[Term]
id: PR:000000538
name: c-myc protein isoform 1 phosphorylated 2
def: "A c-myc protein isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser and Thr residues within the L[LY]PTLTPPLS sequence of the Myc box I within the amino-terminal regulatory domain, by ERK and GSK3, respectively. Example: UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:14563837, PMID:8386367]
comment: Category=modification. Note: This form is not stable and is degraded through the proteosome pathway.
synonym: "MYC/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000422 ! c-myc protein isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000539
name: c-myc protein isoform 1 phosphorylated 3
def: "A c-myc protein isoform 1 phosphorylated form in which the phosphorylation occurs at Ser residues of the Myc box I in the amino-terminal regulatory domain by activation of ROCK proteins through Ras signaling pathway. Example: UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046." [PMID:12676581, UniProtKB:P01106]
comment: Category=modification.
synonym: "MYC/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000422 ! c-myc protein isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P01106-2
name: c-myc protein isoform 2 (human)
def: "A c-myc protein isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMYC/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01106-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000229 ! c-myc protein isoform 2

[Term]
id: PR:000002503
name: c-myc protein isoform 1 unmodified form
def: "A c-myc protein isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "MYC/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000228 ! c-myc protein isoform 1
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000000535
name: c-myc protein isoform 1 acetylated 1
def: "A c-myc protein isoform 1 acetylated form that has been acetylated at Lys residues by histone acetyltransferase p300. Example: UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394." [PMID:16126174, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "MYC/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000420 ! c-myc protein isoform 1 acetylated form
relationship: has_part MOD:00394 ! acetylated residue

[Term]
id: PR:000000536
name: c-myc protein isoform 1 O-glycosylated 1
def: "A c-myc protein isoform 1 glycosylated form that has been O-glycosylated at the Thr residue within the L[LY]PTLTPPLS sequence of the Myc box I within the amino-terminal regulatory domain. Example: UniProtKB:P01106-1, Thr-58, MOD:00806." [PMID:11904304, PMID:7642555]
comment: Category=modification.
synonym: "MYC/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000421 ! c-myc protein isoform 1 glycosylated form
relationship: has_part MOD:00806 ! O-(N-acetylamino)glucosyl-L-threonine

[Term]
id: PR:000000537
name: c-myc protein isoform 1 phosphorylated 1
def: "A c-myc protein isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue within the L[LY]PTLTPPLS sequence of the Myc box I within the amino-terminal regulatory domain by ERK through activation of Raf signaling pathway. Example: UniProtKB:P01106-1, Ser-62, MOD:00046." [PMID:11018017]
comment: Category=modification.
synonym: "MYC/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000422 ! c-myc protein isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P01106-1
name: c-myc protein isoform 1 (human)
def: "A c-myc protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMYC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01106-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000228 ! c-myc protein isoform 1

[Term]
id: PR:000026038
name: c-myc protein isoform 1 unmodified form (human)
def: "A c-myc protein isoform 1 unmodified form in human." [PMID:15003254, PRO:CNA]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002503 ! c-myc protein isoform 1 unmodified form

[Term]
id: PR:000026033
name: c-myc protein isoform 1 acetylated 1 (human)
def: "A c-myc protein isoform 1 acetylated 1 in human. UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394." [PMID:16126174]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000535 ! c-myc protein isoform 1 acetylated 1
relationship: has_part MOD:00394 ! acetylated residue

[Term]
id: PR:P01109
name: Myc proto-oncogene protein (chicken)
def: "A c-myc protein that is encoded in the genome of chicken." [OMA:P01109, PRO:DNx]
comment: Category=organism-gene.
synonym: "MYC" RELATED Gene-based [UniProtKB:P01109]
synonym: "chick-MYC" EXACT PRO-short-label [PRO:DNx]
synonym: "c-Myc (chicken)" EXACT [UniProtKB:P01109]
xref: UniProtKB:P01109
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000084 ! c-myc protein
relationship: has_gene_template NCBIGene:420332 ! MYC (chicken)

[Term]
id: PR:P01108
name: Myc proto-oncogene protein (mouse)
def: "A c-myc protein that is encoded in the genome of mouse." [OMA:P01108, PRO:DNx]
comment: Category=organism-gene.
synonym: "Myc" RELATED Gene-based [UniProtKB:P01108]
synonym: "mMYC" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene c-Myc (mouse)" EXACT [UniProtKB:P01108]
synonym: "transcription factor p64 (mouse)" EXACT [UniProtKB:P01108]
xref: UniProtKB:P01108
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000084 ! c-myc protein
relationship: has_gene_template MGI:97250 ! Myc (mouse)

[Term]
id: PR:000026055
name: c-myc protein isoform 1 phosphorylated 3 (human)
def: "A c-myc protein isoform 1 phosphorylated 3 in human. UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046." [PMID:12676581]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000539 ! c-myc protein isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026054
name: c-myc protein isoform 1 phosphorylated 2 (human)
def: "A c-myc protein isoform 1 phosphorylated 2 in human. UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:7623799]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000538 ! c-myc protein isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000026053
name: c-myc protein isoform 1 phosphorylated 2 (mouse)
def: "A c-myc protein isoform 1 phosphorylated 2 in mouse. UniProtKB:P01108-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:14563837, PMID:15503302]
comment: Category=organism-modification.
synonym: "mMYC/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01108-1, Thr-58, MOD:00047|Ser-62, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000538 ! c-myc protein isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000026052
name: c-myc protein isoform 1 phosphorylated 1 (mouse)
def: "A c-myc protein isoform 1 phosphorylated 1 in mouse. UniProtKB:P01108-1, Ser-62, MOD:00046." [PMID:15048125]
comment: Category=organism-modification.
synonym: "mMYC/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01108-1, Ser-62, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000537 ! c-myc protein isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026051
name: c-myc protein isoform 1 O-glycosylated 1 (human)
def: "A c-myc protein isoform 1 O-glycosylated 1 in human. UniProtKB:P01106-1, Thr-58, MOD:00806." [PMID:11904304, PMID:7642555]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106-1, Thr-58, MOD:00806" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000536 ! c-myc protein isoform 1 O-glycosylated 1
relationship: has_part MOD:00806 ! O-(N-acetylamino)glucosyl-L-threonine

[Term]
id: PR:000000084
name: c-myc protein
def: "A Myc protein that is a translation product of the human MYC gene or a 1:1 ortholog thereof. The gene has 3 exons, with exon 1 lacking ATG codons." [PRO:CNA]
comment: Category=gene.
synonym: "MYC" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHE39" RELATED Gene-based []
synonym: "bHLHe39" EXACT []
synonym: "proto-oncogene c-Myc" EXACT []
synonym: "transcription factor p64" EXACT []
synonym: "class E basic helix-loop-helix protein 39" EXACT []
is_a: PR:000000020 ! Myc protein

[Term]
id: PR:P01106
name: Myc proto-oncogene protein (human)
def: "A c-myc protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01106]
comment: Category=organism-gene.
synonym: "MYC" RELATED Gene-based [UniProtKB:P01106]
synonym: "hMYC" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHE39" RELATED Gene-based [UniProtKB:P01106]
synonym: "proto-oncogene c-Myc (human)" EXACT [UniProtKB:P01106]
synonym: "transcription factor p64 (human)" EXACT [UniProtKB:P01106]
synonym: "class E basic helix-loop-helix protein 39 (human)" EXACT [UniProtKB:P01106]
xref: Reactome:R-HSA-188379 "PR:P01106 located_in GO:0005654"
xref: Reactome:R-HSA-4411332 "PR:P01106 located_in GO:0005829"
xref: UniProtKB:P01106
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000084 ! c-myc protein
relationship: has_gene_template HGNC:7553 ! MYC (human)

[Term]
id: PR:000000422
name: c-myc protein isoform 1 phosphorylated form
def: "A c-myc protein isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "MYC/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000228 ! c-myc protein isoform 1

[Term]
id: PR:000000420
name: c-myc protein isoform 1 acetylated form
def: "A c-myc protein isoform 1 that includes at least one acetylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "MYC/iso:1/AcRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00394 ! acetylated residue
intersection_of: PR:000000228 ! c-myc protein isoform 1

[Term]
id: PR:000000421
name: c-myc protein isoform 1 glycosylated form
def: "A c-myc protein isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "MYC/iso:1/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00693 ! glycosylated residue
intersection_of: PR:000000228 ! c-myc protein isoform 1

[Term]
id: PR:000048491
name: Myc proto-oncogene protein ubiquitinated form (human)
def: "A Myc proto-oncogene protein (human) that includes at least one ubiquitinated lysine. UniProtKB:P01106, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783169]
comment: Category=organism-modification.
synonym: "hMYC/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6783169 "PR:000048491 located_in GO:0005654"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P01106 ! Myc proto-oncogene protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01108-1
name: c-myc protein isoform 1 (mouse)
def: "A c-myc protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mMYC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01108-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000228 ! c-myc protein isoform 1

[Term]
id: PR:B2RSN1
name: c-myc protein isoform 2 (mouse)
def: "A c-myc protein isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mMYC/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:B2RSN1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000229 ! c-myc protein isoform 2

[Term]
id: PR:000036448
name: c-myc protein isoform 1 phosphorylated 1 (human)
def: "A c-myc protein isoform 1 phosphorylated 1 in human. UniProtKB:P01106-1, Ser-62, MOD:00046." [PMID:19131971, PRO:CNA]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106-1, Ser-62, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000537 ! c-myc protein isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P52160
name: transcriptional regulator Myc-A (zebrafish)
def: "A c-myc protein that is encoded in the genome of zebrafish." [OMA:P52160, PRO:DNx]
comment: Category=organism-gene.
synonym: "myc" RELATED Gene-based [UniProtKB:P52160]
synonym: "cmyc" RELATED Gene-based [UniProtKB:P52160]
synonym: "myca" RELATED Gene-based [UniProtKB:P52160]
synonym: "z-MYC" EXACT PRO-short-label [PRO:DNx]
synonym: "zc-Myc (zebrafish)" EXACT [UniProtKB:P52160]
synonym: "c-Myc-A (zebrafish)" EXACT [UniProtKB:P52160]
xref: UniProtKB:P52160
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000000084 ! c-myc protein
relationship: has_gene_template ZFIN:ZDB-GENE-990415-162 ! myca (zebrafish)

[Term]
id: PR:000000228
name: c-myc protein isoform 1
def: "A c-myc protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01106-1 or a 1:1 ortholog thereof." [PMID:3277717, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "MYC/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000084 ! c-myc protein

[Term]
id: PR:000000229
name: c-myc protein isoform 2
def: "A c-myc protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01106-2 or a 1:1 ortholog thereof." [PMID:3277717, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "p67" BROAD [PRO:DNx]
synonym: "p68" BROAD [PRO:DNx]
synonym: "MYC/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000084 ! c-myc protein

[Term]
id: PR:P09416
name: Myc proto-oncogene protein (rat)
def: "A c-myc protein that is encoded in the genome of rat." [PANTHER:PTHR11514:SF2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Myc" RELATED Gene-based [UniProtKB:P09416]
synonym: "rMYC" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene c-Myc (rat)" EXACT [UniProtKB:P09416]
synonym: "transcription factor p64 (rat)" EXACT [UniProtKB:P09416]
xref: UniProtKB:P09416
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000084 ! c-myc protein
relationship: has_gene_template RGD:3130 ! Myc (rat)

[Term]
id: PR:000026040
name: c-myc protein isoform 1 phosphorylated 4
def: "A c-myc protein isoform 1 phosphorylated form that is phosphorylated on a residue equivalent to Thr-58 of the amino acid sequence represented by P01106-1. It is the product of dephosphorylation of the doubly phosphorylated form (PR:000000538) by PP2A phosphatase. The phosphorylated Thr residue is important for protein stability. Example: UniProtKB:P01106-1, Thr-58, MOD:00047." [PMID:19131971, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "MYC/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000422 ! c-myc protein isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000026041
name: c-myc protein isoform 1 phosphorylated 4 (human)
def: "A c-myc protein isoform 1 phosphorylated 4 in human. UniProtKB:P01106-1, Thr-58, MOD:00047." [PMID:19131971]
comment: Category=organism-modification.
synonym: "hMYC/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01106-1, Thr-58, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026040 ! c-myc protein isoform 1 phosphorylated 4
relationship: has_part MOD:00047 ! O-phospho-L-threonine