[Term]
id: PR:000001590
name: kappa-type opioid receptor
def: "An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin." [PRO:WCB, Wikipedia:kappa_Opioid_receptor]
comment: Category=gene.
synonym: "OPRK" RELATED Gene-based []
synonym: "KOR-1" EXACT []
synonym: "MSL-1" RELATED []
synonym: "OPRK1" EXACT PRO-short-label [PRO:DNx]
synonym: "K-OR-1" EXACT []
synonym: "kappa-opioid receptor" EXACT []
xref: IUPHARobj:318
is_a: PR:000001497 ! opioid receptor protein

[Term]
id: PR:P34975-1
name: kappa-type opioid receptor isoform 1 (rat)
def: "A kappa-type opioid receptor isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rOPRK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P34975-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039409 ! kappa-type opioid receptor isoform 1

[Term]
id: PR:P33534
name: kappa-type opioid receptor (mouse)
def: "A kappa-type opioid receptor that is encoded in the genome of mouse." [OMA:P33534, PRO:DNx]
comment: Category=organism-gene.
synonym: "Oprk1" RELATED Gene-based [UniProtKB:P33534]
synonym: "mOPRK1" EXACT PRO-short-label [PRO:DNx]
synonym: "KOR-1 (mouse)" EXACT [UniProtKB:P33534]
synonym: "MSL-1 (mouse)" EXACT [UniProtKB:P33534]
synonym: "K-OR-1 (mouse)" EXACT [UniProtKB:P33534]
xref: UniProtKB:P33534
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001590 ! kappa-type opioid receptor
relationship: has_gene_template MGI:97439 ! Oprk1 (mouse)

[Term]
id: PR:P41145-2
name: kappa-type opioid receptor isoform h2 (human)
def: "A kappa-type opioid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41145-2." [PRO:DNx, UniProtKB:P41145]
comment: Category=organism-sequence.
synonym: "hOPRK1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P41145-2
is_a: PR:P41145 ! kappa-type opioid receptor (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P41145
name: kappa-type opioid receptor (human)
def: "A kappa-type opioid receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P41145]
comment: Category=organism-gene.
synonym: "OPRK" RELATED Gene-based [UniProtKB:P41145]
synonym: "OPRK1" RELATED Gene-based [UniProtKB:P41145]
synonym: "hOPRK1" EXACT PRO-short-label [PRO:DNx]
synonym: "KOR-1 (human)" EXACT [UniProtKB:P41145]
synonym: "K-OR-1 (human)" EXACT [UniProtKB:P41145]
xref: Reactome:R-HSA-374286 "PR:P41145 located_in GO:0005886"
xref: DTO:02100469
xref: UniProtKB:P41145
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001590 ! kappa-type opioid receptor
relationship: has_gene_template HGNC:8154 ! OPRK1 (human)

[Term]
id: PR:P41145-1
name: kappa-type opioid receptor isoform 1 (human)
def: "A kappa-type opioid receptor isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hOPRK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P41145-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039409 ! kappa-type opioid receptor isoform 1

[Term]
id: PR:P34975
name: kappa-type opioid receptor (rat)
def: "A kappa-type opioid receptor that is encoded in the genome of rat." [OMA:P34975, PANTHER:PTHR24229:SF226, PRO:DNx]
comment: Category=organism-gene.
synonym: "Oprk1" RELATED Gene-based [UniProtKB:P34975]
synonym: "Ror-d" RELATED Gene-based [UniProtKB:P34975]
synonym: "rOPRK1" EXACT PRO-short-label [PRO:DNx]
synonym: "KOR-1 (rat)" EXACT [UniProtKB:P34975]
synonym: "K-OR-1 (rat)" EXACT [UniProtKB:P34975]
xref: UniProtKB:P34975
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001590 ! kappa-type opioid receptor
relationship: has_gene_template RGD:69426 ! Oprk1 (rat)

[Term]
id: PR:000049775
name: kappa-type opioid receptor phosphorylated 5 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at positions equivalent to Ser-356 and Ser-369 of the amino acid sequence represented by UniProtKB:P33534. UniProtKB:P33534, Ser-356/Ser-369, MOD:00046." [PMID:26635353, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26635353).
synonym: "mOPRK1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "KOPR phosphorylated 5 (mouse)" EXACT []
synonym: "UniProtKB:P33534, Ser-356/Ser-369, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049774
name: kappa-type opioid receptor phosphorylated 4 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at the position equivalent to Thr-363 of the amino acid sequence represented by UniProtKB:P33534. UniProtKB:P33534, Thr-363, MOD:00047." [PMID:26635353, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26635353).
synonym: "mOPRK1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "KOPR phosphorylated 4 (mouse)" EXACT []
synonym: "UniProtKB:P33534, Thr-363, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049777
name: kappa-type opioid receptor phosphorylated 7 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at positions equivalent to Thr-363 and Ser-369 of the amino acid sequence represented by UniProtKB:P33534. UniProtKB:P33534, Thr-363, MOD:00047|Ser-369, MOD:00046." [PMID:26635353, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26635353).
synonym: "mOPRK1/Phos:7" EXACT PRO-short-label [PRO:DNx]
synonym: "KOPR phosphorylated 7 (mouse)" EXACT []
synonym: "UniProtKB:P33534, Thr-363, MOD:00047|Ser-369, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049776
name: kappa-type opioid receptor phosphorylated 6 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at positions equivalent to Thr-357 and Ser-369 of the amino acid sequence represented by UniProtKB:P33534. UniProtKB:P33534, Thr-357, MOD:00047|Ser-369, MOD:00046." [PMID:26635353, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26635353).
synonym: "mOPRK1/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "KOPR phosphorylated 6 (mouse)" EXACT []
synonym: "UniProtKB:P33534, Thr-357, MOD:00047|Ser-369, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000039409
name: kappa-type opioid receptor isoform 1
def: "A kappa-type opioid receptor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41145-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "OPRK1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001590 ! kappa-type opioid receptor

[Term]
id: PR:000049773
name: kappa-type opioid receptor phosphorylated 3 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at the position equivalent to Thr-357 of the amino acid sequence represented by UniProtKB:P33534. UniProtKB:P33534, Thr-357, MOD:00047." [PMID:26635353, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26635353).
synonym: "mOPRK1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "KOPR phosphorylated 3 (mouse)" EXACT []
synonym: "UniProtKB:P33534, Thr-357, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049772
name: kappa-type opioid receptor phosphorylated 2 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at the position equivalent to Ser-356 of the amino acid sequence represented by UniProtKB:P33534. UniProtKB:P33534, Ser-356, MOD:00046." [PMID:26635353, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26635353).
synonym: "mOPRK1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "KOPR phosphorylated 2 (mouse)" EXACT []
synonym: "UniProtKB:P33534, Ser-356, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000046168
name: kappa-type opioid receptor phosphorylated 1 (mouse)
def: "A kappa-type opioid receptor (mouse) that has been phosphorylated at Ser-369. UniProtKB:P33534, Ser-369, MOD:00046." [PMID:14597630, iPTMnet:P33534]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:14597630). Status=unreviewed.
synonym: "mOPRK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P33534, Ser-369, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P33534 ! kappa-type opioid receptor (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P41144
name: kappa-type opioid receptor (guinea pig)
def: "A kappa-type opioid receptor that is encoded in the genome of guinea pig." [OMA:P41144, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "OPRK1" RELATED Gene-based [UniProtKB:P41144]
synonym: "gPig-OPRK1" EXACT PRO-short-label [PRO:DNx]
synonym: "KOR-1 (guinea pig)" EXACT [UniProtKB:P41144]
synonym: "K-OR-1 (guinea pig)" EXACT [UniProtKB:P41144]
xref: UniProtKB:P41144
intersection_of: only_in_taxon NCBITaxon:10141 ! Cavia porcellus
intersection_of: PR:000001590 ! kappa-type opioid receptor
relationship: has_gene_template NCBIGene:100135587 ! OPRK1 (guinea pig)

[Term]
id: PR:P33534-1
name: kappa-type opioid receptor isoform 1 (mouse)
def: "A kappa-type opioid receptor isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mOPRK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P33534-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039409 ! kappa-type opioid receptor isoform 1