[Term]
id: PR:000039066
name: interleukin-10 isoform 1
def: "An interleukin-10 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22301-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "IL10/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001471 ! interleukin-10

[Term]
id: PR:000001471
name: interleukin-10
def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof. Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds." [PANTHER:PTHR11585:SF1, PRO:JAN]
comment: Category=gene.
synonym: "CSIF" EXACT []
synonym: "IL10" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-10" EXACT []
synonym: "cytokine synthesis inhibitory factor" EXACT []
xref: PANTHER:PTHR11585:SF1
is_a: PR:000001335 ! class 2 cytokine, IL-10 type

[Term]
id: PR:P18893
name: interleukin-10 (mouse)
def: "An interleukin-10 that is encoded in the genome of mouse." [OMA:P18893, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il10" RELATED Gene-based [UniProtKB:P18893]
synonym: "Il-10" RELATED Gene-based [UniProtKB:P18893]
synonym: "mIL10" EXACT PRO-short-label [PRO:DNx]
synonym: "CSIF (mouse)" EXACT [UniProtKB:P18893]
synonym: "IL-10 (mouse)" EXACT [UniProtKB:P18893]
synonym: "cytokine synthesis inhibitory factor (mouse)" EXACT [UniProtKB:P18893]
xref: UniProtKB:P18893
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001471 ! interleukin-10
relationship: has_gene_template MGI:96537 ! Il10 (mouse)

[Term]
id: PR:P22301
name: interleukin-10 (human)
def: "An interleukin-10 that is encoded in the genome of human." [PRO:JAN, UniProtKB:P22301]
comment: Category=organism-gene.
synonym: "IL10" RELATED Gene-based [UniProtKB:P22301]
synonym: "hIL10" EXACT PRO-short-label [PRO:DNx]
synonym: "CSIF (human)" EXACT [UniProtKB:P22301]
synonym: "IL-10 (human)" EXACT [UniProtKB:P22301]
synonym: "cytokine synthesis inhibitory factor (human)" EXACT [UniProtKB:P22301]
xref: UniProtKB:P22301
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001471 ! interleukin-10
relationship: has_gene_template HGNC:5962 ! IL10 (human)

[Term]
id: PR:P29456-1
name: interleukin-10 isoform 1 (rat)
def: "An interleukin-10 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rIL10/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29456-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039066 ! interleukin-10 isoform 1

[Term]
id: PR:P18893-1
name: interleukin-10 isoform 1 (mouse)
def: "An interleukin-10 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mIL10/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18893-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039066 ! interleukin-10 isoform 1

[Term]
id: PR:Q6A2H4
name: interleukin-10 (chicken)
def: "An interleukin-10 that is encoded in the genome of chicken." [OMA:Q6A2H4, PANTHER:PTHR11585:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "IL10" RELATED Gene-based [UniProtKB:Q6A2H4]
synonym: "chick-IL10" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-10 (chicken)" EXACT [UniProtKB:Q6A2H4]
xref: UniProtKB:Q6A2H4
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001471 ! interleukin-10
relationship: has_gene_template NCBIGene:428264 ! IL10 (chicken)

[Term]
id: PR:P29456
name: interleukin-10 (rat)
def: "An interleukin-10 that is encoded in the genome of rat." [OMA:P29456, PANTHER:PTHR11585:SF1, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il10" RELATED Gene-based [UniProtKB:P29456]
synonym: "Il-10" RELATED Gene-based [UniProtKB:P29456]
synonym: "rIL10" EXACT PRO-short-label [PRO:DNx]
synonym: "CSIF (rat)" EXACT [UniProtKB:P29456]
synonym: "IL-10 (rat)" EXACT [UniProtKB:P29456]
synonym: "cytokine synthesis inhibitory factor (rat)" EXACT [UniProtKB:P29456]
xref: UniProtKB:P29456
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001471 ! interleukin-10
relationship: has_gene_template RGD:2886 ! Il10 (rat)

[Term]
id: PR:P22301-1
name: interleukin-10 isoform 1 (human)
def: "An interleukin-10 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hIL10/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22301-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039066 ! interleukin-10 isoform 1

[Term]
id: PR:000018500
name: interleukin-10, signal peptide removed form
def: "An interleukin-10 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL10/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001471 ! interleukin-10
intersection_of: lacks_part SO:0000418 ! signal_peptide