[Term]
id: PR:000002581
name: cation channel sperm-associated protein 1 isoform 1 unmodified form
def: "A cation channel sperm-associated protein 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "CATSPER1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000688 ! cation channel sperm-associated protein 1 isoform 1
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000000669
name: cation channel sperm-associated protein 1
def: "A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents." [PRO:CNA]
comment: Category=gene.
synonym: "CatSper" BROAD [PRO:DAN]
synonym: "CATSPER1" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper1" EXACT []
xref: IUPHARobj:388
is_a: PR:000044645 ! CatSper channel protein

[Term]
id: PR:Q91ZR5
name: cation channel sperm-associated protein 1 (mouse)
def: "A cation channel sperm-associated protein 1 that is encoded in the genome of mouse." [OMA:Q91ZR5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Catsper1" RELATED Gene-based [UniProtKB:Q91ZR5]
synonym: "mCATSPER1" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper1 (mouse)" EXACT [UniProtKB:Q91ZR5]
xref: UniProtKB:Q91ZR5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000669 ! cation channel sperm-associated protein 1
relationship: has_gene_template MGI:2179947 ! Catsper1 (mouse)

[Term]
id: PR:000000688
name: cation channel sperm-associated protein 1 isoform 1
def: "A cation channel sperm-associated protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZR5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "CATSPER1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000669 ! cation channel sperm-associated protein 1

[Term]
id: PR:Q8NEC5
name: cation channel sperm-associated protein 1 (human)
def: "A cation channel sperm-associated protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8NEC5]
comment: Category=organism-gene.
synonym: "CATSPER1" RELATED Gene-based [UniProtKB:Q8NEC5]
synonym: "hCatSper" EXACT [UniProtKB:Q8NEC5]
synonym: "hCATSPER1" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper1 (human)" EXACT [UniProtKB:Q8NEC5]
xref: UniProtKB:Q8NEC5
xref: Reactome:R-HSA-2534335 "PR:Q8NEC5 located_in GO:0005886"
xref: DTO:01100093
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000669 ! cation channel sperm-associated protein 1
relationship: has_gene_template HGNC:17116 ! CATSPER1 (human)

[Term]
id: PR:Q8NEC5-1
name: cation channel sperm-associated protein 1 isoform 1 (human)
def: "A cation channel sperm-associated protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NEC5-1." [PRO:DNx, UniProtKB:Q8NEC5]
comment: Category=organism-sequence.
synonym: "hCATSPER1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8NEC5-1
is_a: PR:Q8NEC5 ! cation channel sperm-associated protein 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q91ZR5-1
name: cation channel sperm-associated protein 1 isoform 1 (mouse)
def: "A cation channel sperm-associated protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCATSPER1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91ZR5-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000688 ! cation channel sperm-associated protein 1 isoform 1