[Term]
id: PR:000000104
name: mitogen-activated protein kinase 3
def: "A mitogen-activated protein kinase that is a translation product of the human MAPK3 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ERK1" RELATED Gene-based []
synonym: "ERT2" EXACT []
synonym: "MNK1" EXACT []
synonym: "ERK-1" EXACT []
synonym: "MAPK3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKM3" RELATED Gene-based []
synonym: "MAPK 1" RELATED []
synonym: "MAPK 3" EXACT []
synonym: "p44-ERK1" EXACT []
synonym: "p44-MAPK" EXACT []
synonym: "MAP kinase 1" RELATED []
synonym: "MAP kinase 3" EXACT []
synonym: "MAP kinase isoform p44" EXACT []
synonym: "insulin-stimulated MAP2 kinase" EXACT []
synonym: "mitogen-activated protein kinase 1" RELATED []
synonym: "extracellular signal-regulated kinase 1" EXACT []
synonym: "microtubule-associated protein 2 kinase" EXACT []
xref: IUPHARobj:1494
is_a: PR:000000019 ! mitogen-activated protein kinase

[Term]
id: PR:P27361
name: mitogen-activated protein kinase 3 (human)
def: "A mitogen-activated protein kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P27361]
comment: Category=organism-gene.
synonym: "ERK1" RELATED Gene-based [UniProtKB:P27361]
synonym: "MAPK3" RELATED Gene-based [UniProtKB:P27361]
synonym: "PRKM3" RELATED Gene-based [UniProtKB:P27361]
synonym: "hMAPK3" EXACT PRO-short-label [PRO:DNx]
synonym: "ERT2 (human)" EXACT [UniProtKB:P27361]
synonym: "ERK-1 (human)" EXACT [UniProtKB:P27361]
synonym: "MAPK 3 (human)" EXACT [UniProtKB:P27361]
synonym: "p44-ERK1 (human)" EXACT [UniProtKB:P27361]
synonym: "p44-MAPK (human)" EXACT [UniProtKB:P27361]
synonym: "MAP kinase 3 (human)" EXACT [UniProtKB:P27361]
synonym: "MAP kinase isoform p44 (human)" EXACT [UniProtKB:P27361]
synonym: "insulin-stimulated MAP2 kinase (human)" EXACT [UniProtKB:P27361]
synonym: "extracellular signal-regulated kinase 1 (human)" EXACT [UniProtKB:P27361]
synonym: "microtubule-associated protein 2 kinase (human)" EXACT [UniProtKB:P27361]
xref: DTO:03100316
xref: UniProtKB:P27361
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000104 ! mitogen-activated protein kinase 3
relationship: has_gene_template HGNC:6877 ! MAPK3 (human)

[Term]
id: PR:P27361-3
name: mitogen-activated protein kinase 3 isoform h3 (human)
def: "A mitogen-activated protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-3." [PRO:DNx, UniProtKB:P27361]
comment: Category=organism-sequence.
synonym: "hMAPK3/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "mitogen-activated protein kinase 3 isoform ERK1b (human)" EXACT [UniProtKB:P27361]
xref: UniProtKB:P27361-3
is_a: PR:P27361 ! mitogen-activated protein kinase 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048321
name: mitogen-activated protein kinase 3, initiator methionine removed form (human)
def: "A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed. UniProtKB:P27361, 2-379." [PRO:DNx, Reactome:R-HSA-59284, Reactome:R-HSA-73724]
comment: Category=organism-modification.
synonym: "PRO_0000186251" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAPK3/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27361, 2-379" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-59284 "PR:000048321 located_in GO:0005829"
xref: Reactome:R-HSA-9636295 "PR:000048321 located_in GO:0005788"
xref: Reactome:R-HSA-73724 "PR:000048321 located_in GO:0005654"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P27361 ! mitogen-activated protein kinase 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048322
name: mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 202, and phosphotyrosine at position 204 of the amino acid sequence represented by UniProtKB:P27361. UniProtKB:P27361, 2-379, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-109842, Reactome:R-HSA-112359]
comment: Category=organism-modification.
synonym: "hMAPK3/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000186251, Thr-202, MOD:00047|Tyr-204, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P27361, 2-379, Thr-202, MOD:00047|Tyr-204, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-109842 "PR:000048322 located_in GO:0005829"
xref: Reactome:R-HSA-112359 "PR:000048322 located_in GO:0005654"
is_a: PR:P27361 ! mitogen-activated protein kinase 3 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000026189
name: mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]
comment: Category=organism-modification.
synonym: "activated ERK1" EXACT []
synonym: "activated MAPK3" EXACT []
synonym: "hMAPK3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000557 ! mitogen-activated protein kinase 3 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P27361-2
name: mitogen-activated protein kinase 3 isoform h2 (human)
def: "A mitogen-activated protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-2." [PRO:DNx, UniProtKB:P27361]
comment: Category=organism-sequence.
synonym: "hMAPK3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27361-2
is_a: PR:P27361 ! mitogen-activated protein kinase 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27361-1
name: mitogen-activated protein kinase 3 isoform 1 (human)
def: "A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hMAPK3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27361-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000290 ! mitogen-activated protein kinase 3 isoform 1