[Term]
id: PR:000000523
name: TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
def: "A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
comment: Category=modification.
synonym: "TGFBR1 active" EXACT []
synonym: "TGFBR1/iso:1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000408 ! TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine