[Term]
id: PR:000001229
name: interleukin-1 receptor antagonist protein isoform 2
def: "An interleukin-1 receptor antagonist protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18510-2 or a 1:1 ortholog thereof." [PMID:1827201, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "icIL-1ra" RELATED []
synonym: "IL1RN/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001137 ! interleukin-1 receptor antagonist protein

[Term]
id: PR:000001228
name: interleukin-1 receptor antagonist protein isoform 1
def: "An interleukin-1 receptor antagonist protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18510-1 or a 1:1 ortholog thereof." [PMID:2139180, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "sIL-1ra" EXACT []
synonym: "IL1RN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001137 ! interleukin-1 receptor antagonist protein

[Term]
id: PR:P25085
name: interleukin-1 receptor antagonist protein (mouse)
def: "An interleukin-1 receptor antagonist protein that is encoded in the genome of mouse." [OMA:P25085, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il1rn" RELATED Gene-based [UniProtKB:P25085]
synonym: "Il-1ra" RELATED Gene-based [UniProtKB:P25085]
synonym: "mIL1RN" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAP (mouse)" EXACT [UniProtKB:P25085]
synonym: "IL-1RN (mouse)" EXACT [UniProtKB:P25085]
synonym: "IL-1ra (mouse)" EXACT [UniProtKB:P25085]
synonym: "IL1 inhibitor (mouse)" EXACT [UniProtKB:P25085]
xref: UniProtKB:P25085
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001137 ! interleukin-1 receptor antagonist protein
relationship: has_gene_template MGI:96547 ! Il1rn (mouse)

[Term]
id: PR:000001230
name: interleukin-1 receptor antagonist protein isoform 3
def: "An interleukin-1 receptor antagonist protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18510-3 or a 1:1 ortholog thereof." [PMID:7629520, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "IL1RN/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "icIL-1ra type II" EXACT []
is_a: PR:000001137 ! interleukin-1 receptor antagonist protein

[Term]
id: PR:000001231
name: interleukin-1 receptor antagonist protein isoform 4
def: "An interleukin-1 receptor antagonist protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18510-4 or a 1:1 ortholog thereof." [PMID:9514884, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "IL1RN/iso:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001137 ! interleukin-1 receptor antagonist protein

[Term]
id: PR:P18510-4
name: interleukin-1 receptor antagonist protein isoform 4 (human)
def: "An interleukin-1 receptor antagonist protein isoform 4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P18510]
comment: Category=organism-sequence.
synonym: "hIL1RN/iso:4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18510-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001231 ! interleukin-1 receptor antagonist protein isoform 4

[Term]
id: PR:P18510-3
name: interleukin-1 receptor antagonist protein isoform 3 (human)
def: "An interleukin-1 receptor antagonist protein isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P18510]
comment: Category=organism-sequence.
synonym: "hIL1RN/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor antagonist protein isoform icIL-1ra type II (human)" EXACT [UniProtKB:P18510]
xref: UniProtKB:P18510-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001230 ! interleukin-1 receptor antagonist protein isoform 3

[Term]
id: PR:P18510-2
name: interleukin-1 receptor antagonist protein isoform 2 (human)
def: "An interleukin-1 receptor antagonist protein isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P18510]
comment: Category=organism-sequence.
synonym: "hIL1RN/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor antagonist protein isoform icIL-1ra (human)" EXACT [UniProtKB:P18510]
xref: UniProtKB:P18510-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001229 ! interleukin-1 receptor antagonist protein isoform 2

[Term]
id: PR:P18510-1
name: interleukin-1 receptor antagonist protein isoform 1 (human)
def: "An interleukin-1 receptor antagonist protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIL1RN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P18510-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001228 ! interleukin-1 receptor antagonist protein isoform 1

[Term]
id: PR:000025427
name: interleukin-1 receptor antagonist protein proteolytic cleavage product
def: "An interleukin-1 receptor antagonist protein that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "IL1RN/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000001137 ! interleukin-1 receptor antagonist protein

[Term]
id: PR:P18510
name: interleukin-1 receptor antagonist protein (human)
def: "An interleukin-1 receptor antagonist protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P18510]
comment: Category=organism-gene.
synonym: "IL1F3" RELATED Gene-based [UniProtKB:P18510]
synonym: "IL1RA" RELATED Gene-based [UniProtKB:P18510]
synonym: "IL1RN" RELATED Gene-based [UniProtKB:P18510]
synonym: "hIL1RN" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAP (human)" BROAD [UniProtKB:P18510]
synonym: "IL-1RN (human)" EXACT [UniProtKB:P18510]
synonym: "IL-1ra (human)" EXACT [UniProtKB:P18510]
synonym: "ICIL-1RA (human)" EXACT [UniProtKB:P18510]
synonym: "anakinra (human)" EXACT [UniProtKB:P18510]
synonym: "IL1 inhibitor (human)" EXACT [UniProtKB:P18510]
xref: UniProtKB:P18510
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001137 ! interleukin-1 receptor antagonist protein
relationship: has_gene_template HGNC:6000 ! IL1RN (human)

[Term]
id: PR:P25086
name: interleukin-1 receptor antagonist protein (rat)
def: "An interleukin-1 receptor antagonist protein that is encoded in the genome of rat." [PANTHER:PTHR10078:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Il1rn" RELATED Gene-based [UniProtKB:P25086]
synonym: "Il-1ra" RELATED Gene-based [UniProtKB:P25086]
synonym: "rIL1RN" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAP (rat)" RELATED [UniProtKB:P25086]
synonym: "IL-1RN (rat)" EXACT [UniProtKB:P25086]
synonym: "IL-1ra (rat)" EXACT [UniProtKB:P25086]
synonym: "IL1 inhibitor (rat)" EXACT [UniProtKB:P25086]
xref: UniProtKB:P25086
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001137 ! interleukin-1 receptor antagonist protein
relationship: has_gene_template RGD:621159 ! Il1rn (rat)

[Term]
id: PR:000001271
name: interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form
def: "An interleukin-1 receptor antagonist protein isoform 1 that has had the signal peptide removed to yield the mature form." [PMID:2139180]
comment: Category=modification.
synonym: "IL1RN/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor antagonist protein isoform 1 cleaved 1" EXACT []
intersection_of: PR:000001228 ! interleukin-1 receptor antagonist protein isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P25085-2
name: interleukin-1 receptor antagonist protein isoform 2 (mouse)
def: "An interleukin-1 receptor antagonist protein isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P25085]
comment: Category=organism-sequence.
synonym: "mIL1RN/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25085-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001229 ! interleukin-1 receptor antagonist protein isoform 2

[Term]
id: PR:000001137
name: interleukin-1 receptor antagonist protein
def: "A protein that is a translation product of the human IL1RN gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene. Note: The active form inhibits the activity of IL-1 by binding to its receptor.
synonym: "IRAP" EXACT []
synonym: "IL1F3" RELATED Gene-based []
synonym: "IL1RA" RELATED Gene-based []
synonym: "IL1RN" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-1RN" EXACT []
synonym: "IL-1ra" EXACT []
synonym: "ICIL-1RA" EXACT []
synonym: "anakinra" EXACT []
synonym: "IL1 inhibitor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000018347
name: interleukin-1 receptor antagonist protein, signal peptide removed form
def: "An interleukin-1 receptor antagonist protein that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IL1RN/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001137 ! interleukin-1 receptor antagonist protein
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000036601
name: interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form (human)
def: "An interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form in human. UniProtKB:P18510-1, 26-177." [PMID:2139180, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000015328" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hIL1RN/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P18510-1, 26-177" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-445743 "PR:000036601 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001271 ! interleukin-1 receptor antagonist protein isoform 1, signal peptide removed form

[Term]
id: PR:P25085-1
name: interleukin-1 receptor antagonist protein isoform 1 (mouse)
def: "An interleukin-1 receptor antagonist protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mIL1RN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25085-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001228 ! interleukin-1 receptor antagonist protein isoform 1