[Term]
id: PR:Q14289
name: protein-tyrosine kinase 2-beta (human)
def: "A focal adhesion kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q14289]
comment: Category=organism-gene.
synonym: "FAK2" RELATED Gene-based [UniProtKB:Q14289]
synonym: "PYK2" RELATED Gene-based [UniProtKB:Q14289]
synonym: "PTK2B" RELATED Gene-based [UniProtKB:Q14289]
synonym: "RAFTK" RELATED Gene-based [UniProtKB:Q14289]
synonym: "hPTK2B" EXACT PRO-short-label [PRO:DNx]
synonym: "CAKB (human)" EXACT [UniProtKB:Q14289]
synonym: "CADTK (human)" EXACT [UniProtKB:Q14289]
synonym: "FADK 2 (human)" EXACT [UniProtKB:Q14289]
synonym: "CAK-beta (human)" EXACT [UniProtKB:Q14289]
synonym: "focal adhesion kinase 2 (human)" EXACT [UniProtKB:Q14289]
synonym: "cell adhesion kinase beta (human)" EXACT [UniProtKB:Q14289]
synonym: "proline-rich tyrosine kinase 2 (human)" EXACT [UniProtKB:Q14289]
synonym: "calcium-dependent tyrosine kinase (human)" EXACT [UniProtKB:Q14289]
synonym: "related adhesion focal tyrosine kinase (human)" EXACT [UniProtKB:Q14289]
synonym: "calcium-regulated non-receptor proline-rich tyrosine kinase (human)" EXACT [UniProtKB:Q14289]
xref: Reactome:R-HSA-390932 "PR:Q14289 located_in GO:0005829"
xref: DTO:03100145
xref: UniProtKB:Q14289
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003032 ! focal adhesion kinase 2
relationship: has_gene_template HGNC:9612 ! PTK2B (human)

[Term]
id: PR:000003032
name: focal adhesion kinase 2
def: "A focal adhesion kinase that is a translation product of the human PTK2B gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "CAKB" EXACT []
synonym: "FAK2" RELATED Gene-based []
synonym: "PYK2" RELATED Gene-based []
synonym: "CADTK" EXACT []
synonym: "PTK2B" EXACT PRO-short-label [PRO:DNx]
synonym: "RAFTK" RELATED Gene-based []
synonym: "FADK 2" EXACT []
synonym: "CAK-beta" EXACT []
synonym: "cell adhesion kinase beta" EXACT []
synonym: "proline-rich tyrosine kinase 2" EXACT []
synonym: "calcium-dependent tyrosine kinase" EXACT []
synonym: "related adhesion focal tyrosine kinase" EXACT []
synonym: "calcium-regulated non-receptor proline-rich tyrosine kinase" EXACT []
xref: IUPHARobj:2181
is_a: PR:000003030 ! focal adhesion kinase

[Term]
id: PR:000036642
name: focal adhesion kinase 2 isoform 1 phosphorylated 1 (human)
def: "A focal adhesion kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]
comment: Category=organism-modification.
synonym: "hPTK2B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003242 ! focal adhesion kinase 2 isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q9QVP9
name: protein-tyrosine kinase 2-beta (mouse)
def: "A focal adhesion kinase 2 that is encoded in the genome of mouse." [OMA:Q9QVP9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fak2" RELATED Gene-based [UniProtKB:Q9QVP9]
synonym: "Pyk2" RELATED Gene-based [UniProtKB:Q9QVP9]
synonym: "Ptk2b" RELATED Gene-based [UniProtKB:Q9QVP9]
synonym: "Raftk" RELATED Gene-based [UniProtKB:Q9QVP9]
synonym: "mPTK2B" EXACT PRO-short-label [PRO:DNx]
synonym: "CAKB (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "CADTK (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "RAFTK (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "FADK 2 (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "CAK-beta (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "focal adhesion kinase 2 (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "cell adhesion kinase beta (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "proline-rich tyrosine kinase 2 (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "calcium-dependent tyrosine kinase (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "related adhesion focal tyrosine kinase (mouse)" EXACT [UniProtKB:Q9QVP9]
synonym: "calcium-regulated non-receptor proline-rich tyrosine kinase (mouse)" EXACT [UniProtKB:Q9QVP9]
xref: UniProtKB:Q9QVP9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003032 ! focal adhesion kinase 2
relationship: has_gene_template MGI:104908 ! Ptk2b (mouse)

[Term]
id: PR:000040522
name: focal adhesion kinase 2 isoform 2
def: "A focal adhesion kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14289-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PTK2B/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003032 ! focal adhesion kinase 2

[Term]
id: PR:000048954
name: protein-tyrosine kinase 2-beta phosphotyrosine form (human)
def: "A protein-tyrosine kinase 2-beta (human) that includes at least one phosphorylated tyrosine. UniProtKB:Q14289, MOD:00048." [PRO:DNx, Reactome:R-HSA-508515]
comment: Category=organism-modification.
synonym: "hPTK2B/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14289, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-508515 "PR:000048954 located_in GO:0005829"
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:Q14289 ! protein-tyrosine kinase 2-beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048953
name: protein-tyrosine kinase 2-beta phosphorylated 2 (human)
def: "A protein-tyrosine kinase 2-beta (human) that has been post-translationally modified to include phosphotyrosine at position 402 of the amino acid sequence represented by UniProtKB:Q14289. UniProtKB:Q14289, Tyr-402, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218721]
comment: Category=organism-modification.
synonym: "hPTK2B/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14289, Tyr-402, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218721 "PR:000048953 located_in GO:0005829"
is_a: PR:Q14289 ! protein-tyrosine kinase 2-beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003239
name: focal adhesion kinase 2 isoform 1
def: "A focal adhesion kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14289-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "PTK2B/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003032 ! focal adhesion kinase 2

[Term]
id: PR:P70600
name: protein-tyrosine kinase 2-beta (rat)
def: "A focal adhesion kinase 2 that is encoded in the genome of rat." [OMA:P70600, PANTHER:PTHR24418:SF277, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fak2" RELATED Gene-based [UniProtKB:P70600]
synonym: "Pyk2" RELATED Gene-based [UniProtKB:P70600]
synonym: "Ptk2b" RELATED Gene-based [UniProtKB:P70600]
synonym: "rPTK2B" EXACT PRO-short-label [PRO:DNx]
synonym: "CAKB (rat)" EXACT [UniProtKB:P70600]
synonym: "CADTK (rat)" EXACT [UniProtKB:P70600]
synonym: "FADK 2 (rat)" EXACT [UniProtKB:P70600]
synonym: "CAK-beta (rat)" EXACT [UniProtKB:P70600]
synonym: "focal adhesion kinase 2 (rat)" EXACT [UniProtKB:P70600]
synonym: "cell adhesion kinase beta (rat)" EXACT [UniProtKB:P70600]
synonym: "proline-rich tyrosine kinase 2 (rat)" EXACT [UniProtKB:P70600]
synonym: "calcium-dependent tyrosine kinase (rat)" EXACT [UniProtKB:P70600]
synonym: "calcium-regulated non-receptor proline-rich tyrosine kinase (rat)" EXACT [UniProtKB:P70600]
xref: UniProtKB:P70600
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003032 ! focal adhesion kinase 2
relationship: has_gene_template RGD:628758 ! Ptk2b (rat)

[Term]
id: PR:000003242
name: focal adhesion kinase 2 isoform 1 phosphorylated 1
def: "A focal adhesion kinase 2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residues that yield the active kinase. Example: UniProtKB:Q14289-1, Tyr-402/Tyr-579/Tyr-580/Tyr-881, MOD:00048." [PMID:11698270, PRO:CL]
comment: Category=modification.
synonym: "pyk2 active form" EXACT []
synonym: "PTK2B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003241 ! focal adhesion kinase 2 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000003241
name: focal adhesion kinase 2 isoform 1 phosphorylated form
def: "A focal adhesion kinase 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "PTK2B/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003239 ! focal adhesion kinase 2 isoform 1

[Term]
id: PR:P70600-2
name: protein-tyrosine kinase 2-beta isoform r2 (rat)
def: "A protein-tyrosine kinase 2-beta (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70600-2." [PRO:DNx, UniProtKB:P70600]
comment: Category=organism-sequence.
synonym: "rPTK2B/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "protein-tyrosine kinase 2-beta isoform PRNK (rat)" EXACT [UniProtKB:P70600]
xref: UniProtKB:P70600-2
is_a: PR:P70600 ! protein-tyrosine kinase 2-beta (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q14289-1
name: protein-tyrosine kinase 2-beta isoform 1 (human)
def: "A focal adhesion kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hPTK2B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14289-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003239 ! focal adhesion kinase 2 isoform 1

[Term]
id: PR:P70600-1
name: protein-tyrosine kinase 2-beta isoform r1 (rat)
def: "A protein-tyrosine kinase 2-beta (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70600-1." [PRO:DNx, UniProtKB:P70600]
comment: Category=organism-sequence.
synonym: "rPTK2B/iso:r1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70600-1
is_a: PR:P70600 ! protein-tyrosine kinase 2-beta (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q14289-2
name: protein-tyrosine kinase 2-beta isoform 2 (human)
def: "A focal adhesion kinase 2 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPTK2B/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "protein-tyrosine kinase 2-beta isoform PYK2H (human)" EXACT [UniProtKB:Q14289]
xref: UniProtKB:Q14289-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040522 ! focal adhesion kinase 2 isoform 2

[Term]
id: PR:P70600-3
name: protein-tyrosine kinase 2-beta isoform 3 (rat)
def: "A focal adhesion kinase 2 isoform 2 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPTK2B/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "protein-tyrosine kinase 2-beta isoform PYK2s (rat)" EXACT [UniProtKB:P70600]
xref: UniProtKB:P70600-3
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000040522 ! focal adhesion kinase 2 isoform 2