[Term]
id: PR:P06804-1
name: tumor necrosis factor isoform 1 (mouse)
def: "A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTNF/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06804-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000381 ! tumor necrosis factor isoform 1

[Term]
id: PR:P06804
name: tumor necrosis factor (mouse)
def: "A tumor necrosis factor that is encoded in the genome of mouse." [OMA:P06804, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tnf" RELATED Gene-based [UniProtKB:P06804]
synonym: "Tnfa" RELATED Gene-based [UniProtKB:P06804]
synonym: "mTNF" EXACT PRO-short-label [PRO:DNx]
synonym: "Tnfsf2" RELATED Gene-based [UniProtKB:P06804]
synonym: "TNF-a (mouse)" EXACT [UniProtKB:P06804]
synonym: "TNF-alpha (mouse)" EXACT [UniProtKB:P06804]
synonym: "cachectin (mouse)" EXACT [UniProtKB:P06804]
synonym: "tumor necrosis factor ligand superfamily member 2 (mouse)" EXACT [UniProtKB:P06804]
xref: UniProtKB:P06804
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000134 ! tumor necrosis factor
relationship: has_gene_template MGI:104798 ! Tnf (mouse)

[Term]
id: PR:000000134
name: tumor necrosis factor
def: "A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA]
comment: Category=gene.
synonym: "TNF" EXACT PRO-short-label [PRO:DNx]
synonym: "TNFA" RELATED Gene-based []
synonym: "TNFa" EXACT []
synonym: "TNF-a" EXACT []
synonym: "TNFSF2" RELATED Gene-based []
synonym: "TNF-alpha" EXACT []
synonym: "cachectin" EXACT []
synonym: "tumor necrosis factor alpha" EXACT []
synonym: "tumor necrosis factor ligand superfamily member 2" EXACT []
xref: PIRSF:PIRSF500467
is_a: PR:000000033 ! tumor necrosis factor, TNF-like

[Term]
id: PR:000036505
name: tumor necrosis factor isoform 1 cleaved 1 (mouse)
def: "A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000034436" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mTNF/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06804-1, 80-235" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000604 ! tumor necrosis factor isoform 1 cleaved 1

[Term]
id: PR:000036506
name: tumor necrosis factor isoform 1 cleaved 2 (mouse)
def: "A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTNF/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06804-1, 70-235" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000605 ! tumor necrosis factor isoform 1 cleaved 2