[Term]
id: PR:Q9VAC5
name: ADAM 17-like protease (fruit fly)
def: "An ADAM 17 endopeptidase that is encoded in the genome of fruit fly." [OMA:Q9VAC5, PANTHER:PTHR11905:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tace" RELATED Gene-based [UniProtKB:Q9VAC5]
synonym: "CG7908" RELATED Gene-based [UniProtKB:Q9VAC5]
synonym: "fly-ADAM17" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VAC5
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000001279 ! ADAM 17 endopeptidase
relationship: has_gene_template FlyBase:FBgn0039734 ! Tace (fruit fly)

[Term]
id: PR:000018362
name: ADAM 17 endopeptidase proteolytic cleavage product
def: "An ADAM 17 endopeptidase that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "ADAM17/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000001279 ! ADAM 17 endopeptidase

[Term]
id: PR:Q9VAC5-2
name: ADAM 17-like protease isoform B (fruit fly)
def: "An ADAM 17-like protease (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VAC5-2." [PRO:DNx, UniProtKB:Q9VAC5]
comment: Category=organism-sequence.
synonym: "fly-ADAM17/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VAC5-2
is_a: PR:Q9VAC5 ! ADAM 17-like protease (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q9Z0F8-2
name: disintegrin and metalloproteinase domain-containing protein 17 isoform Short (mouse)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z0F8-2." [PRO:DNx, UniProtKB:Q9Z0F8]
comment: Category=organism-sequence.
synonym: "mADAM17/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z0F8-2
is_a: PR:Q9Z0F8 ! disintegrin and metalloproteinase domain-containing protein 17 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q5QHR9
name: tumor necrosis factor alpha converting enzyme (chicken)
def: "An ADAM 17 endopeptidase that is encoded in the genome of chicken." [OMA:Q5QHR9, PRO:DNx]
comment: Category=organism-gene.
synonym: "chick-ADAM17" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5QHR9
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001279 ! ADAM 17 endopeptidase
relationship: has_gene_template CGNC:12298 ! ADAM17 (chicken)

[Term]
id: PR:Q9Z0F8-1
name: disintegrin and metalloproteinase domain-containing protein 17 isoform Long (mouse)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z0F8-1." [PRO:DNx, UniProtKB:Q9Z0F8]
comment: Category=organism-sequence.
synonym: "mADAM17/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z0F8-1
is_a: PR:Q9Z0F8 ! disintegrin and metalloproteinase domain-containing protein 17 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9Z1K9
name: disintegrin and metalloproteinase domain-containing protein 17 (rat)
def: "An ADAM 17 endopeptidase that is encoded in the genome of rat." [PANTHER:PTHR11905:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tace" RELATED Gene-based [UniProtKB:Q9Z1K9]
synonym: "Adam17" RELATED Gene-based [UniProtKB:Q9Z1K9]
synonym: "rADAM17" EXACT PRO-short-label [PRO:DNx]
synonym: "CD156b (rat)" EXACT [UniProtKB:Q9Z1K9]
synonym: "ADAM 17 (rat)" EXACT [UniProtKB:Q9Z1K9]
synonym: "TNF-alpha convertase (rat)" EXACT [UniProtKB:Q9Z1K9]
synonym: "TNF-alpha-converting enzyme (rat)" EXACT [UniProtKB:Q9Z1K9]
xref: UniProtKB:Q9Z1K9
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001279 ! ADAM 17 endopeptidase
relationship: has_gene_template RGD:620404 ! Adam17 (rat)

[Term]
id: PR:Q9VAC5-1
name: ADAM 17-like protease isoform A (fruit fly)
def: "An ADAM 17-like protease (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VAC5-1." [PRO:DNx, UniProtKB:Q9VAC5]
comment: Category=organism-sequence.
synonym: "fly-ADAM17/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VAC5-1
is_a: PR:Q9VAC5 ! ADAM 17-like protease (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:Q9Z0F8
name: disintegrin and metalloproteinase domain-containing protein 17 (mouse)
def: "An ADAM 17 endopeptidase that is encoded in the genome of mouse." [OMA:Q9Z0F8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tace" RELATED Gene-based [UniProtKB:Q9Z0F8]
synonym: "Adam17" RELATED Gene-based [UniProtKB:Q9Z0F8]
synonym: "mADAM17" EXACT PRO-short-label [PRO:DNx]
synonym: "CD156b (mouse)" EXACT [UniProtKB:Q9Z0F8]
synonym: "ADAM 17 (mouse)" EXACT [UniProtKB:Q9Z0F8]
synonym: "TNF-alpha convertase (mouse)" EXACT [UniProtKB:Q9Z0F8]
synonym: "TNF-alpha-converting enzyme (mouse)" EXACT [UniProtKB:Q9Z0F8]
xref: UniProtKB:Q9Z0F8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001279 ! ADAM 17 endopeptidase
relationship: has_gene_template MGI:1096335 ! Adam17 (mouse)

[Term]
id: PR:P78536
name: disintegrin and metalloproteinase domain-containing protein 17 (human)
def: "An ADAM 17 endopeptidase that is encoded in the genome of human." [PRO:WCB, UniProtKB:P78536]
comment: Category=organism-gene.
synonym: "CSVP" RELATED Gene-based [UniProtKB:P78536]
synonym: "TACE" RELATED Gene-based [UniProtKB:P78536]
synonym: "ADAM17" RELATED Gene-based [UniProtKB:P78536]
synonym: "hADAM17" EXACT PRO-short-label [PRO:DNx]
synonym: "CD156b (human)" EXACT [UniProtKB:P78536]
synonym: "ADAM 17 (human)" EXACT [UniProtKB:P78536]
synonym: "TNF-alpha convertase (human)" EXACT [UniProtKB:P78536]
synonym: "snake venom-like protease (human)" EXACT [UniProtKB:P78536]
synonym: "TNF-alpha-converting enzyme (human)" EXACT [UniProtKB:P78536]
xref: Reactome:R-HSA-9662835 "PR:P78536 located_in GO:0000139"
xref: UniProtKB:P78536
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001279 ! ADAM 17 endopeptidase
relationship: has_gene_template HGNC:195 ! ADAM17 (human)

[Term]
id: PR:000045859
name: disintegrin and metalloproteinase domain-containing protein 17 phosphorylated 1 (human)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (human) that has been phosphorylated at the position equivalent to Thr-735 of the amino acid sequence represented by UniProtKB:P78536-1. Example: UniProtKB:P78536-1, Thr-735, MOD:00047." [PMID:12058067, PMID:18722532, iPTMnet:P78536]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12058067, PMID:18722532). Status=unreviewed.
synonym: "hADAM17/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P78536-1, Thr-735, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P78536 ! disintegrin and metalloproteinase domain-containing protein 17 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P78536-2
name: disintegrin and metalloproteinase domain-containing protein 17 isoform B (human)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78536-2." [PRO:DNx, UniProtKB:P78536]
comment: Category=organism-sequence.
synonym: "hADAM17/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P78536-2
is_a: PR:P78536 ! disintegrin and metalloproteinase domain-containing protein 17 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000056692
name: disintegrin and metalloproteinase domain-containing protein 17 N-glycosylated 2 (human)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (human) that has been N-glycosylated at the residue equivalent to Asn-264 of the amino acid sequence represented by UniProtKB:P78536-1, in which the glycan composition is represented by GlyTouCan:G83633GK. Example: UniProtKB:P78536-1, Asn-264, MOD:00160~GNO:G83633GK." [GlyGen:P78536-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hADAM17/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P78536-1, Asn-264, MOD:00160~GNO:G83633GK" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P78536 ! disintegrin and metalloproteinase domain-containing protein 17 (human)
relationship: has_part GNO:G83633GK ! G83633GK
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P78536-1
name: disintegrin and metalloproteinase domain-containing protein 17 isoform A (human)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P78536-1." [PRO:DNx, UniProtKB:P78536]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hADAM17/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P78536-1
is_a: PR:P78536 ! disintegrin and metalloproteinase domain-containing protein 17 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q94316
name: disintegrin and metalloproteinase domain-containing protein 17 homolog (worm)
def: "An ADAM 17 endopeptidase that is encoded in the genome of worm." [PANTHER:PTHR11905:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "adm-4" RELATED Gene-based [UniProtKB:Q94316]
synonym: "ZK154.7" RELATED Gene-based [UniProtKB:Q94316]
synonym: "ADAM17 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "ADAM 17 homolog (worm)" EXACT [UniProtKB:Q94316]
xref: UniProtKB:Q94316
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000001279 ! ADAM 17 endopeptidase
relationship: has_gene_template WormBase:WBGene00000075 ! adm-4 (worm)

[Term]
id: PR:000056691
name: disintegrin and metalloproteinase domain-containing protein 17 N-glycosylated 1 (human)
def: "A disintegrin and metalloproteinase domain-containing protein 17 (human) that has been N-glycosylated at the residue equivalent to Asn-264 of the amino acid sequence represented by UniProtKB:P78536-1, in which the glycan composition is represented by GlyTouCan:G37399XV. Example: UniProtKB:P78536-1, Asn-264, MOD:00160~GNO:G37399XV." [GlyGen:P78536-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hADAM17/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P78536-1, Asn-264, MOD:00160~GNO:G37399XV" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P78536 ! disintegrin and metalloproteinase domain-containing protein 17 (human)
relationship: has_part GNO:G37399XV ! G37399XV
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000001279
name: ADAM 17 endopeptidase
def: "A protein that is a translation product of the human ADAM17 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "CSVP" RELATED Gene-based []
synonym: "TACE" RELATED Gene-based []
synonym: "ADAM17" EXACT PRO-short-label [PRO:DNx]
synonym: "CD156b" EXACT []
synonym: "ADAM 17" EXACT []
synonym: "TNF-alpha convertase" EXACT []
synonym: "snake venom-like protease" EXACT []
synonym: "TNF-alpha-converting enzyme" EXACT []
xref: IUPHARobj:1662
is_a: PR:000000001 ! protein