[Term]
id: PR:000048949
name: focal adhesion kinase 1, initiator methionine removed form (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed. UniProtKB:Q05397, 2-1052." [PRO:DNx, Reactome:R-HSA-201621]
comment: Category=organism-modification.
synonym: "PRO_0000088077" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPTK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201621 "PR:000048949 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003031
name: focal adhesion kinase 1
def: "A focal adhesion kinase that is a translation product of the human PTK2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "FAK" RELATED Gene-based []
synonym: "FAK1" RELATED Gene-based []
synonym: "FRNK" EXACT []
synonym: "Fadk" RELATED Gene-based []
synonym: "PTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "FADK 1" EXACT []
synonym: "p125FAK" EXACT []
synonym: "Kiaa4203" RELATED Gene-based []
synonym: "pp125FAK" EXACT []
synonym: "protein-tyrosine kinase 2" EXACT []
synonym: "focal adhesion kinase-related nonkinase" EXACT []
xref: IUPHARobj:2180
is_a: PR:000003030 ! focal adhesion kinase

[Term]
id: PR:Q05397-3
name: focal adhesion kinase 1 isoform h3 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-3." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-3
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-2
name: focal adhesion kinase 1 isoform h2 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-2." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-2
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-1
name: focal adhesion kinase 1 isoform 1 (human)
def: "A focal adhesion kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPTK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026197 ! focal adhesion kinase 1 isoform 1

[Term]
id: PR:000048952
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 5 (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 397, 576, 577, 861 and 925, and phosphoserine at position 732 of the amino acid sequence represented by UniProtKB:Q05397. UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046." [PRO:DNx, Reactome:R-HSA-5229006]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5229006 "PR:000048952 located_in GO:0005829"
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q05397-6
name: focal adhesion kinase 1 isoform h6 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-6." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "focal adhesion kinase 1 isoform FRNK (human)" EXACT [UniProtKB:Q05397]
xref: UniProtKB:Q05397-6
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048950
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 3 (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 397, 407, 576, 577, 861 and 925, and phosphoserine at position 732 of the amino acid sequence represented by UniProtKB:Q05397. UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218694]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218694 "PR:000048950 located_in GO:0005829"
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048951
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 4 (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 397, 576, 577, 861 and 925 of the amino acid sequence represented by UniProtKB:Q05397. UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218711]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218711 "PR:000048951 located_in GO:0005829"
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026219
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 1 (human)
def: "A focal adhesion kinase 1, initiator methionine removed phosphorylated 1 in human. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397, MOD:00048." [PRO:CNx, Reactome:R-HSA-354068]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397, MOD:00048" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397-1, 2-1052, Tyr-397, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-354068 "PR:000026219 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026199 ! focal adhesion kinase 1, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000026218
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 2 (human)
def: "A focal adhesion kinase 1, initiator methionine removed phosphorylated 2 in human. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048." [PRO:CNA, PRO:DAN, Reactome:R-HSA-354128]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397-1, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" NARROW PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-354128 "PR:000026218 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026200 ! focal adhesion kinase 1, initiator methionine removed phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q05397
name: focal adhesion kinase 1 (human)
def: "A focal adhesion kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q05397]
comment: Category=organism-gene.
synonym: "FAK" RELATED Gene-based [UniProtKB:Q05397]
synonym: "FAK1" RELATED Gene-based [UniProtKB:Q05397]
synonym: "PTK2" RELATED Gene-based [UniProtKB:Q05397]
synonym: "hPTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "FRNK (human)" EXACT [UniProtKB:Q05397]
synonym: "FADK 1 (human)" EXACT [UniProtKB:Q05397]
synonym: "PPP1R71 (human)" EXACT [UniProtKB:Q05397]
synonym: "p125FAK (human)" EXACT [UniProtKB:Q05397]
synonym: "pp125FAK (human)" EXACT [UniProtKB:Q05397]
synonym: "protein-tyrosine kinase 2 (human)" EXACT [UniProtKB:Q05397]
synonym: "focal adhesion kinase-related nonkinase (human)" EXACT [UniProtKB:Q05397]
synonym: "protein phosphatase 1 regulatory subunit 71 (human)" EXACT [UniProtKB:Q05397]
xref: DTO:03100144
xref: UniProtKB:Q05397
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003031 ! focal adhesion kinase 1
relationship: has_gene_template HGNC:9611 ! PTK2 (human)

[Term]
id: PR:Q05397-5
name: focal adhesion kinase 1 isoform h5 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-5." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-5
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-4
name: focal adhesion kinase 1 isoform h4 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-4." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-4
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-7
name: focal adhesion kinase 1 isoform h7 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-7." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-7
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens