[Term]
id: PR:000045576
name: inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 2 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated at Thr-23. UniProtKB:O15111, Thr-23, MOD:00047." [PMID:10485710, Reactome:R-HSA-177667, Reactome:R-HSA-198615, iPTMnet:O15111]
comment: Category=organism-modification.
synonym: "hCHUK/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15111, Thr-23, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198615 "PR:000045576 located_in GO:0005829"
is_a: PR:O15111 ! inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000001775
name: inhibitor of nuclear factor kappa-B kinase subunit alpha
def: "An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human CHUK gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "CHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK1" EXACT []
synonym: "IKKA" RELATED Gene-based []
synonym: "IKK-A" EXACT []
synonym: "IkBKA" EXACT []
synonym: "TCF16" RELATED Gene-based []
synonym: "TCF-16" EXACT []
synonym: "NFKBIKA" EXACT []
synonym: "IKK-alpha" EXACT []
synonym: "IkappaB kinase" EXACT []
synonym: "I-kappa-B kinase 1" EXACT []
synonym: "I-kappa-B kinase alpha" EXACT []
synonym: "transcription factor 16" EXACT []
synonym: "conserved helix-loop-helix ubiquitous kinase" EXACT []
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha" EXACT []
xref: IUPHARobj:1989
is_a: PR:000001774 ! inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits

[Term]
id: PR:000026823
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
comment: Category=organism-modification.
synonym: "phospho-IKK1" EXACT []
synonym: "hCHUK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026822 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:O15111-1
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hCHUK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15111-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026820 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

[Term]
id: PR:O15111
name: inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15111]
comment: Category=organism-gene.
synonym: "CHUK" RELATED Gene-based [UniProtKB:O15111]
synonym: "IKKA" RELATED Gene-based [UniProtKB:O15111]
synonym: "TCF16" RELATED Gene-based [UniProtKB:O15111]
synonym: "hCHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK1 (human)" EXACT [UniProtKB:O15111]
synonym: "IKK-A (human)" EXACT [UniProtKB:O15111]
synonym: "IkBKA (human)" EXACT [UniProtKB:O15111]
synonym: "TCF-16 (human)" EXACT [UniProtKB:O15111]
synonym: "NFKBIKA (human)" EXACT [UniProtKB:O15111]
synonym: "IKK-alpha (human)" EXACT [UniProtKB:O15111]
synonym: "IkappaB kinase (human)" EXACT [UniProtKB:O15111]
synonym: "I-kappa-B kinase 1 (human)" EXACT [UniProtKB:O15111]
synonym: "I-kappa-B kinase alpha (human)" EXACT [UniProtKB:O15111]
synonym: "transcription factor 16 (human)" EXACT [UniProtKB:O15111]
synonym: "conserved helix-loop-helix ubiquitous kinase (human)" EXACT [UniProtKB:O15111]
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha (human)" EXACT [UniProtKB:O15111]
xref: Reactome:R-HSA-168104 "PR:O15111 located_in GO:0005829"
xref: Reactome:R-HSA-1168562 "PR:O15111 located_in GO:0005886"
xref: DTO:03100181
xref: UniProtKB:O15111
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001775 ! inhibitor of nuclear factor kappa-B kinase subunit alpha
relationship: has_gene_template HGNC:1974 ! CHUK (human)