[Term]
id: PR:000000105
name: nodal protein
def: "A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]
comment: Category=gene.
synonym: "NODAL" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF037400
is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine

[Term]
id: PR:000000558
name: nodal protein isoform 1, signal peptide removed form
def: "A nodal protein isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:CNA]
comment: Category=modification.
synonym: "NODAL/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "nodal protein isoform 1 cleaved 1" EXACT []
intersection_of: PR:000000291 ! nodal protein isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:Q96S42-1
name: nodal homolog isoform 1 (human)
def: "A nodal protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNODAL/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96S42-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000291 ! nodal protein isoform 1

[Term]
id: PR:P43021
name: nodal (mouse)
def: "A nodal protein that is encoded in the genome of mouse." [OMA:P43021, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nodal" RELATED Gene-based [UniProtKB:P43021]
synonym: "mNODAL" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43021
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000105 ! nodal protein
relationship: has_gene_template MGI:97359 ! Nodal (mouse)

[Term]
id: PR:000025433
name: nodal protein proteolytic cleavage product
def: "A nodal protein that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "NODAL/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000105 ! nodal protein

[Term]
id: PR:Q96S42
name: nodal homolog (human)
def: "A nodal protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96S42]
comment: Category=organism-gene.
synonym: "NODAL" RELATED Gene-based [UniProtKB:Q96S42]
synonym: "hNODAL" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96S42
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000105 ! nodal protein
relationship: has_gene_template HGNC:7865 ! NODAL (human)

[Term]
id: PR:000036469
name: nodal protein isoform 1, signal peptide removed form (mouse)
def: "A nodal protein isoform 1, signal peptide removed form in mouse. UniProtKB:P43021-1, ?-354." [PMID:12654299, PMID:15004567, PMID:15649361, PRO:CNA]
comment: Category=organism-modification.
synonym: "mNODAL/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P43021-1, ?-354" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000558 ! nodal protein isoform 1, signal peptide removed form

[Term]
id: PR:000048620
name: nodal homolog, signal peptide removed form (human)
def: "A nodal homolog (human) that has had the signal peptide removed. UniProtKB:Q96S42, 27-347." [PRO:DNx, Reactome:R-HSA-1181114]
comment: Category=organism-modification.
synonym: "hNODAL/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96S42, 27-347" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1181114 "PR:000048620 located_in GO:0005576"
intersection_of: PR:Q96S42 ! nodal homolog (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P43021-1
name: nodal isoform 1 (mouse)
def: "A nodal protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mNODAL/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P43021-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000291 ! nodal protein isoform 1

[Term]
id: PR:000000291
name: nodal protein isoform 1
def: "A nodal protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96S42-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "precursor" RELATED []
synonym: "NODAL/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000105 ! nodal protein

[Term]
id: PR:000000292
name: nodal protein sequence variant R183Q (human)
def: "A nodal homolog (human) that has a Gln residue at the position equivalent to Arg-183 of the amino acid sequence represented by UniProtKB:Q96S42. UniProtKB:Q96S42, Arg-183, CHEBI:30011." [PMID:9354794, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNODAL/var:R183Q" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96S42, Arg-183, CHEBI:30011" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "nodal protein sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_015111
is_a: PR:Q96S42 ! nodal homolog (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens