[Term]
id: PR:000049285
name: mothers against decapentaplegic homolog 3 phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 3 (human) that has been post-translationally modified to include phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-171184, Reactome:R-HSA-177104]
comment: Category=organism-modification.
synonym: "hSMAD3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84022, Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-177104 "PR:000049285 located_in GO:0005654"
xref: Reactome:R-HSA-171184 "PR:000049285 located_in GO:0005829"
is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P84022-1
name: mothers against decapentaplegic homolog 3 isoform 1 (human)
def: "A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hSMAD3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P84022-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000475 ! smad3 isoform 1

[Term]
id: PR:000049287
name: mothers against decapentaplegic homolog 3 ubiquitinated form (human)
def: "A mothers against decapentaplegic homolog 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:P84022, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782830]
comment: Category=organism-modification.
synonym: "hSMAD3/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84022, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782830 "PR:000049287 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049286
name: mothers against decapentaplegic homolog 3 phosphorylated 2 (human)
def: "A mothers against decapentaplegic homolog 3 (human) that has been post-translationally modified to include phosphothreonine at position 179, and phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2176471]
comment: Category=organism-modification.
synonym: "hSMAD3/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2176471 "PR:000049286 located_in GO:0005654"
is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P84022-4
name: mothers against decapentaplegic homolog 3 isoform h4 (human)
def: "A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-4." [PRO:DNx, UniProtKB:P84022]
comment: Category=organism-sequence.
synonym: "hSMAD3/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P84022-4
is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P84022
name: mothers against decapentaplegic homolog 3 (human)
def: "A smad3 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH3" RELATED Gene-based [UniProtKB:P84022]
synonym: "SMAD3" RELATED Gene-based [UniProtKB:P84022]
synonym: "hMAD-3" EXACT [UniProtKB:P84022]
synonym: "hSMAD3" EXACT PRO-short-label [PRO:DNx]
synonym: "Mad3 (human)" EXACT [UniProtKB:P84022]
synonym: "Smad3 (human)" EXACT [UniProtKB:P84022]
synonym: "JV15-2 (human)" EXACT [UniProtKB:P84022]
synonym: "SMAD 3 (human)" EXACT [UniProtKB:P84022]
synonym: "MAD homolog 3 (human)" EXACT [UniProtKB:P84022]
synonym: "SMAD family member 3 (human)" EXACT [UniProtKB:P84022]
synonym: "mothers against DPP homolog 3 (human)" EXACT [UniProtKB:P84022]
xref: Reactome:R-HSA-206150 "PR:P84022 located_in GO:0005654"
xref: Reactome:R-HSA-170855 "PR:P84022 located_in GO:0005829"
xref: UniProtKB:P84022
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000365 ! smad3
relationship: has_gene_template HGNC:6769 ! SMAD3 (human)

[Term]
id: PR:P84022-2
name: mothers against decapentaplegic homolog 3 isoform h2 (human)
def: "A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-2." [PRO:DNx, UniProtKB:P84022]
comment: Category=organism-sequence.
synonym: "hSMAD3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P84022-2
is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000365
name: smad3
def: "A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995]
comment: Category=gene.
synonym: "mad3" EXACT []
synonym: "MAD-3" EXACT []
synonym: "MADH3" RELATED Gene-based []
synonym: "SMAD3" EXACT PRO-short-label [PRO:DNx]
synonym: "JV15-2" EXACT []
synonym: "SMAD 3" EXACT []
synonym: "MAD homolog 3" EXACT []
synonym: "SMAD family member 3" EXACT []
synonym: "mothers against DPP homolog 3" EXACT []
is_a: PR:000000066 ! TGF-beta receptor-regulated smad protein

[Term]
id: PR:P84022-3
name: mothers against decapentaplegic homolog 3 isoform h3 (human)
def: "A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-3." [PRO:DNx, UniProtKB:P84022]
comment: Category=organism-sequence.
synonym: "hSMAD3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P84022-3
is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026333
name: smad3 isoform 1 phosphorylated 1 (human)
def: "A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]
comment: Category=organism-modification.
synonym: "hSMAD3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000658 ! smad3 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036557
name: smad3 isoform 1 acetylated and phosphorylated 1 (human)
def: "A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD3/iso:1/AcPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P84022-1, Lys-19, MOD:00394|Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000657 ! smad3 isoform 1 acetylated and phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine