[Term]
id: PR:Q9UGI6-3
name: small conductance calcium-activated potassium channel protein 3 isoform h3 (human)
def: "A small conductance calcium-activated potassium channel protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGI6-3." [PRO:DNx, UniProtKB:Q9UGI6]
comment: Category=organism-sequence.
synonym: "hKCNN3/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "small conductance calcium-activated potassium channel protein 3 isoform SK3-1B (human)" EXACT [UniProtKB:Q9UGI6]
xref: UniProtKB:Q9UGI6-3
is_a: PR:Q9UGI6 ! small conductance calcium-activated potassium channel protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000029956
name: small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)
def: "A small conductance calcium-activated potassium channel protein 3 (human) that has a C-terminal truncation due to frameshift and premature stop, such that the sequence is equivalent to UniProtKB:Q9UGI6-1, 1-283, plus the residues TML. The truncated protein lacks the transmembrane and the calmodulin binding domains. However, it conserves the two glutamine rich domains." [PMID:11395478, PRO:DAN]
comment: Category=organism-sequence. Note: The referenced paper shows a sequence that is itself based on a variant of the canonical sequence. The sequence of the variant is EMBL:AAC26099.
synonym: "hKCNN3/var:1" EXACT PRO-short-label [PRO:DAN]
synonym: "SKCa3Delta (human)" EXACT [PRO:DAN, PMID:11395478]
is_a: PR:Q9UGI6 ! small conductance calcium-activated potassium channel protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9UGI6-1
name: small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
def: "A small conductance calcium-activated potassium channel protein 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCNN3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UGI6-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000773 ! small conductance calcium-activated potassium channel protein 3 isoform 1

[Term]
id: PR:Q9UGI6-2
name: small conductance calcium-activated potassium channel protein 3 isoform h2 (human)
def: "A small conductance calcium-activated potassium channel protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGI6-2." [PRO:DNx, UniProtKB:Q9UGI6]
comment: Category=organism-sequence.
synonym: "hKCNN3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9UGI6-2
is_a: PR:Q9UGI6 ! small conductance calcium-activated potassium channel protein 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000714
name: small conductance calcium-activated potassium channel protein 3
def: "A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN3 gene or a 1:1 ortholog thereof. The KCNN3 gene contains two arrays of CAG trinucleotide repeats, which are highly polymorphic. The SK3 channels are thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization." [PRO:CNA]
comment: Category=gene.
synonym: "K3" RELATED Gene-based []
synonym: "SK3" EXACT []
synonym: "KCNN3" EXACT PRO-short-label [PRO:DNx]
synonym: "SKCa3" EXACT []
synonym: "KCa2.3" EXACT []
synonym: "SKCa 3" EXACT []
xref: IUPHARobj:383
is_a: PR:000000668 ! calcium-activated calmodulin-binding potassium channel alpha subunit

[Term]
id: PR:Q9UGI6
name: small conductance calcium-activated potassium channel protein 3 (human)
def: "A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UGI6]
comment: Category=organism-gene.
synonym: "K3" RELATED Gene-based [UniProtKB:Q9UGI6]
synonym: "KCNN3" RELATED Gene-based [UniProtKB:Q9UGI6]
synonym: "hKCNN3" EXACT PRO-short-label [PRO:DNx]
synonym: "SK3 (human)" EXACT [UniProtKB:Q9UGI6]
synonym: "SKCa3 (human)" EXACT [UniProtKB:Q9UGI6]
synonym: "KCa2.3 (human)" EXACT [UniProtKB:Q9UGI6]
synonym: "SKCa 3 (human)" EXACT [UniProtKB:Q9UGI6]
xref: UniProtKB:Q9UGI6
xref: Reactome:R-HSA-977490 "PR:Q9UGI6 located_in GO:0005886"
xref: DTO:01100230
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000714 ! small conductance calcium-activated potassium channel protein 3
relationship: has_gene_template HGNC:6292 ! KCNN3 (human)