[Term]
id: PR:000000678
name: sodium leak channel NALCN
def: "An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel." [PMID:17448995, PRO:CNA]
comment: Category=gene. Note: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849]
synonym: "NALCN" EXACT PRO-short-label [PRO:DNx]
synonym: "CanIon" EXACT []
synonym: "VGCNL1" RELATED Gene-based []
synonym: "voltage gated channel-like protein 1" EXACT []
synonym: "sodium leak channel non-selective protein" EXACT []
xref: IUPHARobj:750
xref: PIRSF:PIRSF038547
is_a: PR:000049983 ! ion channel protein