[Term]
id: PR:O89110
name: caspase-8 (mouse)
def: "A caspase-8 that is encoded in the genome of mouse." [OMA:O89110, PRO:DNx]
comment: Category=organism-gene.
synonym: "Casp8" RELATED Gene-based [UniProtKB:O89110]
synonym: "mCASP8" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-8 (mouse)" EXACT [UniProtKB:O89110]
xref: UniProtKB:O89110
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002317 ! caspase-8
relationship: has_gene_template MGI:1261423 ! Casp8 (mouse)

[Term]
id: PR:000002420
name: caspase-8 isoform 9
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-9 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "8L" BROAD [PRO:DNx]
synonym: "CASP8/iso:9" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000045931
name: caspase-8 phosphorylated 1 (human)
def: "A caspase-8 (human) that has been phosphorylated at the position equivalent to Tyr-380 of the amino acid sequence represented by UniProtKB:Q14790-1. Example: UniProtKB:Q14790-1, Tyr-380, MOD:00048." [PMID:16619028, PMID:19851329, iPTMnet:Q14790]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16619028, PMID:19851329). Status=unreviewed.
synonym: "hCASP8/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14790-1, Tyr-380, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14790 ! caspase-8 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000002317
name: caspase-8
def: "A caspase-8-like protease that is a translation product of the human CASP8 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "CAP4" EXACT []
synonym: "MACH" EXACT []
synonym: "MCH5" RELATED Gene-based []
synonym: "CASP8" EXACT PRO-short-label [PRO:DNx]
synonym: "FLICE" EXACT []
synonym: "CASP-8" EXACT []
synonym: "FADD-like ICE" EXACT []
synonym: "apoptotic protease Mch-5" EXACT []
synonym: "apoptotic cysteine protease" EXACT []
synonym: "ICE-like apoptotic protease 5" EXACT []
synonym: "MORT1-associated ced-3 homolog" EXACT []
synonym: "FADD-homologous ICE/ced-3-like protease" EXACT []
xref: IUPHARobj:1624
xref: PIRSF:PIRSF500656
is_a: PR:000002197 ! caspase-8-like protease

[Term]
id: PR:000036063
name: caspase-8 isoform 1 cleaved 1 (human)
def: "A caspase-8 isoform 1 cleaved 1 in human. UniProtKB:Q14790-1, 217-374." [PMID:9184224, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000004629" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCASP8/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14790-1, 217-374" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "human caspase-8 subunit p18" EXACT []
xref: Reactome:R-HSA-351869 "PR:000036063 located_in GO:0005741"
xref: Reactome:R-HSA-75975 "PR:000036063 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000036062 ! caspase-8 isoform 1 cleaved 1

[Term]
id: PR:000036062
name: caspase-8 isoform 1 cleaved 1
def: "A caspase-8 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-8 subunit p18." [PRO:CNA]
comment: Category=modification.
synonym: "CASP8/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 subunit p18" RELATED []
is_a: PR:000002412 ! caspase-8 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000036065
name: caspase-8 isoform 1 cleaved 2 (human)
def: "A caspase-8 isoform 1 cleaved 2 in human. UniProtKB:Q14790-1, 385-479." [PMID:9184224, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000004631" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hCASP8/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14790-1, 385-479" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "human caspase-8 subunit p10" EXACT []
xref: Reactome:R-HSA-351828 "PR:000036065 located_in GO:0005741"
xref: Reactome:R-HSA-76158 "PR:000036065 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000036064 ! caspase-8 isoform 1 cleaved 2

[Term]
id: PR:000036064
name: caspase-8 isoform 1 cleaved 2
def: "A caspase-8 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-8 subunit p10." [PRO:CNA]
comment: Category=modification.
synonym: "CASP8/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 subunit p10" RELATED []
is_a: PR:000002412 ! caspase-8 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:Q14790
name: caspase-8 (human)
def: "A caspase-8 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "MCH5" RELATED Gene-based [UniProtKB:Q14790]
synonym: "CASP8" RELATED Gene-based [UniProtKB:Q14790]
synonym: "hCASP8" EXACT PRO-short-label [PRO:DNx]
synonym: "CAP4 (human)" EXACT [UniProtKB:Q14790]
synonym: "MACH (human)" EXACT [UniProtKB:Q14790]
synonym: "FLICE (human)" EXACT [UniProtKB:Q14790]
synonym: "CASP-8 (human)" EXACT [UniProtKB:Q14790]
synonym: "FADD-like ICE (human)" EXACT [UniProtKB:Q14790]
synonym: "apoptotic protease Mch-5 (human)" EXACT [UniProtKB:Q14790]
synonym: "apoptotic cysteine protease (human)" EXACT [UniProtKB:Q14790]
synonym: "ICE-like apoptotic protease 5 (human)" EXACT [UniProtKB:Q14790]
synonym: "MORT1-associated ced-3 homolog (human)" EXACT [UniProtKB:Q14790]
synonym: "FADD-homologous ICE/ced-3-like protease (human)" EXACT [UniProtKB:Q14790]
xref: Reactome:R-HSA-57031 "PR:Q14790 located_in GO:0005829"
xref: UniProtKB:Q14790
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002317 ! caspase-8
relationship: has_gene_template HGNC:1509 ! CASP8 (human)

[Term]
id: PR:000002419
name: caspase-8 isoform 8
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-8 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "CASP8/iso:8" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform beta-4" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002418
name: caspase-8 isoform 7
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-7 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "8L" EXACT []
synonym: "CASP8/iso:7" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform beta-3" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002415
name: caspase-8 isoform 4
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-4 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "CASP8/iso:4" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform alpha-4" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002414
name: caspase-8 isoform 3
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-3 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "CASP8/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform alpha-3" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002417
name: caspase-8 isoform 6
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-6 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "CASP8/iso:6" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform beta-2" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002416
name: caspase-8 isoform 5
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-5 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "CASP8/iso:5" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform beta-1" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002413
name: caspase-8 isoform 2
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-2 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "MCH5-beta" EXACT []
synonym: "CASP8/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform alpha-2" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000002412
name: caspase-8 isoform 1
def: "A caspase-8 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14790-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "CASP8/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform alpha-1" EXACT []
is_a: PR:000002317 ! caspase-8

[Term]
id: PR:000018768
name: caspase-8 proteolytic cleavage product
def: "A caspase-8 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "CASP8/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000002317 ! caspase-8

[Term]
id: PR:Q9JHX4
name: caspase-8 (rat)
def: "A caspase-8 that is encoded in the genome of rat." [OMA:Q9JHX4, PANTHER:PTHR10454:SF26, PRO:DNx]
comment: Category=organism-gene.
synonym: "Casp8" RELATED Gene-based [UniProtKB:Q9JHX4]
synonym: "rCASP8" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-8 (rat)" EXACT [UniProtKB:Q9JHX4]
xref: UniProtKB:Q9JHX4
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002317 ! caspase-8
relationship: has_gene_template RGD:620945 ! Casp8 (rat)

[Term]
id: PR:O89110-1
name: caspase-8 isoform 1 (mouse)
def: "A caspase-8 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mCASP8/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O89110-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002412 ! caspase-8 isoform 1

[Term]
id: PR:Q14790-2
name: caspase-8 isoform 2 (human)
def: "A caspase-8 isoform 2 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Alpha-2 (human)" EXACT [UniProtKB:Q14790]
synonym: "caspase-8 isoform MCH5-beta (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002413 ! caspase-8 isoform 2

[Term]
id: PR:Q14790-3
name: caspase-8 isoform 3 (human)
def: "A caspase-8 isoform 3 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Alpha-3 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002414 ! caspase-8 isoform 3

[Term]
id: PR:Q14790-1
name: caspase-8 isoform 1 (human)
def: "A caspase-8 isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Alpha-1 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002412 ! caspase-8 isoform 1

[Term]
id: PR:Q14790-6
name: caspase-8 isoform 6 (human)
def: "A caspase-8 isoform 6 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:6" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Beta-2 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002417 ! caspase-8 isoform 6

[Term]
id: PR:Q14790-7
name: caspase-8 isoform 7 (human)
def: "A caspase-8 isoform 7 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:7" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform 8L (human)" BROAD [UniProtKB:Q14790]
synonym: "caspase-8 isoform Beta-3 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002418 ! caspase-8 isoform 7

[Term]
id: PR:Q14790-4
name: caspase-8 isoform 4 (human)
def: "A caspase-8 isoform 4 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:4" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Alpha-4 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002415 ! caspase-8 isoform 4

[Term]
id: PR:Q14790-5
name: caspase-8 isoform 5 (human)
def: "A caspase-8 isoform 5 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:5" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Beta-1 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002416 ! caspase-8 isoform 5

[Term]
id: PR:Q14790-8
name: caspase-8 isoform 8 (human)
def: "A caspase-8 isoform 8 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:8" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform Beta-4 (human)" EXACT [UniProtKB:Q14790]
xref: UniProtKB:Q14790-8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002419 ! caspase-8 isoform 8

[Term]
id: PR:Q14790-9
name: caspase-8 isoform 9 (human)
def: "A caspase-8 isoform 9 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hCASP8/iso:9" EXACT PRO-short-label [PRO:DNx]
synonym: "caspase-8 isoform 8L (human)" BROAD [UniProtKB:Q14790]
xref: UniProtKB:Q14790-9
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002420 ! caspase-8 isoform 9