[Term]
id: PR:P34152-7
name: focal adhesion kinase 1 isoform m7 (mouse)
def: "A focal adhesion kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-7." [PRO:DNx, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:m7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-7
is_a: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O35346
name: focal adhesion kinase 1 (rat)
def: "A focal adhesion kinase 1 that is encoded in the genome of rat." [OMA:O35346, PANTHER:PTHR24418:SF277, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fak" RELATED Gene-based [UniProtKB:O35346]
synonym: "Fak1" RELATED Gene-based [UniProtKB:O35346]
synonym: "Ptk2" RELATED Gene-based [UniProtKB:O35346]
synonym: "rPTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "FRNK (rat)" EXACT [UniProtKB:O35346]
synonym: "FADK 1 (rat)" EXACT [UniProtKB:O35346]
synonym: "p125FAK (rat)" EXACT [UniProtKB:O35346]
synonym: "pp125FAK (rat)" EXACT [UniProtKB:O35346]
synonym: "protein-tyrosine kinase 2 (rat)" EXACT [UniProtKB:O35346]
synonym: "focal adhesion kinase-related nonkinase (rat)" EXACT [UniProtKB:O35346]
xref: UniProtKB:O35346
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003031 ! focal adhesion kinase 1
relationship: has_gene_template RGD:3443 ! Ptk2 (rat)

[Term]
id: PR:P34152-5
name: focal adhesion kinase 1 isoform m5 (mouse)
def: "A focal adhesion kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-5." [PRO:DNx, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:m5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-5
is_a: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P34152-4
name: focal adhesion kinase 1 isoform 4 (mouse)
def: "A focal adhesion kinase 1 isoform 4 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-4
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039313 ! focal adhesion kinase 1 isoform 4

[Term]
id: PR:P34152-3
name: focal adhesion kinase 1 isoform 1 (mouse)
def: "A focal adhesion kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026197 ! focal adhesion kinase 1 isoform 1

[Term]
id: PR:P34152-2
name: focal adhesion kinase 1 isoform m2 (mouse)
def: "A focal adhesion kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-2." [PRO:DNx, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-2
is_a: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P34152-6
name: focal adhesion kinase 1 isoform m6 (mouse)
def: "A focal adhesion kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-6." [PRO:DNx, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:m6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-6
is_a: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000048952
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 5 (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 397, 576, 577, 861 and 925, and phosphoserine at position 732 of the amino acid sequence represented by UniProtKB:Q05397. UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046." [PRO:DNx, Reactome:R-HSA-5229006]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5229006 "PR:000048952 located_in GO:0005829"
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048950
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 3 (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 397, 407, 576, 577, 861 and 925, and phosphoserine at position 732 of the amino acid sequence represented by UniProtKB:Q05397. UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218694]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048|Ser-732, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218694 "PR:000048950 located_in GO:0005829"
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000048951
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 4 (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 397, 576, 577, 861 and 925 of the amino acid sequence represented by UniProtKB:Q05397. UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218711]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052, Tyr-397/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218711 "PR:000048951 located_in GO:0005829"
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026197
name: focal adhesion kinase 1 isoform 1
def: "A focal adhesion kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-1 or a 1:1 ortholog thereof." [PRO:CNx]
comment: Category=sequence.
synonym: "PTK2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003031 ! focal adhesion kinase 1

[Term]
id: PR:000049948
name: focal adhesion kinase 1 isoform 1 phosphorylated 2 (rat)
def: "A focal adhesion kinase 1 isoform 1 (rat) that has been phosphorylated at positions equivalent to Tyr-576 and Tyr-577. UniProtKB:O35346-1, Tyr-576/Tyr-577, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rPTK2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35346-1, Tyr-576/Tyr-577, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35346-1 ! focal adhesion kinase 1 isoform 1 (rat)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000049949
name: focal adhesion kinase 1 isoform 1 unphosphorylated 2 (rat)
def: "A focal adhesion kinase 1 isoform 1 (rat) that is unphosphorylated at positions equivalent to Tyr-576 and Tyr-577. UniProtKB:O35346-1, Tyr-576/Tyr-577, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rPTK2/iso:1/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35346-1, Tyr-576/Tyr-577, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35346-1 ! focal adhesion kinase 1 isoform 1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000026219
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 1 (human)
def: "A focal adhesion kinase 1, initiator methionine removed phosphorylated 1 in human. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397, MOD:00048." [PRO:CNx, Reactome:R-HSA-354068]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397, MOD:00048" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397-1, 2-1052, Tyr-397, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-354068 "PR:000026219 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026199 ! focal adhesion kinase 1, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000026218
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 2 (human)
def: "A focal adhesion kinase 1, initiator methionine removed phosphorylated 2 in human. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048." [PRO:CNA, PRO:DAN, Reactome:R-HSA-354128]
comment: Category=organism-modification.
synonym: "hPTK2/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088077, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q05397-1, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048" NARROW PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-354128 "PR:000026218 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026200 ! focal adhesion kinase 1, initiator methionine removed phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:Q05397
name: focal adhesion kinase 1 (human)
def: "A focal adhesion kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q05397]
comment: Category=organism-gene.
synonym: "FAK" RELATED Gene-based [UniProtKB:Q05397]
synonym: "FAK1" RELATED Gene-based [UniProtKB:Q05397]
synonym: "PTK2" RELATED Gene-based [UniProtKB:Q05397]
synonym: "hPTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "FRNK (human)" EXACT [UniProtKB:Q05397]
synonym: "FADK 1 (human)" EXACT [UniProtKB:Q05397]
synonym: "PPP1R71 (human)" EXACT [UniProtKB:Q05397]
synonym: "p125FAK (human)" EXACT [UniProtKB:Q05397]
synonym: "pp125FAK (human)" EXACT [UniProtKB:Q05397]
synonym: "protein-tyrosine kinase 2 (human)" EXACT [UniProtKB:Q05397]
synonym: "focal adhesion kinase-related nonkinase (human)" EXACT [UniProtKB:Q05397]
synonym: "protein phosphatase 1 regulatory subunit 71 (human)" EXACT [UniProtKB:Q05397]
xref: DTO:03100144
xref: UniProtKB:Q05397
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003031 ! focal adhesion kinase 1
relationship: has_gene_template HGNC:9611 ! PTK2 (human)

[Term]
id: PR:000049943
name: focal adhesion kinase 1, initiator methionine removed form (mouse)
def: "A focal adhesion kinase 1 (mouse) that has had the initiator methionine removed. UniProtKB:P34152, 2-1052." [PRO:CNA, UniProtKB:P34152]
comment: Category=organism-modification.
synonym: "mPTK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P34152, 2-1052" EXACT PRO-proteoform-std [PRO:DAN]
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049946
name: focal adhesion kinase 1 isoform 1 phosphorylated 1 (rat)
def: "A focal adhesion kinase 1 isoform 1 (rat) that has been phosphorylated at the position equivalent to Tyr-397. UniProtKB:O35346-1, Tyr-397, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rPTK2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35346-1, Tyr-397, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35346-1 ! focal adhesion kinase 1 isoform 1 (rat)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000049947
name: focal adhesion kinase 1 isoform 1 unphosphorylated 1 (rat)
def: "A focal adhesion kinase 1 isoform 1 (rat) that is unphosphorylated at the position equivalent to Tyr-397. UniProtKB:O35346-1, Tyr-397, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rPTK2/iso:1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35346-1, Tyr-397, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35346-1 ! focal adhesion kinase 1 isoform 1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000049944
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 1 (mouse)
def: "A focal adhesion kinase 1, initiator methionine removed phosphorylated 1 in mouse. UniProtKB:P34152, 2-1052, Tyr-397, MOD:00048." [PMID:27994061, PRO:DAN, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061 for phosphorylation). Evidence=(ECO:0000205, based on UniProtKB:P34152 for methionine removal).
synonym: "mPTK2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P34152, 2-1052, Tyr-397, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026199 ! focal adhesion kinase 1, initiator methionine removed phosphorylated 1
disjoint_from: PR:P34152-8 ! focal adhesion kinase 1 isoform m8 (mouse)
disjoint_from: PR:P34152-9 ! focal adhesion kinase 1 isoform m9 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000049945
name: focal adhesion kinase 1, initiator methionine removed unphosphorylated 1 (mouse)
def: "A focal adhesion kinase 1, initiator methionine removed form (mouse) that is unphosphorylated at the position equivalent to Tyr-397 of the amino acid sequence represented by UniProtKB:Q05397-1. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000205, based on UniProtKB:P34152 for methionine removal).
synonym: "mPTK2/InitMet-/UnPhos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q05397-1, 2-1052, Tyr-397, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000049943 ! focal adhesion kinase 1, initiator methionine removed form (mouse)
disjoint_from: PR:P34152-8 ! focal adhesion kinase 1 isoform m8 (mouse)
disjoint_from: PR:P34152-9 ! focal adhesion kinase 1 isoform m9 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000026628
name: focal adhesion kinase 1 isoform 1, initiator methionine removed form
def: "A focal adhesion kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PTK2/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:000026197 ! focal adhesion kinase 1 isoform 1

[Term]
id: PR:000003031
name: focal adhesion kinase 1
def: "A focal adhesion kinase that is a translation product of the human PTK2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "FAK" RELATED Gene-based []
synonym: "FAK1" RELATED Gene-based []
synonym: "FRNK" EXACT []
synonym: "Fadk" RELATED Gene-based []
synonym: "PTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "FADK 1" EXACT []
synonym: "p125FAK" EXACT []
synonym: "Kiaa4203" RELATED Gene-based []
synonym: "pp125FAK" EXACT []
synonym: "protein-tyrosine kinase 2" EXACT []
synonym: "focal adhesion kinase-related nonkinase" EXACT []
xref: IUPHARobj:2180
is_a: PR:000003030 ! focal adhesion kinase

[Term]
id: PR:P34152-9
name: focal adhesion kinase 1 isoform m9 (mouse)
def: "A focal adhesion kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-9." [PRO:DNx, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:m9" EXACT PRO-short-label [PRO:DNx]
synonym: "focal adhesion kinase 1 isoform FRNK (mouse)" EXACT [UniProtKB:P34152]
xref: UniProtKB:P34152-9
is_a: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000039313
name: focal adhesion kinase 1 isoform 4
def: "A focal adhesion kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-4 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PTK2/iso:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003031 ! focal adhesion kinase 1

[Term]
id: PR:Q05397-3
name: focal adhesion kinase 1 isoform h3 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-3." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-3
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-2
name: focal adhesion kinase 1 isoform h2 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-2." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-2
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-1
name: focal adhesion kinase 1 isoform 1 (human)
def: "A focal adhesion kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPTK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026197 ! focal adhesion kinase 1 isoform 1

[Term]
id: PR:Q05397-7
name: focal adhesion kinase 1 isoform h7 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-7." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-7
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-6
name: focal adhesion kinase 1 isoform h6 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-6." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "focal adhesion kinase 1 isoform FRNK (human)" EXACT [UniProtKB:Q05397]
xref: UniProtKB:Q05397-6
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-5
name: focal adhesion kinase 1 isoform h5 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-5." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-5
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05397-4
name: focal adhesion kinase 1 isoform h4 (human)
def: "A focal adhesion kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05397-4." [PRO:DNx, UniProtKB:Q05397]
comment: Category=organism-sequence.
synonym: "hPTK2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05397-4
is_a: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000018781
name: focal adhesion kinase 1, initiator methionine removed form
def: "A focal adhesion kinase 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PTK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003031 ! focal adhesion kinase 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026199
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 1
def: "A focal adhesion kinase 1, initiator methionine removed form that has been phosphorylated on a Tyr residue by autocatalysis. Example: UniProtKB:Q05397-1, Tyr-397, MOD:00048." [PRO:CNx, Reactome:R-HSA-354068]
comment: Category=modification.
synonym: "PTK2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000018781 ! focal adhesion kinase 1, initiator methionine removed form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000048949
name: focal adhesion kinase 1, initiator methionine removed form (human)
def: "A focal adhesion kinase 1 (human) that has had the initiator methionine removed. UniProtKB:Q05397, 2-1052." [PRO:DNx, Reactome:R-HSA-201621]
comment: Category=organism-modification.
synonym: "PRO_0000088077" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPTK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q05397, 2-1052" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201621 "PR:000048949 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q05397 ! focal adhesion kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049951
name: focal adhesion kinase 1 isoform 1 unphosphorylated 3 (rat)
def: "A focal adhesion kinase 1 isoform 1 (rat) that is unphosphorylated at the position equivalent to Tyr-928. UniProtKB:O35346-1, Tyr-928, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rPTK2/iso:1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35346-1, Tyr-928, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35346-1 ! focal adhesion kinase 1 isoform 1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000049950
name: focal adhesion kinase 1 isoform 1 phosphorylated 3 (rat)
def: "A focal adhesion kinase 1 isoform 1 (rat) that has been phosphorylated at the position equivalent to Tyr-928. UniProtKB:O35346-1, Tyr-928, MOD:00048." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "rPTK2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35346-1, Tyr-928, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35346-1 ! focal adhesion kinase 1 isoform 1 (rat)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P34152
name: focal adhesion kinase 1 (mouse)
def: "A focal adhesion kinase 1 that is encoded in the genome of mouse." [OMA:P34152, PRO:DNx]
comment: Category=organism-gene.
synonym: "Fak" RELATED Gene-based [UniProtKB:P34152]
synonym: "Fadk" RELATED Gene-based [UniProtKB:P34152]
synonym: "Fak1" RELATED Gene-based [UniProtKB:P34152]
synonym: "Ptk2" RELATED Gene-based [UniProtKB:P34152]
synonym: "mPTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "Kiaa4203" RELATED Gene-based [UniProtKB:P34152]
synonym: "FRNK (mouse)" EXACT [UniProtKB:P34152]
synonym: "FADK 1 (mouse)" EXACT [UniProtKB:P34152]
synonym: "p125FAK (mouse)" EXACT [UniProtKB:P34152]
synonym: "pp125FAK (mouse)" EXACT [UniProtKB:P34152]
synonym: "protein-tyrosine kinase 2 (mouse)" EXACT [UniProtKB:P34152]
synonym: "focal adhesion kinase-related nonkinase (mouse)" EXACT [UniProtKB:P34152]
xref: UniProtKB:P34152
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003031 ! focal adhesion kinase 1
relationship: has_gene_template MGI:95481 ! Ptk2 (mouse)

[Term]
id: PR:P34152-8
name: focal adhesion kinase 1 isoform m8 (mouse)
def: "A focal adhesion kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34152-8." [PRO:DNx, UniProtKB:P34152]
comment: Category=organism-sequence.
synonym: "mPTK2/iso:m8" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34152-8
is_a: PR:P34152 ! focal adhesion kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000026200
name: focal adhesion kinase 1, initiator methionine removed phosphorylated 2
def: "A focal adhesion kinase 1, initiator methionine removed form that has been phosphorylated on a Tyr residue by autocatalysis and further phosphorylated by SRC within the kinase doman activation loop and within the FADK1 C-terminal domain. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397/Tyr-407/Tyr-576/Tyr-577/Tyr-861/Tyr-925, MOD:00048." [PRO:CNA, PRO:DAN, Reactome:R-HSA-354128]
comment: Category=modification.
synonym: "PTK2/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000018781 ! focal adhesion kinase 1, initiator methionine removed form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:O35346-1
name: focal adhesion kinase 1 isoform 1 (rat)
def: "A focal adhesion kinase 1 isoform 4 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPTK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35346-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039313 ! focal adhesion kinase 1 isoform 4

[Term]
id: PR:O35346-2
name: focal adhesion kinase 1 isoform r2 (rat)
def: "A focal adhesion kinase 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35346-2." [PRO:DNx, UniProtKB:O35346]
comment: Category=organism-sequence.
synonym: "rPTK2/iso:r2" EXACT PRO-short-label [PRO:DNx]
synonym: "focal adhesion kinase 1 isoform FRNK (rat)" EXACT [UniProtKB:O35346]
xref: UniProtKB:O35346-2
is_a: PR:O35346 ! focal adhesion kinase 1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:Q00944
name: focal adhesion kinase 1 (chicken)
def: "A focal adhesion kinase 1 that is encoded in the genome of chicken." [OMA:Q00944, PANTHER:PTHR24418:SF277, PRO:DNx]
comment: Category=organism-gene.
synonym: "FAK" RELATED Gene-based [UniProtKB:Q00944]
synonym: "FAK1" RELATED Gene-based [UniProtKB:Q00944]
synonym: "PTK2" RELATED Gene-based [UniProtKB:Q00944]
synonym: "chick-PTK2" EXACT PRO-short-label [PRO:DNx]
synonym: "FRNK (chicken)" EXACT [UniProtKB:Q00944]
synonym: "FADK 1 (chicken)" EXACT [UniProtKB:Q00944]
synonym: "p125FAK (chicken)" EXACT [UniProtKB:Q00944]
synonym: "pp125FAK (chicken)" EXACT [UniProtKB:Q00944]
synonym: "p41/p43FRNK (chicken)" EXACT [UniProtKB:Q00944]
synonym: "protein-tyrosine kinase 2 (chicken)" EXACT [UniProtKB:Q00944]
synonym: "focal adhesion kinase-related nonkinase (chicken)" EXACT [UniProtKB:Q00944]
xref: UniProtKB:Q00944
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000003031 ! focal adhesion kinase 1
relationship: has_gene_template NCBIGene:396416 ! PTK2 (chicken)

[Term]
id: PR:Q00944-2
name: focal adhesion kinase 1 isoform 2 (chicken)
def: "A focal adhesion kinase 1 (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00944-2." [PRO:DNx, UniProtKB:Q00944]
comment: Category=organism-sequence.
synonym: "chick-PTK2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "focal adhesion kinase 1 isoform FRNK (chicken)" EXACT [UniProtKB:Q00944]
xref: UniProtKB:Q00944-2
is_a: PR:Q00944 ! focal adhesion kinase 1 (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:Q00944-1
name: focal adhesion kinase 1 isoform 1 (chicken)
def: "A focal adhesion kinase 1 (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00944-1." [PRO:DNx, UniProtKB:Q00944]
comment: Category=organism-sequence.
synonym: "chick-PTK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00944-1
is_a: PR:Q00944 ! focal adhesion kinase 1 (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus