[Term]
id: PR:P23443
name: ribosomal protein S6 kinase beta-1 (human)
def: "A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P23443]
comment: Category=organism-gene.
synonym: "STK14A" RELATED Gene-based [UniProtKB:P23443]
synonym: "RPS6KB1" RELATED Gene-based [UniProtKB:P23443]
synonym: "hRPS6KB1" EXACT PRO-short-label [PRO:DNx]
synonym: "S6K1 (human)" EXACT [UniProtKB:P23443]
synonym: "P70S6K1 (human)" EXACT [UniProtKB:P23443]
synonym: "p70 S6KA (human)" EXACT [UniProtKB:P23443]
synonym: "p70-S6K 1 (human)" EXACT [UniProtKB:P23443]
synonym: "S6K-beta-1 (human)" EXACT [UniProtKB:P23443]
synonym: "p70 S6K-alpha (human)" EXACT [UniProtKB:P23443]
synonym: "p70 S6 kinase alpha (human)" EXACT [UniProtKB:P23443]
synonym: "p70 ribosomal S6 kinase alpha (human)" EXACT [UniProtKB:P23443]
synonym: "ribosomal protein S6 kinase I (human)" EXACT [UniProtKB:P23443]
synonym: "serine/threonine-protein kinase 14A (human)" EXACT [UniProtKB:P23443]
synonym: "70 kDa ribosomal protein S6 kinase 1 (human)" EXACT [UniProtKB:P23443]
xref: Reactome:R-HSA-165716 "PR:P23443 located_in GO:0005829"
xref: DTO:03100257
xref: UniProtKB:P23443
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000123 ! ribosomal protein S6 kinase beta-1
relationship: has_gene_template HGNC:10436 ! RPS6KB1 (human)

[Term]
id: PR:Q8BSK8
name: ribosomal protein S6 kinase beta-1 (mouse)
def: "A ribosomal protein S6 kinase beta-1 that is encoded in the genome of mouse." [OMA:Q8BSK8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rps6kb1" RELATED Gene-based [UniProtKB:Q8BSK8]
synonym: "mRPS6KB1" EXACT PRO-short-label [PRO:DNx]
synonym: "S6K (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "S6K1 (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "P70S6K1 (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "p70 S6KA (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "p70-S6K 1 (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "S6K-beta-1 (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "p70 S6K-alpha (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "p70 S6 kinase alpha (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "p70 ribosomal S6 kinase alpha (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "ribosomal protein S6 kinase I (mouse)" EXACT [UniProtKB:Q8BSK8]
synonym: "70 kDa ribosomal protein S6 kinase 1 (mouse)" EXACT [UniProtKB:Q8BSK8]
xref: UniProtKB:Q8BSK8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000123 ! ribosomal protein S6 kinase beta-1
relationship: has_gene_template MGI:1270849 ! Rps6kb1 (mouse)

[Term]
id: PR:000000123
name: ribosomal protein S6 kinase beta-1
def: "A ribosomal protein S6 kinase beta that is a translation product of the human RPS6KB1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "S6K" EXACT []
synonym: "S6K1" EXACT []
synonym: "STK14A" RELATED Gene-based []
synonym: "P70S6K1" EXACT []
synonym: "RPS6KB1" EXACT PRO-short-label [PRO:DNx]
synonym: "p70 S6KA" EXACT []
synonym: "p70-S6K 1" EXACT []
synonym: "S6K-beta-1" EXACT []
synonym: "p70 S6K-alpha" EXACT []
synonym: "p70 S6 kinase alpha" EXACT []
synonym: "p70 ribosomal S6 kinase alpha" EXACT []
synonym: "ribosomal protein S6 kinase I" EXACT []
synonym: "serine/threonine-protein kinase 14A" EXACT []
synonym: "70 kDa ribosomal protein S6 kinase 1" EXACT []
xref: IUPHARobj:1525
is_a: PR:000000025 ! ribosomal protein S6 kinase beta

[Term]
id: PR:000000310
name: ribosomal protein S6 kinase beta-1 isoform 1
def: "A ribosomal protein S6 kinase beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "Alpha I" RELATED []
synonym: "RPS6KB1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000123 ! ribosomal protein S6 kinase beta-1

[Term]
id: PR:000000311
name: ribosomal protein S6 kinase beta-1 isoform 2
def: "A ribosomal protein S6 kinase beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "Alpha II" RELATED []
synonym: "RPS6KB1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000123 ! ribosomal protein S6 kinase beta-1

[Term]
id: PR:000000464
name: ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated form
def: "A ribosomal protein S6 kinase beta-1 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "RPS6KB1/iso:2/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000311 ! ribosomal protein S6 kinase beta-1 isoform 2

[Term]
id: PR:P67999
name: ribosomal protein S6 kinase beta-1 (rat)
def: "A ribosomal protein S6 kinase beta-1 that is encoded in the genome of rat." [OMA:P67999, PANTHER:PTHR24351:SF83, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rps6kb1" RELATED Gene-based [UniProtKB:P67999]
synonym: "rRPS6KB1" EXACT PRO-short-label [PRO:DNx]
synonym: "S6K1 (rat)" EXACT [UniProtKB:P67999]
synonym: "P70S6K1 (rat)" EXACT [UniProtKB:P67999]
synonym: "p70 S6KA (rat)" EXACT [UniProtKB:P67999]
synonym: "p70-S6K 1 (rat)" EXACT [UniProtKB:P67999]
synonym: "S6K-beta-1 (rat)" EXACT [UniProtKB:P67999]
synonym: "p70 S6K-alpha (rat)" EXACT [UniProtKB:P67999]
synonym: "p70 S6 kinase alpha (rat)" EXACT [UniProtKB:P67999]
synonym: "p70 ribosomal S6 kinase alpha (rat)" EXACT [UniProtKB:P67999]
synonym: "ribosomal protein S6 kinase I (rat)" EXACT [UniProtKB:P67999]
synonym: "70 kDa ribosomal protein S6 kinase 1 (rat)" EXACT [UniProtKB:P67999]
xref: UniProtKB:P67999
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000123 ! ribosomal protein S6 kinase beta-1
relationship: has_gene_template RGD:620683 ! Rps6kb1 (rat)

[Term]
id: PR:000000567
name: ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1
def: "A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated form in which the phosphorylation occurs within the AGC-kinase C-terminal domain. Example: UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047." [PMID:1922062]
comment: Category=modification. Note: AGC kinases are serine/threonine protein kinases. The phosphorylation sites serve as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive.
synonym: "RPS6KB1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000463 ! ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q8BSK8-2
name: ribosomal protein S6 kinase beta-1 isoform Alpha II (mouse)
def: "A ribosomal protein S6 kinase beta-1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mRPS6KB1/iso:Alpha II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BSK8-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000311 ! ribosomal protein S6 kinase beta-1 isoform 2

[Term]
id: PR:Q8BSK8-1
name: ribosomal protein S6 kinase beta-1 isoform Alpha I (mouse)
def: "A ribosomal protein S6 kinase beta-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mRPS6KB1/iso:Alpha I" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BSK8-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000310 ! ribosomal protein S6 kinase beta-1 isoform 1

[Term]
id: PR:000000568
name: ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1
def: "A ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated form in which the phosphorylation occurs within the AGC-kinase C-terminal domain. These sites serve as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive." [PMID:1922062]
comment: Category=modification. Note: AGC kinases are serine/threonine protein kinases.
synonym: "RPS6KB1/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000464 ! ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000036481
name: ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 (human)
def: "A ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 in human." [PMID:1922062, PRO:CNA]
comment: Category=organism-modification.
synonym: "hRPS6KB1/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000568 ! ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P23443-5
name: ribosomal protein S6 kinase beta-1 isoform h4 (human)
def: "A ribosomal protein S6 kinase beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-5." [PRO:DNx, UniProtKB:P23443]
comment: Category=organism-sequence.
synonym: "hRPS6KB1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23443-5
is_a: PR:P23443 ! ribosomal protein S6 kinase beta-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23443-1
name: ribosomal protein S6 kinase beta-1 isoform Alpha I (human)
def: "A ribosomal protein S6 kinase beta-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hRPS6KB1/iso:Alpha I" EXACT PRO-short-label [PRO:DNx]
synonym: "ribosomal protein S6 kinase beta-1 isoform p80-S6K 1 (human)" EXACT [UniProtKB:P23443]
xref: UniProtKB:P23443-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000310 ! ribosomal protein S6 kinase beta-1 isoform 1

[Term]
id: PR:P23443-2
name: ribosomal protein S6 kinase beta-1 isoform Alpha II (human)
def: "A ribosomal protein S6 kinase beta-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hRPS6KB1/iso:Alpha II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23443-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000311 ! ribosomal protein S6 kinase beta-1 isoform 2

[Term]
id: PR:P23443-3
name: ribosomal protein S6 kinase beta-1 isoform h2 (human)
def: "A ribosomal protein S6 kinase beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-3." [PRO:DNx, UniProtKB:P23443]
comment: Category=organism-sequence.
synonym: "hRPS6KB1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23443-3
is_a: PR:P23443 ! ribosomal protein S6 kinase beta-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23443-4
name: ribosomal protein S6 kinase beta-1 isoform h3 (human)
def: "A ribosomal protein S6 kinase beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-4." [PRO:DNx, UniProtKB:P23443]
comment: Category=organism-sequence.
synonym: "hRPS6KB1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23443-4
is_a: PR:P23443 ! ribosomal protein S6 kinase beta-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036480
name: ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 (human)
def: "A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 in human. UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047." [PMID:1922062, PRO:CNA]
comment: Category=organism-modification.
synonym: "hRPS6KB1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000567 ! ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P67999-1
name: ribosomal protein S6 kinase beta-1 isoform Alpha I (rat)
def: "A ribosomal protein S6 kinase beta-1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P67999-1." [PRO:DNx, UniProtKB:P67999]
comment: Category=organism-sequence.
synonym: "rRPS6KB1/iso:Alpha I" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P67999-1
is_a: PR:P67999 ! ribosomal protein S6 kinase beta-1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P67999-2
name: ribosomal protein S6 kinase beta-1 isoform Alpha II (rat)
def: "A ribosomal protein S6 kinase beta-1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P67999-2." [PRO:DNx, UniProtKB:P67999]
comment: Category=organism-sequence.
synonym: "rRPS6KB1/iso:Alpha II" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P67999-2
is_a: PR:P67999 ! ribosomal protein S6 kinase beta-1 (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000049135
name: ribosomal protein S6 kinase beta-1 phosphorylated 2 (human)
def: "A ribosomal protein S6 kinase beta-1 (human) that has been post-translationally modified to include phosphoserine at position 394, and phosphothreonine at position 412 of the amino acid sequence represented by UniProtKB:P23443. UniProtKB:P23443, Ser-394, MOD:00046|Thr-412, MOD:00047." [PRO:DAN, Reactome:R-HSA-165714]
comment: Category=organism-modification. Note: Numbering in some publications reflect that of isoform known at the time, which is now the shorter isoform (-2; with modifications at Ser-371 and Thr-394).
synonym: "hRPS6KB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P23443, Ser-394, MOD:00046|Thr-412, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "UniProtKB:P23443-1, Ser-394, MOD:00046|Thr-412, MOD:00047" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "UniProtKB:P23443-2, Ser-371, MOD:00046|Thr-389, MOD:00047" NARROW PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-165714 "PR:000049135 located_in GO:0005829"
is_a: PR:P23443 ! ribosomal protein S6 kinase beta-1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000463
name: ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated form
def: "A ribosomal protein S6 kinase beta-1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "RPS6KB1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000310 ! ribosomal protein S6 kinase beta-1 isoform 1