProtKB:P43404
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003064 ! tyrosine-protein kinase ZAP-70
relationship: has_gene_template MGI:99613 ! Zap70 (mouse)

[Term]
id: PR:P43403-3
name: tyrosine-protein kinase ZAP-70 isoform h3 (human)
def: "A tyrosine-protein kinase ZAP-70 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-3." [PRO:DNx, UniProtKB:P43403]
comment: Category=organism-sequence.
synonym: "hZAP70/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43403-3
is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P43404-2
name: tyrosine-protein kinase ZAP-70 isoform 2 (mouse)
def: "A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mZAP70/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase ZAP-70 isoform TZK (mouse)" EXACT [UniProtKB:P43404]
xref: UniProtKB:P43404-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039469 ! tyrosine-protein kinase ZAP-70 isoform 2

[Term]
id: PR:P43403-2
name: tyrosine-protein kinase ZAP-70 isoform 2 (human)
def: "A tyrosine-protein kinase ZAP-70 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hZAP70/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase ZAP-70 isoform TZK (human)" EXACT [UniProtKB:P43403]
xref: UniProtKB:P43403-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039469 ! tyrosine-protein kinase ZAP-70 isoform 2

[Term]
id: PR:000039469
name: tyrosine-protein kinase ZAP-70 isoform 2
def: "A tyrosine-protein kinase ZAP-70 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "ZAP70/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003064 ! tyrosine-protein kinase ZAP-70

[Term]
id: PR:000003067
name: tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form
def: "A tyrosine-protein kinase ZAP-70 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "ZAP70/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003066 ! tyrosine-protein kinase ZAP-70 isoform 1

[Term]
id: PR:000003066
name: tyrosine-protein kinase ZAP-70 isoform 1
def: "A tyrosine-protein kinase ZAP-70 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43403-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "ZAP70/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003064 ! tyrosine-protein kinase ZAP-70

[Term]
id: PR:000003064
name: tyrosine-protein kinase ZAP-70
def: "A SYK/ZAP-70 family tyrosine-protein kinase that is a translation product of the human ZAP70 gene or a 1:1 ortholog thereof." [PRO:CL]
comment: Category=gene.
synonym: "SRK" RELATED Gene-based []
synonym: "ZAP70" EXACT PRO-short-label [PRO:DNx]
synonym: "Zap-70" RELATED Gene-based []
synonym: "Syk-related tyrosine kinase" EXACT []
synonym: "70 kDa zeta-associated protein" EXACT []
synonym: "70 kDa zeta-chain associated protein" EXACT []
xref: IUPHARobj:2285
is_a: PR:000003063 ! SYK/ZAP-70 family tyrosine-protein kinase

[Term]
id: PR:000049722
name: tyrosine-protein kinase ZAP-70 phosphorylated 2 (human)
def: "A tyrosine-protein kinase ZAP-70 (human) that has been post-translationally modified to include phosphotyrosine at positions 315 and 493 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-315/Tyr-493, MOD:00048." [PRO:DNx, Reactome:R-HSA-202252]
comment: Category=organism-modification.
synonym: "hZAP70/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43403-1, Tyr-315/Tyr-493, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202252 "PR:000049722 located_in GO:0005829"
is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049723
name: tyrosine-protein kinase ZAP-70 phosphorylated 3 (human)
def: "A tyrosine-protein kinase ZAP-70 (human) that has been post-translationally modified to include phosphotyrosine at position 493 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-493, MOD:00048." [PRO:DNx, Reactome:R-HSA-202368]
comment: Category=organism-modification.
synonym: "hZAP70/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43403-1, Tyr-493, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202368 "PR:000049723 located_in GO:0005829"
is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P43403-1
name: tyrosine-protein kinase ZAP-70 isoform 1 (human)
def: "A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hZAP70/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43403-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003066 ! tyrosine-protein kinase ZAP-70 isoform 1

[Term]
id: PR:P43404-1
name: tyrosine-protein kinase ZAP-70 isoform 1 (mouse)
def: "A tyrosine-protein kinase ZAP-70 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mZAP70/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43404-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003066 ! tyrosine-protein kinase ZAP-70 isoform 1

[Term]
id: PR:000045788
name: tyrosine-protein kinase ZAP-70 phosphorylated 1 (human)
def: "A tyrosine-protein kinase ZAP-70 (human) that has been phosphorylated at the position equivalent to Tyr-319 of the amino acid sequence represented by UniProtKB:P43403-1. Example: UniProtKB:P43403-1, Tyr-319, MOD:00048." [PMID:10202147, PMID:10318843, PMID:15292262, iPTMnet:P43403]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10202147, PMID:10318843, PMID:15292262). Status=unreviewed.
synonym: "hZAP70/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43403-1, Tyr-319, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P43403 ! tyrosine-protein kinase ZAP-70 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003068
name: tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1
def: "A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form in which the phosphorylation occurs on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck, following TCR engagement. Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. It has been shown that Tyr-319 in the human sequence is required for the positive regulation of ZAP-70 function." [PMID:10037717, PRO:CL]
comment: Category=modification.
synonym: "ZAP-70 activated" EXACT []
synonym: "ZAP-70 active form" EXACT []
synonym: "ZAP70/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003067 ! tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000036629
name: tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human)
def: "A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 in human." [PMID:9269777, PRO:CL]
comment: Category=organism-modification.
synonym: "hZAP70/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003068 ! tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P43404-3
name: tyrosine-protein kinase ZAP-70 isoform m3 (mouse)
def: "A tyrosine-protein kinase ZAP-70 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43404-3." [PRO:DNx, UniProtKB:P43404]
comment: Category=organism-sequence.
synonym: "mZAP70/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase ZAP-70 isoform TZK-2 (mouse)" EXACT [UniProtKB:P43404]
xref: UniProtKB:P43404-3
is_a: PR:P43404 ! tyrosine-protein kinase ZAP-70 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:A0A0R4J8U1
name: tyrosine-protein kinase (rat)
def: "A tyrosine-protein kinase ZAP-70 that is encoded in the genome of rat." [PRO:CL]
comment: Category=organism-gene.
synonym: "rZAP70" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:A0A0R4J8U1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003064 ! tyrosine-protein kinase ZAP-70
relationship: has_gene_template RGD:3983 ! Zap70 (rat)

[Term]
id: PR:P43403
name: tyrosine-protein kinase ZAP-70 (human)
def: "A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human." [PRO:CL, UniProtKB:P43403]
comment: Category=organism-gene.
synonym: "SRK" RELATED Gene-based [UniProtKB:P43403]
synonym: "ZAP70" RELATED Gene-based [UniProtKB:P43403]
synonym: "hZAP70" EXACT PRO-short-label [PRO:DNx]
synonym: "Syk-related tyrosine kinase (human)" EXACT [UniProtKB:P43403]
synonym: "70 kDa zeta-chain associated protein (human)" EXACT [UniProtKB:P43403]
xref: Reactome:R-HSA-202397 "PR:P43403 located_in GO:0005829"
xref: DTO:03100572
xref: UniProtKB:P43403
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003064 ! tyrosine-protein kinase ZAP-70
relationship: has_gene_template HGNC:12858 ! ZAP70 (human)