[Term]
id: PR:000001752
name: NF-kappa-B essential modulator
def: "A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160]
comment: Category=gene.
synonym: "FIP3" RELATED Gene-based []
synonym: "IKKG" EXACT []
synonym: "NEMO" RELATED Gene-based []
synonym: "FIP-3" EXACT []
synonym: "IKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKAP1" EXACT []
synonym: "IKK-gamma" EXACT []
synonym: "IkB kinase subunit gamma" EXACT []
synonym: "NF-kappa-B essential modifier" EXACT []
synonym: "I-kappa-B kinase subunit gamma" EXACT []
synonym: "IkB kinase-associated protein 1" EXACT []
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma" EXACT []
xref: PIRSF:PIRSF038160
is_a: PR:000000001 ! protein

[Term]
id: PR:000036613
name: NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIKBKG/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001767 ! NF-kappa-B essential modulator isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q9Y6K9-1
name: NF-kappa-B essential modulator isoform 1 (human)
def: "An NF-kappa-B essential modulator isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hIKBKG/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6K9-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001763 ! NF-kappa-B essential modulator isoform 1

[Term]
id: PR:000036612
name: NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIKBKG/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001766 ! NF-kappa-B essential modulator isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:O88522
name: NF-kappa-B essential modulator (mouse)
def: "An NF-kappa-B essential modulator that is encoded in the genome of mouse." [OMA:O88522, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nemo" RELATED Gene-based [UniProtKB:O88522]
synonym: "Ikbkg" RELATED Gene-based [UniProtKB:O88522]
synonym: "mFIP-3" EXACT [UniProtKB:O88522]
synonym: "mIKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKG (mouse)" EXACT [UniProtKB:O88522]
synonym: "NEMO (mouse)" RELATED []
synonym: "IKKAP1 (mouse)" EXACT [UniProtKB:O88522]
synonym: "IKK-gamma (mouse)" EXACT [UniProtKB:O88522]
synonym: "IkB kinase subunit gamma (mouse)" EXACT [UniProtKB:O88522]
synonym: "NF-kappa-B essential modifier (mouse)" EXACT [UniProtKB:O88522]
synonym: "I-kappa-B kinase subunit gamma (mouse)" EXACT [UniProtKB:O88522]
synonym: "IkB kinase-associated protein 1 (mouse)" EXACT [UniProtKB:O88522]
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma (mouse)" EXACT [UniProtKB:O88522]
xref: UniProtKB:O88522
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001752 ! NF-kappa-B essential modulator
relationship: has_gene_template MGI:1338074 ! Ikbkg (mouse)

[Term]
id: PR:Q9Y6K9
name: NF-kappa-B essential modulator (human)
def: "An NF-kappa-B essential modulator that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "FIP3" RELATED Gene-based [UniProtKB:Q9Y6K9]
synonym: "NEMO" RELATED Gene-based [UniProtKB:Q9Y6K9]
synonym: "IKBKG" RELATED Gene-based [UniProtKB:Q9Y6K9]
synonym: "hIKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKG (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "FIP-3 (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IKKAP1 (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IKK-gamma (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IkB kinase subunit gamma (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "NF-kappa-B essential modifier (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "I-kappa-B kinase subunit gamma (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IkB kinase-associated protein 1 (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma (human)" EXACT [UniProtKB:Q9Y6K9]
xref: UniProtKB:Q9Y6K9
xref: Reactome:R-HSA-168108 "PR:Q9Y6K9 located_in GO:0005829"
xref: Reactome:R-HSA-1168576 "PR:Q9Y6K9 located_in GO:0005886"
xref: Reactome:R-HSA-4755413 "PR:Q9Y6K9 located_in GO:0005654"
xref: DTO:03100364
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001752 ! NF-kappa-B essential modulator
relationship: has_gene_template HGNC:5961 ! IKBKG (human)

[Term]
id: PR:000047980
name: NF-kappa-B essential modulator ubiquitinated 1 (human)
def: "An NF-kappa-B essential modulator (human) that has been post-translationally modified to include ubiquitinated lysine at position 285 of the amino acid sequence represented by UniProtKB:Q9Y6K9. UniProtKB:Q9Y6K9, Lys-285, MOD:01148." [PRO:DNx, Reactome:R-HSA-741397]
comment: Category=organism-modification.
synonym: "hIKBKG/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9, Lys-285, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-741397 "PR:000047980 located_in GO:0005829"
is_a: PR:Q9Y6K9 ! NF-kappa-B essential modulator (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y6K9-3
name: NF-kappa-B essential modulator isoform h3 (human)
def: "An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-3." [PRO:DNx, UniProtKB:Q9Y6K9]
comment: Category=organism-sequence.
synonym: "hIKBKG/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6K9-3
is_a: PR:Q9Y6K9 ! NF-kappa-B essential modulator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y6K9-2
name: NF-kappa-B essential modulator isoform h2 (human)
def: "An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-2." [PRO:DNx, UniProtKB:Q9Y6K9]
comment: Category=organism-sequence.
synonym: "hIKBKG/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6K9-2
is_a: PR:Q9Y6K9 ! NF-kappa-B essential modulator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000001768
name: NF-kappa-B essential modulator isoform 1 phosphorylated 3
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated form in which the phosphorylation occurs on a Ser residue upon activation by genotoxic signals (through ATM). Example: UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA, PRO:DAN]
comment: Category=modification. Note: This phosphorylation promotes its ubiquitin-dependent nuclear export.
synonym: "IKBKG/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001765 ! NF-kappa-B essential modulator isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q6TMG5
name: NF-kappa-B essential modulator (rat)
def: "An NF-kappa-B essential modulator that is encoded in the genome of rat." [OMA:Q6TMG5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nemo" RELATED Gene-based [UniProtKB:Q6TMG5]
synonym: "Ikbkg" RELATED Gene-based [UniProtKB:Q6TMG5]
synonym: "rIKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKG (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "NEMO (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "IKKAP1 (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "IKK-gamma (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "IkB kinase subunit gamma (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "NF-kappa-B essential modifier (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "I-kappa-B kinase subunit gamma (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "IkB kinase-associated protein 1 (rat)" EXACT [UniProtKB:Q6TMG5]
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma (rat)" EXACT [UniProtKB:Q6TMG5]
xref: UniProtKB:Q6TMG5
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001752 ! NF-kappa-B essential modulator
relationship: has_gene_template RGD:735223 ! Ikbkg (rat)

[Term]
id: PR:000001766
name: NF-kappa-B essential modulator isoform 1 phosphorylated 1
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated form in which the phosphorylation occurs at two Ser residues within the IKK-binding region and at a Ser residue at the C-terminal region by activated IKK beta. Example: UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:DAN, PRO:JAN]
comment: Category=modification.
synonym: "IKBKG/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001765 ! NF-kappa-B essential modulator isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000001767
name: NF-kappa-B essential modulator isoform 1 phosphorylated 2
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue of the IKK-binding region by acivated IKK beta. Example: UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:DAN, PRO:JAN]
comment: Category=modification.
synonym: "IKBKG/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001765 ! NF-kappa-B essential modulator isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000001764
name: NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form
def: "An NF-kappa-B essential modulator isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:JAN]
comment: Category=modification.
synonym: "IKBKG/iso:1/PhosUbiq+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000001763 ! NF-kappa-B essential modulator isoform 1

[Term]
id: PR:000001765
name: NF-kappa-B essential modulator isoform 1 phosphorylated form
def: "An NF-kappa-B essential modulator isoform 1 that includes at least one phosphorylated residue." [PRO:JAN]
comment: Category=modification.
synonym: "IKBKG/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000001763 ! NF-kappa-B essential modulator isoform 1

[Term]
id: PR:000036614
name: NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIKBKG/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001768 ! NF-kappa-B essential modulator isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000001763
name: NF-kappa-B essential modulator isoform 1
def: "An NF-kappa-B essential modulator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "IKBKG/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001752 ! NF-kappa-B essential modulator