[Term]
id: PR:000000702
name: modulatory voltage-gated potassium channel subunit KCNS
def: "A voltage-gated potassium channel alpha subunit that is a modulator of the shab-related potassium channels (Kv2). Similarly to KCNF1, KCNV and KCNG subunits, KCNS subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIT. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PMID:12642579, PMID:9305895]
comment: Category=family.
synonym: "silent subunit" RELATED []
synonym: "fam:Kchan_sub-KCNS" EXACT PRO-short-label [PRO:DAN]
xref: PIRSF:PIRSF500981
is_a: PR:000000685 ! voltage-gated potassium channel alpha subunit