[Term]
id: PR:000001092
name: interleukin-17
def: "A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses." [PMID:17982105, PMID:18280574]
comment: Category=family.
synonym: "IL17" EXACT []
synonym: "fam:IL-17" EXACT PRO-short-label [PRO:DAN]
xref: PIRSF:PIRSF003430
xref: PANTHER:PTHR21295
is_a: PR:000000001 ! protein