[Term]
id: PR:000036633
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 (mouse)
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 1 in mouse. UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]
comment: Category=organism-modification.
synonym: "mBCL2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10417-1, Ser-70, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003089 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P10417-1
name: apoptosis regulator Bcl-2 isoform Alpha (mouse)
def: "An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mBCL2/iso:Alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10417-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002383 ! apoptosis regulator Bcl-2 isoform 1

[Term]
id: PR:000027461
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]
comment: Category=organism-modification.
synonym: "hBCL2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10415-1, Thr-74, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027460 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated 2
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027460
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 2
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs on a Thr residue within the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]
comment: Category=modification.
synonym: "BCL2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003088 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027463
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]
comment: Category=organism-modification. This form is involved in macroautophagy. Phosphorylated by JNK1 during cell starvation.
synonym: "hBCL2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027462 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027462
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 3
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the three major phosphorylation sites (Thr and two conserved Ser residues) within the motif TSPLx(7-10)GPxLS, which is part of the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]
comment: Category=modification.
synonym: "BCL2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003088 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027465
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]
comment: Category=organism-modification. Induced by Cephalostatin 1. Phosphorylated by JNK kinases, JNK1 and JNK2.
synonym: "hBCL2/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027464 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated 4
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027464
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 4
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Thr and second Ser residue within the motif TSPLx(7-10)GPxLS, which is part of the the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]
comment: Category=modification.
synonym: "BCL2/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003088 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027467
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]
comment: Category=organism-modification. Phosphorylated by CDC2 kinase, during G(2)/M phase.
synonym: "hBCL2/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10415-1, Thr-56, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027466 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated 5
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027466
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 5
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser or Thr of the [TS]PxP motif, which is part of the non-structural N-terminal loop between BH4 and BH3 regions. Example: UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]
comment: Category=modification.
synonym: "BCL2/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003088 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q00709
name: apoptosis regulator Bcl-2 (chicken)
def: "An apoptosis regulator Bcl-2 that is encoded in the genome of chicken." [OMA:Q00709, PANTHER:PTHR11256:SF11, PRO:DNx]
comment: Category=organism-gene.
synonym: "BCL2" RELATED Gene-based [UniProtKB:Q00709]
synonym: "BCL-2" RELATED Gene-based [UniProtKB:Q00709]
synonym: "chick-BCL2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00709
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000002307 ! apoptosis regulator Bcl-2
relationship: has_gene_template NCBIGene:396282 ! BCL2 (chicken)

[Term]
id: PR:P10417
name: apoptosis regulator Bcl-2 (mouse)
def: "An apoptosis regulator Bcl-2 that is encoded in the genome of mouse." [OMA:P10417, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bcl2" RELATED Gene-based [UniProtKB:P10417]
synonym: "Bcl-2" RELATED Gene-based [UniProtKB:P10417]
synonym: "mBCL2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10417
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002307 ! apoptosis regulator Bcl-2
relationship: has_gene_template MGI:88138 ! Bcl2 (mouse)

[Term]
id: PR:P10417-2
name: apoptosis regulator Bcl-2 isoform Beta (mouse)
def: "An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of mouse." [PRO:JAN, PRO:SY]
comment: Category=organism-sequence.
synonym: "mBCL2/iso:Beta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10417-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002384 ! apoptosis regulator Bcl-2 isoform 2

[Term]
id: PR:000003089
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated 1
def: "An apoptosis regulator Bcl-2 isoform 1 phosphorylated form in which the phosphorylation occurs by the action of PKC. Example: UniProtKB:P10417-1, Ser-70, MOD:00046." [PMID:9115213, PMID:9852076, PRO:JAN]
comment: Category=modification.
synonym: "BCL2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003088 ! apoptosis regulator Bcl-2 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000003088
name: apoptosis regulator Bcl-2 isoform 1 phosphorylated form
def: "An apoptosis regulator Bcl-2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "BCL2/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000002383 ! apoptosis regulator Bcl-2 isoform 1

[Term]
id: PR:P10415
name: apoptosis regulator Bcl-2 (human)
def: "An apoptosis regulator Bcl-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P10415]
comment: Category=organism-gene.
synonym: "BCL2" RELATED Gene-based [UniProtKB:P10415]
synonym: "hBCL2" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-50757 "PR:P10415 located_in GO:0005741"
xref: UniProtKB:P10415
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002307 ! apoptosis regulator Bcl-2
relationship: has_gene_template HGNC:990 ! BCL2 (human)

[Term]
id: PR:P10415-2
name: apoptosis regulator Bcl-2 isoform Beta (human)
def: "An apoptosis regulator Bcl-2 isoform 2 that is encoded in the genome of human." [PRO:JAN, PRO:SY]
comment: Category=organism-sequence.
synonym: "hBCL2/iso:Beta" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10415-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002384 ! apoptosis regulator Bcl-2 isoform 2

[Term]
id: PR:P10415-1
name: apoptosis regulator Bcl-2 isoform Alpha (human)
def: "An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hBCL2/iso:Alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P10415-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002383 ! apoptosis regulator Bcl-2 isoform 1

[Term]
id: PR:000002307
name: apoptosis regulator Bcl-2
def: "A Bcl-2-like apoptosis inhibitor that is a translation product of the human BCL2 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "BCL2" EXACT PRO-short-label [PRO:DNx]
synonym: "Bcl-2" RELATED Gene-based []
xref: IUPHARobj:2844
is_a: PR:000002186 ! Bcl-2-like apoptosis inhibitor

[Term]
id: PR:000002384
name: apoptosis regulator Bcl-2 isoform 2
def: "An apoptosis regulator Bcl-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10415-2 or a 1:1 ortholog thereof." [PMID:3523487, PRO:DAN, PRO:JAN, PRO:SY]
comment: Category=sequence.
synonym: "BCL2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "apoptosis regulator Bcl-2 isoform beta" EXACT []
is_a: PR:000002307 ! apoptosis regulator Bcl-2

[Term]
id: PR:000002383
name: apoptosis regulator Bcl-2 isoform 1
def: "An apoptosis regulator Bcl-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10417-1 or a 1:1 ortholog thereof." [PMID:2834197, PMID:2875799, PRO:JAN]
comment: Category=sequence.
synonym: "BCL2/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Bcl2 isoform alpha" EXACT []
is_a: PR:000002307 ! apoptosis regulator Bcl-2

[Term]
id: PR:P49950
name: apoptosis regulator Bcl-2 (rat)
def: "An apoptosis regulator Bcl-2 that is encoded in the genome of rat." [OMA:P49950, PANTHER:PTHR11256:SF11, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bcl2" RELATED Gene-based [UniProtKB:P49950]
synonym: "Bcl-2" RELATED Gene-based [UniProtKB:P49950]
synonym: "rBCL2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49950
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002307 ! apoptosis regulator Bcl-2
relationship: has_gene_template RGD:2199 ! Bcl2 (rat)