[Term]
id: PR:O89109-1
name: intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
def: "An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mKCNN4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O89109-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000753 ! intermediate conductance calcium-activated potassium channel protein 4 isoform 1

[Term]
id: PR:000000753
name: intermediate conductance calcium-activated potassium channel protein 4 isoform 1
def: "An intermediate conductance calcium-activated potassium channel protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15554-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "KCNN4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000700 ! intermediate conductance calcium-activated potassium channel protein 4

[Term]
id: PR:O15554-1
name: intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
def: "An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCNN4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15554-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000753 ! intermediate conductance calcium-activated potassium channel protein 4 isoform 1

[Term]
id: PR:O89109
name: intermediate conductance calcium-activated potassium channel protein 4 (mouse)
def: "An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of mouse." [OMA:O89109, PRO:DNx]
comment: Category=organism-gene.
synonym: "Kcnn4" RELATED Gene-based [UniProtKB:O89109]
synonym: "mKCNN4" EXACT PRO-short-label [PRO:DNx]
synonym: "IK1 (mouse)" EXACT [UniProtKB:O89109]
synonym: "SK4 (mouse)" EXACT [UniProtKB:O89109]
synonym: "KCa4 (mouse)" EXACT [UniProtKB:O89109]
synonym: "SKCa4 (mouse)" EXACT [UniProtKB:O89109]
synonym: "KCa3.1 (mouse)" EXACT [UniProtKB:O89109]
synonym: "SKCa 4 (mouse)" EXACT [UniProtKB:O89109]
xref: UniProtKB:O89109
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000700 ! intermediate conductance calcium-activated potassium channel protein 4
relationship: has_gene_template MGI:1277957 ! Kcnn4 (mouse)

[Term]
id: PR:000000700
name: intermediate conductance calcium-activated potassium channel protein 4
def: "A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042]
comment: Category=gene.
synonym: "IK1" RELATED Gene-based []
synonym: "SK4" RELATED Gene-based []
synonym: "KCA4" RELATED Gene-based []
synonym: "KCa4" EXACT []
synonym: "IKCA1" RELATED Gene-based []
synonym: "IKCa1" EXACT []
synonym: "KCNN4" EXACT PRO-short-label [PRO:DNx]
synonym: "SKCa4" EXACT []
synonym: "KCa3.1" EXACT []
synonym: "SKCa 4" EXACT []
synonym: "putative Gardos channel" EXACT []
xref: IUPHARobj:384
is_a: PR:000000668 ! calcium-activated calmodulin-binding potassium channel alpha subunit

[Term]
id: PR:O15554
name: intermediate conductance calcium-activated potassium channel protein 4 (human)
def: "An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "IK1" RELATED Gene-based [UniProtKB:O15554]
synonym: "SK4" RELATED Gene-based [UniProtKB:O15554]
synonym: "KCA4" RELATED Gene-based [UniProtKB:O15554]
synonym: "IKCA1" RELATED Gene-based [UniProtKB:O15554]
synonym: "KCNN4" RELATED Gene-based [UniProtKB:O15554]
synonym: "hIKCa1" EXACT [PRO:DAN, PMID:10026195]
synonym: "hKCNN4" EXACT PRO-short-label [PRO:DNx]
synonym: "SKCa4 (human)" EXACT [UniProtKB:O15554]
synonym: "KCa3.1 (human)" EXACT [UniProtKB:O15554]
synonym: "SKCa 4 (human)" EXACT [UniProtKB:O15554]
synonym: "putative Gardos channel (human)" EXACT [UniProtKB:O15554]
xref: Reactome:R-HSA-977543 "PR:O15554 located_in GO:0005886"
xref: DTO:01100231
xref: UniProtKB:O15554
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000700 ! intermediate conductance calcium-activated potassium channel protein 4
relationship: has_gene_template HGNC:6293 ! KCNN4 (human)

[Term]
id: PR:Q9QYW1
name: intermediate conductance calcium-activated potassium channel protein 4 (rat)
def: "An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of rat." [PANTHER:PTHR10153:SF4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ik1" RELATED Gene-based [UniProtKB:Q9QYW1]
synonym: "Sk4" RELATED Gene-based [UniProtKB:Q9QYW1]
synonym: "Smik" RELATED Gene-based [UniProtKB:Q9QYW1]
synonym: "Kcnn4" RELATED Gene-based [UniProtKB:Q9QYW1]
synonym: "rKCNN4" EXACT PRO-short-label [PRO:DNx]
synonym: "IK1 (rat)" EXACT [UniProtKB:Q9QYW1]
synonym: "SK4 (rat)" EXACT [UniProtKB:Q9QYW1]
synonym: "KCa4 (rat)" EXACT [UniProtKB:Q9QYW1]
synonym: "SKCa4 (rat)" EXACT [UniProtKB:Q9QYW1]
synonym: "KCa3.1 (rat)" EXACT [UniProtKB:Q9QYW1]
synonym: "SKCa 4 (rat)" EXACT [UniProtKB:Q9QYW1]
xref: UniProtKB:Q9QYW1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000700 ! intermediate conductance calcium-activated potassium channel protein 4
relationship: has_gene_template RGD:621476 ! Kcnn4 (rat)